A5101568298- Chronic Kidney Disease and Diabetes
- Lipid metabolism and disorders
- Gout, Hyperuricemia, Uric Acid
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Dysphagia Assessment and Management
- Liver Disease Diagnosis and Treatment
- Vitamin D Research Studies
- Renal Diseases and Glomerulopathies
- Recommender Systems and Techniques
- Dialysis and Renal Disease Management
- Advanced Graph Neural Networks
- Direction-of-Arrival Estimation Techniques
- Neonatal Health and Biochemistry
- Caveolin-1 and cellular processes
- Apelin-related biomedical research
- Speech and Audio Processing
- Alcohol Consumption and Health Effects
- Advanced Glycation End Products research
- Diabetes and associated disorders
- Wireless Signal Modulation Classification
- Topic Modeling
- Retinal Imaging and Analysis
- Blind Source Separation Techniques
- EEG and Brain-Computer Interfaces
- Diabetes Treatment and Management
Panyu District Central Hospital
2019-2024
Tongji University
2022-2024
Fuzhou University
2023-2024
Fudan University
2020-2024
Shanghai Tenth People's Hospital
2024
Beijing University of Technology
2024
Chongqing Normal University
2024
Systems Engineering Society of China
2023
Shanghai Jiao Tong University
2012-2021
Minhang District Central Hospital
2020-2021
The overproduction of mitochondrial reactive oxygen species (ROS) plays a key role in the pathogenesis diabetic nephropathy (DN). However, underlying molecular mechanism remains unclear. Our aim was to investigate PGC-1α DN. Rat glomerular mesangial cells (RMCs) were incubated normal or high glucose medium with without PGC-1α-overexpressing plasmid (pcDNA3-PGC-1α) for 48 h. In rats, decreased expression associated increased ROS generation renal cortex, proteinuria, hypertrophy, and higher...
In this study, circulating serum betatrophin levels were quantitated and their relationships with insulin resistance (IR) other metabolic parameters in Chinese subjects varying degrees of obesity glucose tolerance examined. Serum determined using ELISA 60 normal (NGT: 17 lean, 23 overweight, 20 obese subjects) 56 type 2 diabetes mellitus (T2DM: 14 19 subjects). The associations adiposity, glucose, lipid profile, hepatic enzyme studied. concentrations significantly higher overweight both the...
Background Upper limb intelligence robots are widely used to improve the upper function of patients with stroke, but treatment mechanism is still not clear. In this study, functional near-infrared spectroscopy (fNIRS) was evaluate concentration changes oxygenated hemoglobin (oxy-Hb) and deoxyhemoglobin (deoxy-Hb) in different brain regions connectivity (FC) cerebral cortex stroke. Method Twenty post-stroke dysfunction were included study. They all received three types shoulder joint...
Low vitamin D levels can be associated with albuminuria, and analogs are effective anti-proteinuric agents. The aim of this study was to investigate differences in between those micro- macroalbuminuria, determine whether low dose cholecalciferol increases ameliorates albuminuria.Two studies were performed which 25-OH D(3) (25(OH)D(3)) concentrations determined by electrochemiluminescence immunoassay: 1) a cross-sectional patients type 2 diabetes mellitus (T2DM) (n = 481) healthy controls...
Objective To test the hypothesis that a microalbuminuria (MA) threshold can help predict risk for development of diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM)_ patients. Design We conducted cross-sectional study 4739 subjects with T2DM and prospective 297 China respectively. Methods Clinical laboratory data were collected biologic factors associated any DR analysed. Results In study, we found MA was an independent factor development; further, when patients divided into...
Our objective was to ascertain the most recent prevalence and trends of hyperuricemia among adolescents, stratified by sex race/ethnicity subgroups, as well investigate potential risk factors associated with in US adolescents.
Abstract A growing body of evidence suggests that NAFLD is associated with an increased risk incident CVD events both in patients without diabetes and those type 2 (T2DM). However, no published data are available regarding the association between C-IMT T1DM. total 722 (371 men) T1DM were included this cross-sectional study. The main outcome measures detection NAFLD, classical factors. mean age subjects was 46.2 years, 51.1% male. prevalence 15.9%. had a markedly greater (0.81 ± 0.25 vs. 0.69...
To construct a simple screening tool for predicting diabetic kidney disease in Chinese patients with type 2 diabetes.In the development cohort, clinical and procedural characteristics of 4,795 were considered as candidate univariate predictors disease. The β-coefficients derived from multiple logistic regression model presence DKD used to calculate risk score. performance score was validated cross-sectional prospective cohort population.The included sex, body mass index, systolic blood...
Stroke is the most common cause of human death and functional disability, resulting in more than 5 million deaths worldwide each year. Bone marrow mesenchymal stem cells (BMSCs) are a kind cell that able to self-renew differentiate into many types tissues. Therefore, BMSCs have potential replace damaged neurons promote reconstruction nerve conduction pathways connective tissue. However, it remains unknown whether transplanted angiogenesis or improve tissue microenvironment directly...
Recent studies highlight a negative association between total bilirubin concentrations and albuminuria in patients with type 2 diabetes mellitus. Our study evaluated the relationship prevalence of diabetic nephropathy (DN) Chinese 1 mellitus (T1DM). A 258 T1DM were recruited compared or without nephropathy. Multiple stepwise regression analysis was used to examine 24 h urinary microalbumin. Binary logistic performed assess independent risk factors for Participants divided into four groups...
Analyzing medical records takes a large amount of time and resources for workers. Therefore, the advancement report generation technology is critical saving doctors' while producing reports. Some diseases frequently exhibit co-occurrence interactions in context picture categorization creation, which necessitate hu-man-designed added representation. To further capture this latent information, we propose creating disease matrix from existing dataset training graph neural network on it. We use...
Background: Inositol-requiring enzyme 1 (IRE1) plays a critical role in attenuating endoplasmic reticulum (ER) stress associated with renal injury which may also be factor diabetic nephropathy (DN). Alcohol dehydrogenase type I (ADH1) activity is prominent the kidney, ADH1 reported to exert protective effects against ER that are not caused by alcohol consumption. However, of IRE1 DN and correlation between remain unclear.Methods: IRE1α floxed mice (Ire1f/f) C57BL/6J background were...
Background: Diabetic nephropathy is one of the major microvascular complications diabetes.We investigated association between urinary Smad3 (usmad3) levels, glomerular hyperfiltration, and development in patients with type 2 diabetes mellitus (T2DM).Methods: The usmad3 level was determined by enzyme-linked immunosorbent assay 245 well-characterised T2DM 82 healthy control subjects.The associations glucose lipid profiles, renal function were evaluated.Results: significantly higher than...
This study compared the differences in degree of brain activation, and swallowing function scales patients with post-stroke dysphagia after treatment. We explored mechanism cortical remodeling improvement effect electroacupuncture on provided a theoretical basis for clinical application electroacupuncture.Fifty were randomized to control or group. The group underwent conventional rehabilitation 30 min each time 12 sessions. In group, was performed based Cortical activation tests assessments...
Abstract Urate in the fingernails of gout patients and healthy volunteers was successfully detected by high-performance liquid chromatography (HPLC) with ultraviolet (UV) our previous research. This study aimed to further investigate whether nail urate could be a proxy for burden monosodium (MSU) crystals deposits gout. To this end, we conducted two parts. Firstly, HPLC–UV evaluated concentrations control subjects As expected, found that levels were significantly higher than controls, level...