A5100350589- Traditional Chinese Medicine Studies
- Nutrition and Health in Aging
- Liver Disease Diagnosis and Treatment
- Pain Mechanisms and Treatments
- Attention Deficit Hyperactivity Disorder
- Respiratory and Cough-Related Research
- Liver Disease and Transplantation
- Voice and Speech Disorders
- Dysphagia Assessment and Management
- Cholesterol and Lipid Metabolism
- Healthcare and Venom Research
- Peripheral Neuropathies and Disorders
- Neuroscience and Neuropharmacology Research
- Pancreatic function and diabetes
- Acupuncture Treatment Research Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Aldose Reductase and Taurine
- Neuropeptides and Animal Physiology
- GABA and Rice Research
- Graph theory and applications
- Menstrual Health and Disorders
- Atherosclerosis and Cardiovascular Diseases
- Multiple Sclerosis Research Studies
- Dietetics, Nutrition, and Education
- Thyroid Cancer Diagnosis and Treatment
Seoul National University
2022-2024
Pusan National University
2018-2023
Seoul National University Bundang Hospital
2006-2022
Yonsei University
2022
Yeungnam University Medical Center
2015-2016
University of Toronto
2014
Ewha Womans University
2014
Chungnam National University
2014
Institute of Clinical Research
2013
Kyungpook National University
2010
There is increasing recognition of the important role that B cells play in pathogenesis multiple sclerosis (MS). Recently it was reported cell chemokine CXCL13 elevated MS serum and cerebrospinal fluid. Here we study whether levels are associated with active MS. We measured by enzyme-linked immunosorbent assay 74 patients relapsing randomized to interferon beta 1b or glatiramer acetate examined monthly 3 T brain MRI scans optimized for detection gadolinium-enhancement up 2 years. The median...
The role of omega-3 polyunsaturated fatty acids (ω3-PUFAs) in cancer prevention has been demonstrated; however, the exact molecular mechanisms underlying anticancer activity ω3-PUFAs are not fully understood. Here, we investigated relationship between action a specific ω3-PUFA docosahexaenoic acid (DHA), and conventional mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase (ERK), c-JUN N-terminal (JNK) p38 whose dysregulation implicated human cancers.MTT...
The flavonoid naringin was investigated for its differential effects on hepatic cholesterol regulation when supplemented 3 weeks and 6 weeks. Sprague-Dawley rats were fed a high-fat high-cholesterol diet with or without 0.02% supplement Supplementation resulted in significant decrease the plasma triglyceride concentrations 6-week trial. Although high-density lipoprotein (HDL)-cholesterol not altered either trial, HDL-cholesterol/total ratio (in percent) significantly higher, atherogenic...
Individuals with attention-deficit/hyperactivity disorder (ADHD) are reported to manifest visual problems (including ophthalmological and color perception, particularly for blue-yellow stimuli), but findings inconsistent. Accordingly, this study investigated function perception in adolescents ADHD using Visual Evoked Potentials (cVEP), which provides an objective measure of perception.Thirty-one (aged 13-18), 16 a confirmed diagnosis ADHD, 15 healthy peers, matched age, gender, IQ...
Objective Lumbar disc herniation can induce sciatica by mechanical compression and/or chemical irritation. The aim of this study was to compare the effects GCSB-5 (Shinbaro®) and NSAIDs on pain-related behavior expressions microglia, astrocytes, CGRP, TRPV1, IL-6, CX3CL1 in a rat model lumbar herniation. Methods 112 male Sprague-Dawley rats underwent implantation nucleus pulposus dorsal root ganglion (DRG). Rats were divided into five groups as follows; saline group (the vehicle control...
Herniation in a Rat ModelLumbar disc herniation is commonly encountered clinical practice and can induce sciatica due to mechanical and/or chemical irritation the release of proinflammatory cytokines.However, symptoms are not confined affected spinal cord segment.The purpose this study was determine whether multisegmental molecular changes exist between adjacent lumbar segments using rat model herniation.Twenty-nine male Sprague-Dawley rats were randomly assigned either sham-operated group...
Although the healthcare policy was implemented to incentivize multidisciplinary services of hospital-based nutrition support team (NST) in South Korea, timely completion has been challenging hospitals. We enhanced NST information technology (NST−HIT) bridge gap between implementation and seamless execution hospital system. A 48 month pre-test−post-test study performed, including a 12 pre-intervention period, six intervention 30 post-intervention period. The NST−HIT provided sufficient...
The present study was performed to investigate the characteristics of breath groups while reading paragraph in normal adults and adult patients with voice disorders. 10 females(avr. 20.6 yrs.), young disorder 33.5 yrs., P1 group), old 56.3 P2 group) read a 210 syllables. By using 'Running Speech' program Phonatory Aerodynamic System(PAS), total duration, numbers groups, duration per group, syllables group were measured, their correlations aerodynamic measurement results analyzed. As result,...
Transmembrane 4 L six family member 5 (TM4SF5) engages in non-alcoholic steatohepatitis (NASH), although its mechanistic roles are unclear. Genetically engineered Tm4sf5 mice fed ad libitum normal chow or high-fat diet for either an entire day a daytime-feeding (DF) pattern were analyzed metabolic parameters. Compared to wild-type and Tm4sf5-/- knockout mice, hepatocyte-specific TM4SF5-overexpressing Alb-TGTm4sf5-Flag (TG) showed abnormal food-intake behavior during the mouse-inactive...
Fos, a protein product of immediate early gene c-fos, has been used as marker for activation nociceptive neurons in central nervous system including spinal trigeminal nucleus (Vsp). By noxious stimulation applied to orofacial area, the expression Fos occurred Vsp pars oralis (Vo), subnucleus receiving inputs from primary afferents that predominantly innervate intraoral receptive fields. The present study demonstrates vitro group I metabotropic glutamate receptors (mGluRs; mGluR1 and 5) by...
Abstract Background: Breast angiosarcoma represents around 20% of all angiosarcomas, and often spread to lung, liver, bones. Driver mutations angiosarcoma, specifically PTPRB, PLCG1, are well-known as reported previously. Notably, contralateral breast is another metastatic site the where an unusual location for other soft tissue sarcomas. However, it remains uncertain whether disease originates from primary tumor or emerges independently. Here, we present a 75-year-old woman with bilateral...
In 1972, Cvetković proved that if G is an n-vertex simple graph with the chromatic number k, then its spectral radius at most of balanced complete k-partite graph. this paper, we analyze characteristic polynomial a digraph D to prove tight upper bound for in terms vertices and D; also characterize when equality holds. This provides proof result by Lin Shu [6].
Objective The aim of this study was to find a correlation between the Nepean Dyspepsia Index (NDI) and electrogastrography (EGG) in clinical practice students. Methods In total, 28 students were enrolled. NDI EGG measured all classified as abnormal when score 11 or more. EGG, standard 1 if preprandial postprandial percentage normal gastric slow waves Ch3 less than 70% power ratio 1. Standard 2 met decreased after meals. Results had no statistically meaningful used, but used. Conclusions...
Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease characterized by multiorgan involvement with diverse clinical presentations. Central nervous system in neuropsychiatric syndromes of SLE (NPSLE), such as cerebrovascular and myelopathy, a major cause morbidity mortality patients. The concomitant occurrence disease, peripheral neuropathy patient has not yet been reported. We report on 41-year-old woman who showed motor sensory impairment urinary retention was...
Enteral nutrition (EN) supply within 48 hours after intensive care unit (ICU) admission improves clinical outcomes. The "new ICU evaluation & development of nutritional support protocol (NICE-NST)" was introduced in an tertiary academic hospital. This study showed that early EN through protocolized would more to improve outcomes.This screened 170 patients and 62 were finally enrolled; who supplied without the classified as control group (n=40), while those according test (n=22).In group,...
An adult beagle dog was presented with a cervical mass detected by palpation and computed tomography.Fine needle aspirates revealed numerous epithelial cells plasmacytoid appearance frequent naked nuclei.Histologically, the consists of multiple packets neoplastic extensive areas necrosis fibrosis.Neoplastic were also found in submandibular lymph nodes.Immunohistochemistry showed that positive for calcitonin negative thyroglobulin.Based on these findings, diagnosed as thyroid C-cell...