A5016772255- Pancreatic function and diabetes
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- T-cell and B-cell Immunology
- Cardiac Imaging and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Regulation of Appetite and Obesity
- Helicobacter pylori-related gastroenterology studies
- Tea Polyphenols and Effects
- Chemotherapy-induced organ toxicity mitigation
- Cardiovascular Function and Risk Factors
- Biochemical Analysis and Sensing Techniques
- Diabetes Management and Research
- Endoplasmic Reticulum Stress and Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Ultrasound and Hyperthermia Applications
- Advanced MRI Techniques and Applications
- Immune Cell Function and Interaction
- Food Quality and Safety Studies
- Adipose Tissue and Metabolism
- Diabetes and associated disorders
- Chronic Kidney Disease and Diabetes
Keimyung University
2014-2025
Korea University
2020-2024
Charles River Laboratories (United States)
2023-2024
Chungnam National University Hospital
2023
Seoul National University Bundang Hospital
2022-2023
University of Washington
2012-2022
Kyungpook National University
2020
Seoul National University of Science and Technology
2019
Gachon University
2017
Dong-A University Hospital
2016
Most people start their day with a cup of coffee. Many would also finish daily work As such, coffee drinking is an important part modern life. It has been told that driving force for humans to develop science, because it alerting effect on the human brain. However, some report experiencing irregular heartbeat or headaches and are thus reluctant drink coffee, which suggests individual variation intolerance. The aim this review briefly summarize effects health.
Cerebrovascular disease is a potential risk factor for Alzheimer's (AD). Although acute cerebral hypoperfusion causes neuronal necrosis and infarction, chronic induces apoptosis in neurons, but its effects on the cognitive impairment are not clear. The purpose of this study was to evaluate AD pathology glucose metabolism. A model established by ligating common carotid arteries bilaterally adult male rats (CAL group). Sham-operated underwent same procedures without artery ligation (control At...
Mapping of tissue structure at the cellular, circuit, and organ-wide scale is important for understanding physiological biological functions. A bio-electrochemical technique known as CLARITY used three-dimensional anatomical phenotypical mapping within transparent intact tissues has been recently developed. This method provided a major advance in structure-function relationships circuits nervous system organs by using whole-body clearing. Thus, present study, we aimed to improve original...
Sirtuin 1 (Sirt1) is an essential modulator of cellular metabolism and has pleiotropic effects. It was recently reported that Sirt1 overexpression in kidney tubule ameliorates cisplatin-induced acute injury (AKI). However, whether pharmacological activation also a beneficial effect against the disease remains unclear. In this study, we aimed to evaluate SRT1720, potent specific activator Sirt1, could ameliorate AKI. We found SRT1720 treatment ameliorated renal failure histopathological...
Incretin-related drugs and sulfonylureas are currently used worldwide for the treatment of type 2 diabetes. We recently found that Epac2A, a cAMP binding protein having guanine nucleotide exchange activity toward Rap, is target both incretin sulfonylurea. This suggests possibility interplay between sulfonylurea through Epac2A/Rap1 signaling in insulin secretion. In this study, we examined combinatorial effects various on secretion activation signaling. A strong augmentation by combination...
Melatonin is well known to modulate the sleep-wake cycle. Accumulating evidence suggests that melatonin also has favorable effects such as anti-oxidant and anti-inflammatory properties in numerous disease models. It been reported therapeutic against cisplatin-induced acute kidney injury (AKI). However, mechanisms underlying action of on renal side-effects cisplatin therapy remain poorly understood. In this study, we showed treatment significantly ameliorates failure histopathological...
Corosolic acid (CA), a triterpenoid compound isolated from Lagerstroemia speciosa L. (Banaba) leaves, exerts anti-inflammatory effects by regulating phosphorylation of interleukin receptor-associated kinase (IRAK)-2 via the NF-κB cascade. However, protective effect CA against endotoxic shock has not been reported. LPS (200 ng/mL, 30 min) induced IRAK-1 and treatment with (10 μM) significantly attenuated this effect. In addition, also reduced protein levels NLRP3 ASC which are main components...
Few studies have been conducted on sex differences in the incidence, pathophysiology, and prognosis of gastric cancer (GC).To analyze GC characteristics according to patients who underwent surgical treatment for GC.A total 2983 diagnosed with adenocarcinoma received at Seoul National University Bundang Hospital between 2003 2017 were included. Baseline clinicopathological characteristics, histologic type GC, overall GC-specific survival rates, associated risk factors analyzed.Among patients,...
Glucokinase (GK), which phosphorylates d-glucose, is a major glucose sensor in β-cells for glucose-stimulated insulin secretion (GSIS) and promising new drug target type 2 diabetes (T2D). In T2D, pancreatic exhibit defective sensitivity, leads to impaired GSIS. Although glucagon-like peptide-1-(7–36)-amide (GLP-1) known enhance β-cell the effect of GLP-1 on GK activity still unknown. The present study demonstrated that pretreatment 30 min significantly enhanced glucose-dependent manner, with...
Atrial fibrillation (AF) can be a risk factor for development of significant tricuspid regurgitation (TR). We investigated which clinical and echocardiographic parameters were related to severity functional TR in patients with lone AF. A total 89 AF enrolled (75 ± 11 years; 48% male): 13 severe TR, 36 moderate 40 consecutive less than mild TR. Clinical measurements including right ventricular (RV) remodeling function evaluated. Patients more older had frequently persistent (each p < 0.001)....
With increasing life expectancy, the incidence of gastric cancer (GC) in older adults is increasing. This study analyzed differences GC characteristics according to age and sex among patients who underwent surgical treatment for GC.A total 2,983 diagnosed with adenocarcinoma at Seoul National University Bundang Hospital between 2003 2017 were classified into three groups: I (<65 years, n=1,680), II (60-74 n=919), III (≥75 n=384). We compared baseline clinical characteristics, pathological...
Given the central role of dendritic cells (DCs) in directing T-cell phenotypes, ability biomaterial-treated DCs to dictate autologous phenotype was investigated. In this study, we demonstrate that differentially directed and polarization, depending on biomaterial used pretreat DCs. Immature (iDCs) were derived from human peripheral blood monocytes treated with films alginate, agarose, chitosan, hyaluronic acid, or 75:25 poly(lactic-co-glycolic acid) (PLGA), followed by co-culture these T...
Prolonged hyperglycemia results in pancreatic β-cell dysfunction and apoptosis, referred to as glucotoxicity. Although both oxidative endoplasmic reticulum (ER) stresses have been implicated major causative mechanisms of glucotoxicity, the reciprocal importance between two remains be elucidated. The aim this study was evaluate differential effect stress ER on by employing melatonin which has free radical-scavenging antioxidant properties. As expected, β-cells exposed prolonged high glucose...
Accumulating evidence suggests that the pineal hormone melatonin displays protective effects against renal fibrosis, but mechanisms remain poorly understood. Here, we investigate effect of on transdifferentiation fibroblasts to myofibroblasts invoked by transforming growth factor-β1 (TGF-β1). Increased proliferation and activation interstitial after TGF-β1 treatment were attenuated pretreatment. Mechanistically, suppressed Smad2/3 phosphorylation nuclear co-localization their phosphorylated...
Caspase-1 is a proinflammatory caspase responsible for the proteolytic conversion of precursor forms interleukin-1 β to its active form and plays an important role in pathogenesis various inflammatory diseases. It was reported that genetic deficiency caspase-1 prevented cisplatin-induced nephrotoxicity. However, whether pharmacological inhibition also has preventive effect against kidney injury not been evaluated. In this study, we examined Ac-YVAD-cmk, potent caspase-1-specific inhibitor,...
Renal fibrosis is a common feature of chronic kidney disease and promising therapeutic target. However, there still limited treatment for renal fibrosis, so the development new anti-fibrotic agents urgently needed. Accumulating evidence suggest that oxidative stress endoplasmic reticulum (ER) play critical role in fibrosis. Carnosol (CS) bioactive diterpene compound present rosemary plants has potent antioxidant anti-inflammatory properties. In this study, we investigated potential effects...
The association between Helicobacter pylori (HP) infection and coronary heart disease (CHD) is controversial. This study aimed to investigate the effect of H. eradication on CHD, especially in terms age sex.From May 2003 March 2022, 4765 subjects with without CHD (median follow-up: 51 months) were prospectively enrolled. participants categorized into two groups: non-eradication. After propensity-score matching (PSM), was analyzed using Cox proportional hazards.There no significant...