A5088984317- Prostate Cancer Treatment and Research
- Metabolomics and Mass Spectrometry Studies
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Ginseng Biological Effects and Applications
- Peroxisome Proliferator-Activated Receptors
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Food Quality and Safety Studies
- Endoplasmic Reticulum Stress and Disease
- Sirtuins and Resveratrol in Medicine
- Pharmacological Effects of Natural Compounds
- Drug-Induced Hepatotoxicity and Protection
- Phytoplasmas and Hemiptera pathogens
- Tea Polyphenols and Effects
- Prostate Cancer Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Toxin Mechanisms and Immunotoxins
- RNA regulation and disease
- Sleep and related disorders
- Biochemical Analysis and Sensing Techniques
- Computational Drug Discovery Methods
- Regulation of Appetite and Obesity
- PARP inhibition in cancer therapy
Sungkyunkwan University
2023-2024
Kyungpook National University
2017-2023
Keimyung University
2013-2016
Prostate cancer (PCa) is the most commonly diagnosed genital in men worldwide. Around 80% of patients who developed advanced PCa suffered from bone metastasis, with a sharp drop survival rate. Despite great efforts, detailed mechanisms underlying castration-resistant (CRPC) remain unclear. Sirtuin 5 (SIRT5), an NAD+-dependent desuccinylase, hypothesized to be key regulator various cancers. However, compared other SIRTs, role SIRT5 has not been extensively studied. Here, we revealed...
Ethanol-induced fat accumulation, the earliest and most common response of liver to ethanol exposure, may be involved in pathogenesis diseases. Isoliquiritigenin (ISL), an important constituent Glycyrrhizae Radix, is a chalcone derivative that exhibits antioxidant, anti-inflammatory, phytoestrogenic activities. However, effect ISL treatment on lipid accumulation hepatocytes alcoholic hepatitis remains unclear. Therefore, we evaluated underlying mechanism ethanol-induced hepatic steatosis by...
Prolonged hyperglycemia results in pancreatic β-cell dysfunction and apoptosis, referred to as glucotoxicity. Although both oxidative endoplasmic reticulum (ER) stresses have been implicated major causative mechanisms of glucotoxicity, the reciprocal importance between two remains be elucidated. The aim this study was evaluate differential effect stress ER on by employing melatonin which has free radical-scavenging antioxidant properties. As expected, β-cells exposed prolonged high glucose...
Prostate cancer (PCa) is the most frequent found in males worldwide, and its mortality rate increasing every year. However, there are no known molecular markers for advanced or aggressive PCa, an urgent clinical need biomarkers that can be used prognosis prediction of PCa.
The increasing prevalence of type 2 diabetes mellitus (T2DM) is associated with the rapid spread obesity. Obesity induces insulin resistance, resulting in β-cell dysfunction and thus T2DM. Green tea extract (GTE) has been known to prevent obesity T2DM, but this effect still being debated. Our previous results suggested that circulating green gallated catechins (GCs) hinders postprandial blood glucose lowering, regardless reducing cholesterol absorption when GCs are present intestinal lumen....
The casein kinase 2 (CK2) complex has garnered extensive attention over the past decades as a potential therapeutic target for diverse human diseases, including cancer, diabetes, and obesity, due to its pivotal roles in eukaryotic growth, differentiation, metabolic homeostasis. While CK2 is also considered promising antifungal target, role fungal pathogens remains unexplored. In this study, we investigated functions regulatory mechanisms of Cryptococcus neoformans, major cause meningitis....
Sepsis-induced liver dysfunction (SILD) is a common event and strongly associated with mortality. Establishing causative link between protein post-translational modification diseases challenging. We studied the relationship among lysine acetylation (Kac), sirtuin (SIRTs), factors involved in SILD, which was induced LPS-stimulated HepG2 cells. Protein hyperacetylation observed according to SIRTs reduction after LPS treatment for 24 h. identified 1449 Kac sites based on comparative acetylome...
Alpha-amanitin (α-AMA) is a cyclic peptide and one of the most lethal mushroom amatoxins found in Amanita phalloides. α-AMA known to cause hepatotoxicity through RNA polymerase II inhibition, which acts DNA translocation. To investigate toxic signature beyond mechanisms, we used quantitative nanoflow liquid chromatography-tandem mass spectrometry analysis coupled with tandem tag labeling examine proteome dynamics Huh-7 human hepatoma cells treated concentrations α-AMA. Among 1828 proteins...
Ginseng (Panax ginseng Meyer) is commonly used as an herbal remedy worldwide. Few studies have explored the possible physiological changes in liver although patients often self-medicate with preparations, which may lead to exceeding recommended dose for long-term administration. Here, we analyzed hepatic proteins of mouse livers using quantitative proteomics after sub-chronic administration Korean red (KRG) extract (control group and 0.5, 1.0, 2.0 g/kg KRG) tandem mass tag (TMT) 6-plex...
Identifying the biological change from hormone-naïve prostate cancer to castration-resistant (CRPC) is a major clinical challenge for developing therapeutic agents. Although pathways that lead CRPC are not fully completely understood, recent evidence demonstrates androgen signaling often maintained through varied mechanisms. Androgen deprivation therapy (ADT) used as primary treatment preventing progression of (PCa). Here we investigated PCa tissues at each stage progression, benign...
Prostate cancer (PCa) is the most common among men worldwide. Most PCa cases are not fatal; however, outlook poor when spreads to another organ. Bone target organ in about 80% of patients who experience metastasis from a primary tumor. In present study, we characterized secretome PC3/nKR cells, which new subline PC3 cells that were originally isolated nude mice implanted with without anti-natural killer (NK) cell treatment. Wound healing and Transwell assays revealed had increased migratory...
Abstract The recently developed technologies that allow the analysis of each single omics have provided an unbiased insight into ongoing disease processes. However, it remains challenging to specify study design for subsequent integration strategies can associate sepsis pathophysiology and clinical outcomes. Here, we conducted a time-dependent multi-omics (TDMI) in sepsis-associated liver dysfunction (SALD) model. We successfully deduced relation Toll-like receptor 4 (TLR4) pathway with...
Sepsis is one of the life-threatening diseases worldwide. Despite continuous progress in medicine, specific mechanism sepsis remains unclear. A key strategy pathogens to use post-translational modification modulate host factors critical for infection. We employed global immunoprecipitation technology lysine acetylation (Kac), succinylation (Ksu), and malonylation (Kmal) first acylation (Kacy) analysis a cecum ligation puncture (CLP) model mouse. This was performed reveal pathogenic...
<h3>Abstract</h3> Background/Aim: Renal cell carcinoma (RCC) is one of the most commonly diagnosed cancers in world. Approximately 25-30% patients identified with initial kidney cancer will have metastasized tumors, thus 5-year survival rates for these are poor. Therefore, biomarker research required to identify and predict molecular signatures RCC. Materials Methods: To address this, we used a mass spectrometry (MS)-based proteomics approach proteins related clear RCC (ccRCC) tissues from...
Oculocutaneous albinism type 2 (OCA2) is an autosomal recessive disorder that results from mutations in the P gene, and has approximately 70% function of melanin biosynthesis melanocytes. While overwhelming majority pigmentation studies have focused on European populations, very little known about gene mechanisms affecting skin lightening Asian population. The main goal study was to test distribution three polymorphisms located a candidate OCA2, sample individuals Koreans (N=250). genetic...