A5072274535- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Diabetes Management and Research
- Cancer, Hypoxia, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Endoplasmic Reticulum Stress and Disease
- Diet, Metabolism, and Disease
- Food Quality and Safety Studies
- Pituitary Gland Disorders and Treatments
- Adipose Tissue and Metabolism
- Bone health and osteoporosis research
- Antioxidant Activity and Oxidative Stress
- Adrenal and Paraganglionic Tumors
- Growth Hormone and Insulin-like Growth Factors
- Adenosine and Purinergic Signaling
- Traditional Chinese Medicine Studies
- Healthcare and Venom Research
- Tea Polyphenols and Effects
- Biochemical Acid Research Studies
- Parkinson's Disease Mechanisms and Treatments
Keimyung University
2014-2025
Korea University
2021
Jeonbuk National University
2021
Samsung Medical Center
2021
Chungnam National University
2021
Kyungpook National University
2008
Type 2 diabetes is a metabolic disease with group of derangements and inflammatory reactants in the serum. Despite substantial public health implications, markers progression abdominal obesity are still needed to facilitate early detection treatment. In this study, we performed proteomic approach identify differential target proteins underlying patients obesity. Proteomic differences were investigated serum controls prediabetes or without by 2-DE combined MALDI-TOF-MS. Proteomics data...
Abstract The anti-diabetic drug, metformin, exerts its action through AMP-activated protein kinase (AMPK), and Sirtuin ( Sirt1 ) signaling. Insulin-like growth factor (IGF)-binding 2 (IGFBP-2) prevents IGF-1 binding to receptors, thereby contributing modulate insulin sensitivity. In this study, we demonstrate that metformin upregulates Igfbp-2 expression the AMPK-Sirt1-PPARα cascade pathway. liver of high fat diet, ob/ob , db/db mice, was significantly decreased compared levels in wild-type...
Background/Objectives: Data availability can affect the performance of AI-based early warning scores (EWSs). This study evaluated how extent missing data and imputation strategies influence predictive VitalCare-Major Adverse Event Score (VC-MAES), an EWS that uses last observation carried forward normal-value for values, to forecast clinical deterioration events, including unplanned ICU transfers, cardiac arrests, or death, up 6 h in advance. Methods: We analyzed real-world from 6039 patient...
We evaluated the achievement of low-density lipoprotein cholesterol (LDL-C) targets in patients with type 2 diabetes mellitus (T2DM) according to up-to-date Korean Diabetes Association (KDA), European Society Cardiology (ESC)/European Atherosclerosis (EAS), and American (ADA) guidelines.
Prolonged hyperglycemia results in pancreatic β-cell dysfunction and apoptosis, referred to as glucotoxicity. Although both oxidative endoplasmic reticulum (ER) stresses have been implicated major causative mechanisms of glucotoxicity, the reciprocal importance between two remains be elucidated. The aim this study was evaluate differential effect stress ER on by employing melatonin which has free radical-scavenging antioxidant properties. As expected, β-cells exposed prolonged high glucose...
Abdominal or visceral obesity is a well-known risk factor for metabolic diseases. However, whether abdominal significantly affects plasma lipid profile during the development of type 2 diabetes has not been fully elucidated. We investigated differences in concentrations 63 participants categorized into six groups (middle-aged Korean men); Normal, Pre-diabetes (pre-DM), and Diabetes mellitus (DM) with without (AO lean). The lipidomic profiles were determined by using liquid...
This report presents the status of diabetic neuropathy (DN) in Korea as determined using a National Health Insurance Service-National Sample Cohort (NHIS-NSC). Annual prevalences DN were estimated by age and gender descriptive statistics. Pharmacological treatments for also analyzed. The annual prevalence increased from 24.9% 2006 to 26.6% 2007, thereafter, gradually subsided 20.8% 2015. In most cases, pharmacological involved single drug, which accounted 91.6% total prescriptions commonly...
Abstract Sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) are effective hypoglycemic agents that can induce glycosuria. However, there increasing concerns they might diabetic ketoacidosis. This study investigated the effect of melatonin on SGTL2i‐induced ketoacidosis in insulin‐deficient type 2 (T2D) mice. The SGLT2i dapagliflozin reduced blood glucose level and plasma insulin concentrations T2D mice, but induced increases β‐hydroxybutyrate, acetoacetate, free fatty acid a decrease...
Adpsin is an adipokine that stimulates insulin secretion from β-cells and improves glucose tolerance. Its expression has been found to be markedly reduced in obese animals. However, it remains unclear what factors lead downregulation of adipsin the context obesity. Endoplasmic reticulum (ER) stress response activated various tissues under obesity-related conditions can induce transcriptional reprogramming. Therefore, we aimed investigate relationship between ER adipose during We observed...
The increasing prevalence of type 2 diabetes mellitus (T2DM) is associated with the rapid spread obesity. Obesity induces insulin resistance, resulting in β-cell dysfunction and thus T2DM. Green tea extract (GTE) has been known to prevent obesity T2DM, but this effect still being debated. Our previous results suggested that circulating green gallated catechins (GCs) hinders postprandial blood glucose lowering, regardless reducing cholesterol absorption when GCs are present intestinal lumen....
Background: Atherogenic dyslipidemia, which is frequently associated with type 2 diabetes (T2D) and insulin resistance, contributes to the development of vascular complications. Statin therapy primary approach dyslipidemia management in T2D, however, role non-statin remains unclear. Ezetimibe reduces cholesterol burden by inhibiting intestinal absorption. Fibrates lower triglyceride levels increase high-density lipoprotein (HDL-C) via peroxisome proliferator- activated receptor alpha...
Osteoporosis is a progressive bone disease that characterized by decrease in mass density and destruction of microstructure, which can lead to an increased risk fracture. Although many studies have been published about the relationship between end-stage renal osteoporosis, research on proteinuria prevalence osteoporosis still lacking.We assessed 91 postmenopausal women with type 2 diabetes who visited our hospital from January 2009 2012.Among patients, osteopenia was 35.2% (32 cases) 32.9%...
Abstract Aims To evaluate the effect of dapagliflozin on body composition such as total fat (BF) mass, abdominal visceral adipose tissue (VAT), and subcutaneous (SAT) areas compared with glimepiride in Korean patients type 2 diabetes. Materials Methods This was a 52‐week, multicentre, randomized, parallel‐group, open‐label, Phase IV (NCT02564926) study. Patients inadequate glycaemic control (glycated haemoglobin ≥7.0% <10.0%) metformin monotherapy (≥1000 mg/day) were randomized 1:1 to...
PurposeDyslipidemia is an important risk factor for cardiovascular disease (CVD). Statins are known to effectively reduce not only low-density lipoprotein cholesterol (LDL-C) level but also death and nonfatal myocardial infarction due coronary heart disease. The CVD from atherogenic dyslipidemia persists when elevated triglyceride (TG) reduced high-density (HDL-C) levels controlled with statin therapy. Therefore, statin/fenofibrate combination therapy more effective in reducing risk. Here,...
Polyglandular autoimmune syndrome is defined as multiple endocrine gland insufficiencies accompanied by diseases of the and nonendocrine system. After Schmidt introduced a case nontuberculosis adrenal dysfunction with thyroiditis in 1926, Neufeld polyglandular I, II, III subtypes 1980 their presentation occurrence age, heredity methods, relationship human leukocyte antigen, accompanying diseases. We report 32-year-old female type 1 diabetes mellitus that was treated insulin (36 units per...
See the article "Association of Protein Z with Prediabetes and Type 2 Diabetes (Endocrinol Metab 2021;36:637-46, Yun-Ui Bae et al.)" in Volume 36 on page 1147.See letter-reply 1149.
Summary Atherosclerosis is considered as an inflammatory disease, and carotid artery intima‐media thickness ( IMT ) plaque are generally used intermediated phenotype of atherosclerosis. The aim this study was to investigate whether associated with promoter region polymorphisms interleukin 10 IL ‐10 gene. We recruited 135 subjects from a rural area south‐eastern part S outh K orea. Three in the (−1082 A / G , −819 T C −592 were genotyped by pyrosequencing. Carotid measured at common arteries,...
We investigated proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations in individuals with normoglycemia, impaired fasting glucose (IFG), and tolerance (IGT). This was a pilot, cross-sectional study including 92 who had not been diagnosed or treated for diabetes. measured PCSK9 levels three groups of subjects; namely, normoglycemia (n=57), IFG (n=21), IGT (n=14). Individuals showed higher than those the normoglycemic group, highest serum found (55.25±15.29 ng/mL 63.47±17.78...