A5050598557- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Disease Prevention
- Diabetes Management and Research
- Diabetes and associated disorders
- Adrenal and Paraganglionic Tumors
- Diet, Metabolism, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neuroblastoma Research and Treatments
- Natural Antidiabetic Agents Studies
- Blood Pressure and Hypertension Studies
- Endoplasmic Reticulum Stress and Disease
- Health Systems, Economic Evaluations, Quality of Life
- Calcium signaling and nucleotide metabolism
- Cancer, Hypoxia, and Metabolism
- Antiplatelet Therapy and Cardiovascular Diseases
- Phytochemicals and Antioxidant Activities
- FOXO transcription factor regulation
- Circular RNAs in diseases
- Inflammatory Myopathies and Dermatomyositis
- Peripheral Nerve Disorders
- Muscle and Compartmental Disorders
- Indoor Air Quality and Microbial Exposure
Inje University Busan Paik Hospital
2011-2024
Inje University
2012-2022
Yonsei University
2011
Abstract Background This study aimed to evaluate the benefit of brachial-ankle pulse wave velocity (baPWV) as a noninvasive marker arterial stiffness for prediction all-cause and cause-specific mortality in patients with type 2 diabetes. Methods multicenter prospective observational analyzed 2308 diabetes between 2008 2018. The were categorized according quartiles baPWV. Cause was determined using death certificates patient clinical records. We estimated proportional rates from all causes,...
• In this study, we examined the biochemical and physiological functions of Nicotiana benthamiana S1 domain-containing Transcription-Stimulating Factor (STF) using virus-induced gene silencing (VIGS), cosuppression, overexpression strategies. STF : green fluorescent protein (GFP) fusion colocalized with sulfite reductase (SiR), a chloroplast nucleoid-associated also present in stroma. Full-length its domain preferentially bound to RNA, probably sequence-nonspecific manner. by VIGS or...
To investigate the environmental behavior of volatile organic compounds (VOCs) in urban areas, their concentrations were measured at four monitoring sites (namely, N, S, E, and W) Seoul, Korea (February to December 2009). A total 27 quantified that consist chemical groups: aromatic (AR), halogenated aromatic, paraffin, olefin. Results evaluated by focusing on these functional groups just mentioned summation term as VOC (TVOC) along with several individual species (mainly AR species, is,...
Several studies have reported that pravastatin can mitigate the progression of kidney disease, but limited evidence exists regarding its effects on function in Asian patients. This multicenter prospective observational study aimed to assess effect Korean patients with dyslipidemia and type 2 diabetes mellitus (T2DM) clinical practice. 48-week included 2604 2997 eligible T2DM who had available estimated glomerular filtration rate (eGFR) measurements. The primary endpoint was eGFR percent...
Melatonin is a hormone known as having very strong anti-oxidant property. Senescence biological state characterized by the loss of cell replication and changes consisting pro-inflammatory phenotype, leading to Associated Secretory Phenotype (SASP) which now regarded one fundamental processes many degenerative diseases. Increased division count induces senescence via DNA damage in response elevated Reactive Oxygen Species (ROS). We wanted test whether melatonin could reduce apoptosis stress...
Blood glucose level continuously fluctuates within a certain range in the human body. In diabetes patients, extent of such fluctuation is large, despite strict control blood glucose. has been shown to mediate more adverse effects on vascular endothelial cells and complications than chronic hyperglycemia, which explained as due oxidative stress. As few previous studies have reported intermittent hyperglycemia apoptosis function pancreatic beta cells, this study herein was performed...
Ginsenoside Rg3 has been proposed to mediate anti-diabetic effects, but their direct effect on pancreatic β cell viability and mechanisms are not clearly understood. Recent studies suggest that intermittent high glucose (IHG) could be more harmful cells than sustained glucose. There few reports about the of ginsenosideRg3 apoptosis proliferation against IHG.INS-1 were treated with alternative concentration or without ginsenoside Rg3. Cell detected by Annexin V staining MTT assay. The...
Metformin and pioglitazone are two commonly prescribed oral hypoglycemic agents for diabetes. Recent evidence suggests that these drugs may contribute to bladder cancer. This study investigated molecular mechanism underlying effects of metformin in epithelial carcinogenesis type 2 The cells derived from human (HBlEpCs) were treated with or high glucose insulin. Cell viability proliferation evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay a...
There is limited information regarding the optimal third-line therapy for managing type 2 diabetes mellitus (T2DM) that inadequately controlled using dual combination therapy. This study assessed efficacy and safety of pioglitazone or glimepiride when added to metformin plus alogliptin treatment T2DM.This multicenter, randomized, active-controlled trial (ClinicalTrials.gov: NCT02426294) recruited 135 Korean patients with T2DM was alogliptin. The were then randomized also receive (15 mg/day)...
Data regarding the prescription status of individuals with diabetes are limited. This study was an analysis participants from relationship between cardiovascular disease and brachial-ankle pulse wave velocity in patients type 2 (REBOUND) Study, which a prospective multicenter cohort recruited eight general hospitals Busan, Korea. We performed this to investigate current Korean diabetic patients.
PURPOSE Androgens are steroid hormones that very important in the sexual development and maintenance of male reproductive system, also have diverse actions non-reproductive tissues, including potent antioxidant capacity. Type 2 diabetes mellitus is caused by tissue insulin resistance insufficient secretion from pancreatic β-cells. The progressive decline β-cells closely related with severity disease. We wanted to know whether dihydrotestosterone (DHT) can protect secreting apoptosis...
Background: Atherogenic dyslipidemia, which is frequently associated with type 2 diabetes (T2D) and insulin resistance, contributes to the development of vascular complications. Statin therapy primary approach dyslipidemia management in T2D, however, role non-statin remains unclear. Ezetimibe reduces cholesterol burden by inhibiting intestinal absorption. Fibrates lower triglyceride levels increase high-density lipoprotein (HDL-C) via peroxisome proliferator- activated receptor alpha...
Aim . The aim of this study was to evaluate the association between arterial stiffness and albuminuria glomerular filtration rate (GFR) in patients with type 2 diabetes mellitus. Methods This multicenter cohort analyzed 2613 diabetes. Brachial-ankle pulse wave velocity (baPWV) used as a noninvasive marker stiffness. Additionally, were categorized into four groups according their albumin-to-creatinine ratio (ACR, normoalbuminuria versus albuminuria) estimated GFR (eGFR, <60 mL/min/1.73 m...
Background/Aims β-Cell apoptosis caused by increased endoplasmic reticulum (ER) stress is an important pathogenic component of type 2 diabetes mellitus. In theory, sulfonylureas, used for the treatment diabetes, can contribute to ER stress. We assessed changes in pancreatic β-cells under glucotoxic or glucolipotoxic conditions using low concentrations sulfonylurea, glibenclamide (GB). Methods Low GB (10 100 nM) were added INS-1 cells cultured conditions. The degree viability, level and...
To evaluate the safety and effectiveness of empagliflozin in routine clinical settings, we collected assessed profiles Korean patients with type 2 diabetes mellitus.This was a post-marketing surveillance study 10 25 mg. Information on adverse events drug reactions (ADRs) as data sets. Available outcomes, including glycosylated hemoglobin (HbA1c) level, fasting plasma glucose, body weight, blood pressure, were assessed.The incidence rate ADRs 5.14% dataset (n=3,231). Pollakiuria, pruritis...
Background β-cell death due to endoplasmic reticulum (ER) stress has been regarded as an important pathogenic component of type 2 diabetes. The possibility suggested that sulfonylurea, currently being used one the main oral hypoglycemic agents diabetes, increases ER stress, which could lead sulfonylurea failure. authors present study examined β-cells in a glucolipotoxic condition using glyburide (GB) environment mimicking Methods Apoptosis was induced by adding various concentrations GB...
In vitro experiments using only β-cell lines instead of islets are limited because pancreatic composed four different types endocrine cells. Several recent studies have focused on cellular interactions among these cell types, especially α- and β-cells. Because islet isolation needs time experience, we tested a simple co-culture system with Their morphology function were assessed by comparison to each single culture islets.α TC-6 cells β TC-1 maintained in Dulbecco's Minimal Essential Medium...
(123)I-Metaiodobenzylguanidine ((123)I-MIBG) scintigraphy is a widely used functional imaging tool with high degree of sensitivity and specificity in diagnosis pheochromocytoma. However, rare cases false positive reactions have been reported. A 67-year-old male patient was admitted epigastric pain. Abdominal computed tomography (CT) revealed heterogeneous left adrenal mass 6 cm diameter; following hormone testing, (123)I-MIBG performed to determine the presence pheochromocytoma, which...
Background Cognitive impairment and brain damage in diabetes is suggested to be associated with hypoglycemia. The mechanisms of hypoglycemia-induced neural death apoptosis are not clear reperfusion injury may involved. Recent studies show that glucose deprivation/reperfusion induced more neuronal cell than deprivation itself. forkhead box O (FOXO) transcription factors implicated the regulation survival, but their role cells remains unclear. We examined FOXO involvement phosphatidylinositol...
A 40-year-old woman presented with a left adrenal incidentaloma. Based on the presence of café-au-lait spots, cutaneous neurofibroma, and family history, she was diagnosed neurofibromatosis type 1 (NF1). Adrenal incidentaloma screening showed an elevated normetanephrine level; mass uptake I-123 meta-iodobenzylguanidine. She underwent adrenalectomy, pheochromocytoma diagnosed. One year later, results biopsy palpable in breast suggested invasive ductal carcinoma. The patient neoadjuvant...
Thyrotoxic periodic paralysis (TPP) is a disease characterized by sudden onset and muscle paralysis.It occurs in the setting of hypokalemia thyrotoxicosis.Cases TPP induced glucocorticoid such as prednisolone or methylprednisolone have been reported.We report on two patients, each whom received dexamethasone injection subsequently developed TPP.Both patients experienced sudden, flaccid both extremities after but recovered completely receiving potassium replacement.Laboratory results revealed...
To determine whether the twice-daily (BID) regimen is superior to once-daily (QD) for managing glycaemic variability by comparing effects of anagliptin 100 mg BID versus sitagliptin QD.A double-blinded, randomized, multicentre study was performed in 89 patients with type 2 diabetes treated metformin alone (6.5% < HbA1c 8.5%). Subjects were randomly assigned or QD a 1:1 ratio 12 weeks. Continuous glucose monitoring used measure mean amplitude excursion (MAGE) and postprandial time range (TIR)...