A5103414559- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Autophagy in Disease and Therapy
- Neurological Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Invertebrate Immune Response Mechanisms
- Phytochemicals and Antioxidant Activities
- Adipokines, Inflammation, and Metabolic Diseases
- Gout, Hyperuricemia, Uric Acid
- Diabetes and associated disorders
- Food Allergy and Anaphylaxis Research
- Food Quality and Safety Studies
- Adipose Tissue and Metabolism
- Neurobiology and Insect Physiology Research
- Macrophage Migration Inhibitory Factor
- Allergic Rhinitis and Sensitization
- Alzheimer's disease research and treatments
- Cannabis and Cannabinoid Research
- S100 Proteins and Annexins
- Neuroendocrine regulation and behavior
- Biochemical effects in animals
- Inflammasome and immune disorders
- Polyamine Metabolism and Applications
Keimyung University
2021
Daegu Gyeongbuk Institute of Science and Technology
2015-2021
Florey Institute of Neuroscience and Mental Health
2018
Medical University of Vienna
2012-2016
Gyeongsang National University
2013
Nambu University
2013
Michigan State University
2013
Macroautophagy/autophagy is a lysosome-dependent catabolic process for the turnover of proteins and organelles in eukaryotes. Autophagy plays an important role immunity inflammation, as well metabolism cell survival. Diverse immune inflammatory signals induce autophagy macrophages through pattern recognition receptors, such toll-like receptors (TLRs). However, physiological its signaling mechanisms microglia remain poorly understood. Microglia are phagocytic cells that resident central...
Abstract Unc-51-like autophagy activating kinase 1 (ULK1), a mammalian homolog of the yeast Atg1, has an essential role in induction. In nutrient and growth factor signaling, ULK1 activity is regulated by various posttranslational modifications, including phosphorylation, acetylation, ubiquitination. We previously identified glycogen synthase 3 beta (GSK3B) as upstream regulator insulin withdrawal-induced adult hippocampal neural stem cells. Here, we report that following withdrawal, GSK3B...
[Purpose] In the present study, we investigated effect of antecedent exercise on functional recovery and brain-derived neurotrophic factor (BDNF) expression following focal cerebral ischemia injury. [Subjects] The rat middle artery occlusion (MCAO) model was employed. Adult male Sprague-Dawley rats were randomly divided into 4 groups. Group I included untreated normal (n=10); II with III that performed treadmill (20 m/min) training after IV before (n=10) as well ischemia. At different time...
The normal development and optimal functioning of the brain requires a vigilant immune surveillance system to detect remove potential risk factors prevent infection tissue damage. Microglia are resident cells frontline defenders responsible for response brain. Resting microglia possess ramified morphology with numerous thin processes that continuously sample environment. In inflammatory signals, become activated transform their into thick, amoeboid-like shape. Activated proliferate, migrate...
[Purpose] In the present study, we investigated effect of antecedent exercise on functional recovery and brain-derived neurotrophic factor (BDNF) expression following focal cerebral ischemia injury. [Subjects] The rat middle artery occlusion (MCAO) model was employed. Adult male Sprague-Dawley rats were randomly divided into 4 groups. Group I included untreated normal (n=10); II with III that performed treadmill (20 m/min) training after IV before (n=10) as well ischemia. At different time...
매실식초 사입액에서 초기 매실액의 농도가 1~6%일 때는 높을수록 유도기가 짧아져 높은 초산생성능을 보이다가 6%를 넘어서면 길어져 초산생성능이 저하되는 경향을 보였다. 6%의 매실액을 함유한 사입액은 발효 5일째 9.2%의 최종 산도에 도달하였고, 다른 농도의 첨가구보다 산도를 3% 초산, 6% 알콜, 사입액 100 ㎖를 발효시킬 경우 표면적이 25 ㎠인 발효용기를 사용하는 것이 10 ㎠와 50 ㎠의 발효용기에 배양한 것보다 초산 생성능이 우수함을 확인하였다. 또한 매실액 사입액을 진탕 발효시켰을 정치 발효에 비해 길었고, 배양 9일째에 산도가 9.44%로 나타나서 약2.02% 낮게 나타나 이용한 초산발효에서는 진탕배양보다 배양이 더 효과적이었다. 매실식초의 유기산성분을 분석한 결과 주요 유기산은 acetic acid, succinic citric acid이었고 그 함량은 각각 6167.01, 347.04, 76.67 ㎎%이었다. 유리당은 glucose와 fructose로...
Until now, few groups reported the antifreeze activity of cyclic glycopeptides; however, tedious synthetic procedure is not amenable to study intensive structure relationship. A series N-linked glycopeptoids and glycopeptide have been prepared evaluate as a function peptide backbone cyclization methyl stereochemical effect on rigid Thr position. This has combined protocol with solid phase synthesis obtained significant quantities homogeneous glycopeptoids. Analysis revealed that our...
See the article "Association of Protein Z with Prediabetes and Type 2 Diabetes (Endocrinol Metab 2021;36:637-46, Yun-Ui Bae et al.)" in Volume 36 on page 1147.See letter-reply 1149.
The present study was aimed at determining the effect of physical training on glutamate transporter activity in a middle cerebral artery occlusion (MCAO)-induced ischemia injury rat model.
Abstract Food allergies are a significant public health problem because they trigger life-threatening systemic allergic reactions. We have previously reported novel mouse model that uses transdermal exposure (TDE) to nut protein for sensitization followed by oral challenge (OC) elicit Here we evaluated the utility of this determine threshold doses hazelnut (HN). Groups mice (n=8-10/group) were sensitized with 2, 3, 4 or 5 TDE HN saline, OC induce anaphylaxis. The data demonstrated minimum...