Background and Purpose Atopic dermatitis (AD) is a multifactorial skin condition with complex interactions of innate adaptive immune responses. There are several existing therapies for AD, including topical glucocorticosteroids, emollients, phototherapies, calcineurin inhibitors immunosuppressants, such as cyclosporine A. Although these reduce inflammation, they also cause serious side effects. Therefore, it necessary to develop new therapeutic approaches AD treatment without studies on...

Sirtuin 1 (Sirt1) is an essential modulator of cellular metabolism and has pleiotropic effects. It was recently reported that Sirt1 overexpression in kidney tubule ameliorates cisplatin-induced acute injury (AKI). However, whether pharmacological activation also a beneficial effect against the disease remains unclear. In this study, we aimed to evaluate SRT1720, potent specific activator Sirt1, could ameliorate AKI. We found SRT1720 treatment ameliorated renal failure histopathological...

Propionibacterium acnes (P. acnes) cause inflammatory acne and play an important role in the pathogenesis of by inducing mediators. P. contributes to responses activating cells, keratinocytes sebocytes secrete pro‑inflammatory cytokines such as tumor necrosis factor‑α (TNF‑α), interleukin (IL)‑1β IL‑8. Bee venom has traditionally been used treatment certain immune‑related diseases. However, there not yet a robust trial prove therapeutic effect bee skin inflammation. The aim present study was...

Propionibacterium acnes (P. acnes) is a major contributing factor to the inflammatory component of acne. The many prescription medications for acne allow large number potential combination treatments. However, several antibiotics, apart from their antibacterial effects, exert side‑effects, such as suppression host responses. Purified bee venom (BV) natural toxin produced by honeybees (Apis mellifera L.). BV has been widely used traditional medicine various diseases. In present study,...

Liver fibrosis is characterized by changes in tissue architecture and extracellular matrix composition. affects not only hepatocytes but also the non-parenchymal cells such as hepatic stellate (HSCs), which are essential for maintaining an intact liver structure function. Transforming growth factor β1 (TGF-β1) a multifunctional cytokine that induces through activation of Smad signaling pathways. To improve new therapeutic approach, synthetic TGF-β1/Smad oligodeoxynucleotide (ODN) was used to...

Periodontitis is a chronic inflammatory disease that contributes to the destruction of gingiva. Porphyromonas gingivalis (P. gingivalis) can cause periodontitis via its pathogenic lipopolysaccharides (LPS). Melittin, major component bee venom, known have anti-inflammatory and antibacterial effects. However, role melittin in response has not been elucidated periodontitis-like human keratinocytes. Therefore, we investigated effects on P. LPS (PgLPS)-treated HaCaT keratinocyte cell line. The...

Abstract Kidney fibrosis is a common process of various kidney diseases leading to end‐stage renal failure irrespective etiology. Myofibroblasts are crucial mediators in through production extracellular matrix (ECM), but their origin has not been clearly identified. Many study proposed that epithelial and endothelial cells become myofibroblasts by dedifferentiation endothelial‐mesenchymal transition (EndoMT). TGF‐β1/Smad signaling plays role partly epithelial‐mensencymal (EMT) EndoMT. Thus,...

Atopic dermatitis (AD) is a chronic skin inflammatory disease characterized by recurrent eczema and itching. It caused poorly controlled immune response damage to the barrier. Purified bee venom (BV) natural toxin produced honeybees (Apis mellifera L.), well known for its anti‑inflammatory, analgesic anti‑cancer effects against various types of disease. However, treatment strategies based on anti‑inflammatory properties have not been adequately studied in AD. Thus, present study examined...

Acne vulgaris is the most common disease of pilosebaceous unit. The pathogenesis this complex, involving increased sebum production and perifollicular inflammation. Understanding factors that regulate important in identifying novel therapeutic targets for treatment acne. Bee Venom (BV) melittin have multiple effects including antibacterial, antiviral, anti-inflammatory activities various cell types. However, anti-lipogenic mechanisms BV not been elucidated. We investigated models...

Streptococcus pyogenes (S. pyogenes) bacteria cause almost all primary skin infections in humans. Bee venom (BV) and melittin (Mel) have multiple effects, including antibacterial anti-inflammatory activities. This study aims to demonstrate their effects on bacterial mouse infection using S. pyogenes. The dorsal was tape-stripped, then topically applied. BV or Mel were applied the lesion. tissues stained with hematoxylin eosin, while immunohistochemical staining performed anti-neutrophil....

Periodontitis is a chronic inflammatory disease that leads to destruction of tooth supporting tissues. Porphyromonas gingivalis (P. gingivalis), especially its lipopolysaccharides (LPS), one major pathogens cause periodontitis. Bee venom (BV) has been widely used as traditional medicine for various diseases. Previous studies have demonstrated the anti-inflammatory, anti-bacterial effects BV. However, direct role and cellular mechanism BV on periodontitis-like human keratinocytes not...

Hyperlipidemia is a chronic disorder that plays an important role in the development of cardiovascular diseases, type II diabetes, atherosclerosis, hypertension, and non-alcoholic fatty liver disease. Hyperlipidemias have created worldwide health crisis impose substantial burden not only on personal but also societies economies. Transcription factors sterol regulatory element binding protein (SREBP) family are key regulators lipogenic genes liver. SREBPs regulate lipid homeostasis by...

Abstract Atherosclerosis is a multifactorial and progressive disease in which the inflammatory reaction inflammation‐related factors play important roles at all stages. Modulation of NF ‐κ B S p1 expression may be targets for prevention treatment atherosclerotic vascular disease. To develop novel therapeutic approach atherosclerosis, we examined simultaneous suppression transcription regulate inflammation. We employed chimeric decoy oligodeoxynucleotide ( ODN ) containing consensus...

Atopic dermatitis (AD) is an inflammatory skin disease characterized by intense pruritus and relapsable eczematous lesions. The hallmarks of AD are defects in the epidermal barrier immunoglobulin E (IgE)-mediated sensitization to several environmental allergens, as well immune disorder mediated imbalance toward T-helper-2 response. Melittin, a major component bee venom, has been studied various diseases. However, beneficial effects melittin on mouse with AD-like symptoms have not explored....

Renal fibrosis is the principal pathological process underlying progression of chronic kidney disease that leads to end-stage renal disease. Melittin a major component bee venom, and it has anti-bacterial, anti-viral, anti-inflammatory properties in various cell types. Thus, this study examined therapeutic effects melittin on using unilateral ureteral obstruction (UUO) model. In addition, inflammation fibroblast cells were explored transforming growth factor-β1 (TGF-β1). Histological...

Cholestatic liver disease is characterized by the progressive destruction of biliary epithelial cells (BECs) followed fibrosis, cirrhosis and failure. Activated hepatic stellate (HSCs) portal fibroblasts are major cellular effectors enhanced collagen deposition in fibrosis. Apamin, an 18 amino acid peptide neurotoxin found apitoxin (bee venom), known to block Ca2+-activated K+ channels prevent carbon tetrachloride-induced In present study, we aimed ascertain whether apamin inhibits fibrosis...

Background: Bee venom (BV) has been widely investigated for potential medical uses.Recent inadvertent uses of BV based products have shown to mitigate signs fungal infections.However, the component mediating antifungal effect not identified.Objective: This investigation compares bee in its whole and partial forms evaluate possible responsible effect.Methods: Forty-eight plates inoculated with Trichophyton rubrum were allocated into four groups.The groups treated raw (RBV), melittin, apamin...

Atherosclerosis is a progressive chronic inflammatory condition that the cause of most cardiovascular and cerebrovascular diseases. The transcription factor nuclear factor‑κB (NF‑κB) regulates number genes involved in responses cells are critical to atherogenesis, signal transducer activator (STAT)3 key immunity inflammation. Decoy oligodeoxynucleotides (ODNs) bind sequence‑specific factors limit gene expression by interfering with vitro vivo. present study aimed investigate beneficial...