A5050785783- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Minimally Invasive Surgical Techniques
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Liver Disease and Transplantation
- Gastrointestinal Tumor Research and Treatment
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Treatments and Studies
- Esophageal and GI Pathology
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Virus-based gene therapy research
- RNA modifications and cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Hernia repair and management
- Pancreatitis Pathology and Treatment
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- Herpesvirus Infections and Treatments
- Genetic factors in colorectal cancer
- Viral-associated cancers and disorders
Ansan University
2011-2025
Molecular Oncology (United States)
2019-2024
Tianjin Medical University Cancer Institute and Hospital
2023-2024
Korea University
2013-2023
Korea University Medical Center
2008-2022
University of Chicago
2022
Memorial Sloan Kettering Cancer Center
2006-2019
Ewha Womans University
2018-2019
Ewha Womans University Medical Center
2019
Seoul St. Mary's Hospital
2018
No adjuvant therapy has been shown to extend the survival of patients with hepatocellular carcinoma (HCC) receiving curative treatment. We investigated whether injections activated cytokine-induced killer (CIK) cells (CD3+/CD56+ and CD3+/CD56- T CD3-/CD56+ natural cells) prolongs recurrence-free after for HCC.We performed a multicenter, randomized, open-label, phase 3 trial efficacy safety immunotherapy CIK (created by incubation patients' peripheral blood mononuclear interleukin 2 an...
Our earlier multicenter randomized controlled trial showed that adjuvant immunotherapy with cytokine-induced killer (CIK) cells resulted in longer recurrence-free survival (RFS) and overall (OS) as well patients who received curative treatment for hepatocellular carcinoma (HCC). In the present study, we determined if efficacy of CIK cell therapy continued after end repeated injections. We performed a follow-up study our preceding trial. included 226 patients: 114 group (injection 6.4 × 109...
Few studies have investigated the marginal accuracy of 3-unit zirconia fixed partial dentures (FPDs) fabricated by computer-aided design/computer-aided manufacturing (CAD/CAM) system.The purpose this study was to compare fit FPDs made using two CAD/CAM systems with that metalceramic FPDs.MATERIALS AND METHODS.Artificial resin maxillary central and lateral incisors were prepared for in yellow stone.This model duplicated epoxy die.On die, 15 three-unit per group (45 total): Group A, Everest...
518 Background: Notwithstanding the pressing need for adjuvant therapy hepatocellular carcinoma (HCC), most therapies, including atezolizumab/bevacizumab, have failed. Meanwhile, immunotherapy utilizing autologous cytokine-induced killer (CIK) cells HCC improved recurrence-free survival (RFS) in a previously reported randomized controlled trial (RCT) and real-world data. This study aimed to assess longer-term outcomes of RCT elucidate underlying mechanisms sustained effects CIK cell...
Background and purpose: Detecting atrial fibrillation (AF) in patients with embolic stroke of undetermined source (ESUS) is crucial for effective secondary prevention, particularly those left enlargement (LAE), as they have a higher risk subclinical AF. This study aims to evaluate compare the efficacy safety patch-type cardiac monitoring device (PCM) detecting AF ESUS LAE. Methods/design: prospective, multi-center, open-label, randomized, controlled, investigator-initiated trial will recruit...
Duchenne muscular dystrophy usually affects males. However, females are also affected in rare instances. Approximately 8% of female (DMD) carriers manifesting and have muscle weakness to some extent. We investigated the clinical features 3 patients with dystrophinopathy diagnosed by clinical, pathological, genetic studies at our neuromuscular disease clinic. The onset age symptoms varied (8-28 years). Muscle grade as follows: patient 1 showed asymmetrical bilateral proximal upper lower...
Background and Aims: The prognosis for patients with ampulla of Vater cancer is better than other periampullary cancers. aim the present study to determine clinicopathologic factors predictive survival recurrence in cancer. Material Methods: From 1991 2008, we identified reviewed 78 retrospectively. Clinicopathologic possibly influencing were statistically analyzed. Results: Pancreaticoduodenectomy was performed 68 2 underwent transduodenal ampullectomy. Hospital mortality 2.6%. 5-year rates...
Gastric cancers have poor overall survival despite recent advancements in early detection methods, endoscopic resection techniques, and chemotherapy treatments. Vaccinia viral therapy has had promising therapeutic potential for various a great safety profile. We investigated the efficacy of novel genetically-engineered vaccinia virus carrying human sodium iodide symporter (hNIS) gene, GLV-1 h153, on gastric its utility imaging with (99m)Tc pertechnetate scintigraphy ¹²⁴I positron emission...
Laparoscopic surgery is thought to reduce the postoperative immunologic effects of surgical trauma. The aim this study evaluate influence trauma on systemic inflammation and immune response in acute cholecystitis.Thirty-three patients with calculous cholecystitis were assigned laparoscopic cholecystectomy (LC, n=18) or open (OC, n=15). Blood samples obtained preoperatively day 1 (24 h after surgery) 3 (72 surgery), blood concentration C-reactive protein (CRP), leukocyte subpopulations, as...
Central nervous system dysfunction, such as hyperexcitation, irritability, and disturbance of consciousness, may occur in patients with thyrotoxicosis. There are also a few case reports seizures attributed to The objective the present study was determine prevalence that appeared be related thyrotoxic state thyrotoxicosis.We retrospectively determined clinical features 3382 hyperthyroidism. Among seizures, we excluded those other causes or history epilepsy. We did not exclude two whom later...
Current Status of Laparoscopic Liver Resection in KoreaSince laparoscopic liver resection was first introduced 2001, Korean surgeons have chosen a procedure as one the treatment options for benign or malignant disease.We distributed and analyzed nationwide questionnaire to members Surgery Study Group (KLLSG) order evaluate current status Korea.Questionnaires were sent 24 centers KLLSG.The consisted operative procedure, histological diagnosis lesions, indications resection, causes conversion...
Abstract Objective The aim of this study was to investigate the clinicopathological and immunohistochemical (including VEGF, Akt, HSP70, HSP20 expression) factors that affect overall disease-free survival HCC patients following surgical resection. Methods 234 with resection were enrolled. Clinicopathological data analyzed, staining performed on tissue microarray sections using anti-VEGF, anti-Akt, anti-HSP70, anti-HSP27 antibodies. Results 3- 5-year rates 86.5 81.54%, respectively....
Duodenal adenocarcinoma is a rare cancer, contributing <10 % of periampullary carcinoma. This study reviews the single center experience duodenal and analyzes clinical pathological factors to predict survival recurrence. The records 50 patients with who underwent surgical exploration or resection from 1995 2010 were reviewed retrospectively. Univariate multivariate analyses performed identify clinicopathological associated There 35 men 15 women, mean age 61 years. In analysis patients, R0 [p...
Inflammatory myofibroblastic tumor (IMT) of the stomach in adults is extremely rare, with unpredictable prognosis.We present a 55-year-old woman gastric IMT.She experienced sudden abdominal pain 4 d previously.Physical examination showed mild tenderness hypogastrium, but no palpable abnormal mass.Abdominal CT mass approximately 8 cm gastrocolic ligament.On laparoscopic exploration, unexpected hemoperitoneum 1.5 L blood was found, and an exophytic 10 cm, appeared from anterior wall body along...
Single port laparoscopic surgery has come to the forefront of minimally invasive surgery. For those familiar with conventional techniques, however, this type operation demands a different eye/hand coordination and involves unfamiliar working instruments. Herein, authors describe learning curve clinical outcomes single cholecystectomy for 150 consecutive patients benign gallbladder disease.All underwent using homemade glove by one five operators levels experiences The each operator was fitted...
Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare that accounts for about 1 to 2 per cent all pancreatic tumors. The aim this study was delineate clinicopathological characteristics and surgical outcomes solid pancreas. We retrospectively reviewed 18 patients who underwent surgery SPN between January 1, 2001 November 2010. patient group comprised 14 females four males median age at diagnosis 32.4 years (range 10∼68 years). Eleven were symptomatic time diagnosis. type selected...
Many studies which focus on the molecules and mechanisms related to characteristics of cancer have been performed. In particular, cell adhesion (CAMs) are known play a central role in cells vascular endothelial cells. this study, expression CAMs hepatocellular carcinoma (HCC) lines was analyzed correlated with various HCC lines. Eight human were used study. We ICAM-1, E-selectin integrin subunits by western blot analysis ELISA kit. estimated integrin-α5 using RT-PCR compare at gene level...
Abstract Background Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Although some epidemiologic and etiologic differences between Asian Western HCC are known, detailed comparative studies with pathologic correlations have not been performed. Methods Paraffin sections resected specimens from Memorial Sloan‐Kettering Cancer Center Korea University Medical were used to construct tissue microarrays. Immunohistochemical staining microarray was performed using...