A5050067486- Advanced Glycation End Products research
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- Cardiac Fibrosis and Remodeling
- Organ Transplantation Techniques and Outcomes
- Heme Oxygenase-1 and Carbon Monoxide
- Cell Adhesion Molecules Research
- Drug-Induced Hepatotoxicity and Protection
- Liver Diseases and Immunity
- Tissue Engineering and Regenerative Medicine
- Bone and Dental Protein Studies
- Signaling Pathways in Disease
- Liver physiology and pathology
- Macrophage Migration Inhibitory Factor
- Hepatitis Viruses Studies and Epidemiology
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Protease and Inhibitor Mechanisms
- Dental Erosion and Treatment
- Proteoglycans and glycosaminoglycans research
- Microscopic Colitis
- Pharmacological Effects of Natural Compounds
- Angiogenesis and VEGF in Cancer
Universität Hamburg
2014-2025
University Medical Center Hamburg-Eppendorf
2014-2025
Columbia University
2012-2022
Baylor College of Medicine
2006-2008
Houston Methodist
2006-2007
Methodist Hospital
2006
We previously described a mouse model of fibrotic ischemia/reperfusion cardiomyopathy (I/RC) arising from daily, brief coronary occlusion. One characteristic I/RC was the prolonged elevation monocyte chemoattractant protein 1 (MCP-1), which obligate to its phenotype and may contribute uptake bloodborne cells. Here we describe in hearts population small spindle-shaped fibroblasts that were highly proliferative expressed collagen I α-smooth muscle actin (myofibroblast markers), CD34 (a...
In contrast to microbially triggered inflammation, mechanisms promoting sterile inflammation remain poorly understood. Damage-associated molecular patterns (DAMPs) are considered key inducers of following cell death, but the relative contribution specific DAMPs, including high-mobility group box 1 (HMGB1), is ill defined. Due postnatal lethality Hmgb1-knockout mice, role HMGB1 in and disease processes vivo remains controversial. Here, using conditional ablation strategies, we have...
Abstract Infarct healing is dependent on an inflammatory reaction that results in leukocyte infiltration and clearance of the wound from dead cells matrix debris. However, optimal infarct requires timely activation “stop signals” suppress mediator synthesis mediate resolution infiltrate, promoting formation a scar. A growing body evidence suggests interactions involving transmembrane receptor CD44 may play important role inflammation migration fibroblasts injured tissues. We examined...
Cell death is a key driver of disease progression and carcinogenesis in chronic liver (CLD), highlighted by the well-established clinical correlation between hepatocellular risk for development cirrhosis carcinoma (HCC). Moreover, sufficient to trigger fibrosis HCC mice. However, pathways through which cell drives CLD remain elusive. Here, we tested hypothesis that high-mobility group box 1 (HMGB1), damage-associated molecular pattern (DAMP) with roles acute injury, may link injury responses...
Fibrosis contributes to ~45% of deaths in western countries. In chronic liver disease, fibrosis is a major factor determining outcomes, but efficient antifibrotic therapies are lacking. Although platelet-derived growth and transforming factor–β constitute key fibrogenic mediators, they do not account for the well-established link between cell death liver. Here, we hypothesized that damage-associated molecular patterns (DAMPs) may epithelial fibrogenesis injured DAMP receptor screening...
Background & Aims: Clinically-significant portal hypertension (CSPH) in liver cirrhosis patients can lead to refractory ascites. A transjugular-intrahepatic-portosystemic shunt (TIPS) treats CSPH but may cause overt hepatic encephalopathy (oHE). Our aim was determine the optimal reduction of pressure gradient (PPG) via TIPS control ascites without raising oHE risk. Approach: This multicenter study screened 1509 from three European centers (Hannover, Vienna, Hamburg) undergoing...
Acute-on-chronic liver failure (ACLF) is a severe complication of cirrhosis associated with excess short-term mortality rates. Orthotopic transplantation (OLT) potentially life-saving therapeutic modality for acute-on-chronic patients, but selection transplant candidates an acceptable post-transplant outcome difficult.To assess the risk in patients ACLF, and to determine parameters that predict survival this patient cohort.We retrospectively analysed all 250 who underwent their first between...
Regenerative responses predispose tissues to tumor formation by largely unknown mechanisms. High-mobility group box 1 (HMGB1) is a danger-associated molecular pattern contributing inflammatory pathologies. We show that HMGB1 derived from keratinocytes, but not myeloid cells, delays cutaneous wound healing and drives formation. In wounds of mice lacking selectively in marked reduction neutrophil extracellular trap (NET) observed. Pharmacological targeting or NETs prevents skin tumorigenesis...
Interleukin-10 (IL-10) exerts potent anti-inflammatory actions and modulates matrix metalloproteinase expression. We hypothesized that endogenous IL-10 may regulate infarct healing left ventricular remodeling by promoting resolution of the post-infarction inflammatory response modulating extracellular metabolism.IL-10 null wildtype (WT) mice underwent reperfused infarction protocols. compared remodeling-associated parameters between IL-10-/-and WT infarcts. In addition, we studied effects on...
Among patients with cirrhosis, candidate selection and timing of liver transplantation (LT) remain problematic. Acute-on-chronic failure (ACLF) is a severe complication cirrhosis excessive short-term mortality rates under conservative therapeutic measures. The role LT in the management ACLF uncertain.To assess impact on post-LT survival long-term graft function, morbidity quality life (QoL).We retrospectively analysed all undergoing at our institution between 01/2009 12/2014. Median...
Repetitive brief ischemia and reperfusion (I/R) is associated with ventricular dysfunction in pathogenesis of murine ischemic cardiomyopathy human hibernating myocardium. We investigated the role matricellular protein osteopontin-1 (OPN) model repetitive I/R. One 15-min LAD-occlusion followed by was performed daily over 3, 5, 7 consecutive days C57/Bl6 wildtype- (WT-) OPN −/− -mice (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
of Liverpool had data integrity concerns regarding the mass spectrometry contributed by Daniel J. Antoine, shown in Figures 3B and 5A this paper.The authors have also identified errors figure labels for 5H 6D.The provided a corrected version article description changes below.In our published work, we reported that hepatocyte-derived HMGB1 links cell death to progenitor responses hepatocarcinogenesis chronic liver disease (CLD).We based conclusions on extensive animal studies, including...
Abstract Background High-mobility group box protein 1 [HMGB1] is a ubiquitous nucleoprotein with immune-regulatory properties following cellular secretion or release in sterile and infectious inflammation. Stool serum HMGB1 levels correlate colitis severity colorectal cancer [CRC] progression, yet recent reports indicate that mainly operates as an intracellular determinant of enterocyte fate during colitis, investigations into the roles CRC are lacking. Methods Using mice conditional...
Background & Aims Current guidelines recommend immunosuppressive treatment (IT) in patients with primary sclerosing cholangitis (PSC) and elevated aminotransferase levels more than five times the upper limit of normal serum IgG-levels above twice normal. Since there is no evidence to support this recommendation, we aimed assess criteria that guided clinicians clinical practice initiate IT previously diagnosed PSC. Methods This a retrospective analysis 196 PSC from seven German hepatology...