A5078998887- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- HIV-related health complications and treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nitric Oxide and Endothelin Effects
- Pharmaceutical Economics and Policy
- Cardiac Ischemia and Reperfusion
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Cardiac Fibrosis and Remodeling
- Cancer, Lipids, and Metabolism
- Protease and Inhibitor Mechanisms
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Signaling Pathways in Disease
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 Clinical Research Studies
- Coronary Interventions and Diagnostics
- Eicosanoids and Hypertension Pharmacology
- Sepsis Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
Johns Hopkins Medicine
2016-2025
Johns Hopkins University
2016-2025
Johns Hopkins Hospital
2018-2024
University of Baltimore
2019
Medical College of Wisconsin
2010-2016
University of Louisville
2013
Lung Institute
2013
Jewish Hospital
2013
Harvard University
2007-2009
Baylor College of Medicine
2008-2009
Cardiac interstitial fibrosis plays an important role in the pathogenesis of ischemic cardiomyopathy, contributing to systolic and diastolic dysfunction. We have recently developed a mouse model fibrotic noninfarctive cardiomyopathy due brief repetitive myocardial ischemia reperfusion. In this model, changes are preceded by marked selective induction CC chemokine monocyte chemoattractant protein-1 (MCP-1). hypothesized that MCP-1 may mediate remodeling through recruitment mononuclear cells...
Elevated lipoprotein(a) [Lp(a)] is associated with atherosclerotic cardiovascular disease, yet little known about Lp(a) testing patterns in real-world practice. The objective of this analysis was to determine how used clinical practice comparison low density lipoprotein cholesterol (LDL-C) alone, and whether elevated level subsequent initiation lipid-lowering therapy (LLT) incident (CV) events.This an observational cohort study, based on lab tests administered between Jan 1, 2015 Dec 31,...
Rationale: Interferon-γ-inducible protein (IP)-10/CXCL10, an angiostatic and antifibrotic chemokine with important role in T-cell trafficking, is markedly induced myocardial infarcts, may regulate the reparative response. Objective: To study of IP-10 cardiac repair remodeling. Methods Results: We studied IP-10-null wild-type (WT) mice undergoing reperfused infarction protocols examined effects on fibroblast function. IP-10-deficient WT animals had comparable acute infarct size. However,...
Background PCSK9 (proprotein convertase subtilisin/kexin type 9) is well recognized for its important role in cholesterol metabolism. Elevated levels are associated with increased cardiovascular risk and inhibition antibodies (PCSK9i) lowers events patients coronary artery disease. also elevated people living HIV (PLWH) those dyslipidemia. Because PLWH impaired endothelial function, a barometer of vascular health, we tested the hypothesis that PCSK9i improves function dyslipidemia without...
Endothelial cystathionine γ-lyase (CSEγ) contributes to cardiovascular homeostasis, mainly through production of H 2 S. However, the molecular mechanisms that control CSEγ gene expression in endothelium during diseases are unclear. The aim current study is determine role specific histone deacetylases (HDACs) regulation endothelial CSEγ. Reduced mRNA and protein abundance were observed human aortic cells (HAEC) exposed oxidized LDL (OxLDL) aortas from atherogenic apolipoprotein E knockout...
Diabetic heart disease is associated with tetrahydrobiopterin oxidation and high arginase activity, leading to endothelial nitric oxide synthase dysfunction. Sepiapterin (SEP) a precursor, L-citrulline (L-Cit) converted substrate, L-arginine. Whether SEP L-Cit are effective at reducing diabetic not known. The present study examined the effects of on cardiomyopathy ischemia/reperfusion injury in obese type 2 mice.Db/db C57BLKS/J mice 6 8 weeks age received vehicle, SEP, or orally alone...
Background HIV + people are at increased risk of coronary artery disease, but the responsible mechanisms incompletely understood. Proprotein convertase subtilisin/kexin type 9 ( PCSK 9) is traditionally recognized for its importance in cholesterol metabolism; however, recent data suggest an additional, low-density lipoprotein receptor-independent adverse effect on endothelial cell inflammation and function. We tested hypotheses that levels abnormal function related to serum individuals....
Severe coronavirus disease-19 (COVID-19) is characterized by vascular inflammation and thrombosis. We others have proposed that the inflammatory response to infection activates endothelial cells, leading release of pro-thrombotic proteins. These mediators can trigger obstruction pulmonary microvasculature, worsening oxygenation, acute respiratory distress syndrome, death. In current study, we tested hypothesis higher levels biomarkers released from cells are associated with worse oxygenation...
Abstract Aims Lipoprotein(a) [Lp(a)] levels are predominantly genetically determined and repeat measurements generally considered unlikely to be clinically useful. However, the temporal variation of Lp(a) is not well characterized. Our aim was determine intra-individual variability whether a repeated measure reclassified Lp(a)-specific cardiovascular risk using European Atherosclerosis Society (EAS) consensus statement categories. Methods results This retrospective cohort study analysed...
Normal endothelial cell dependent vascular smooth muscle function is mediated by nitric oxide (NO), which stimulates soluble guanylyl cyclase (sGC) production of the second messenger cyclic guanosine monophosphate (cGMP) leading to increased protein kinase G (PKG) activity and relaxation. NO bioavailability impaired in high glucose (HG). We tested hypothesis that sGC sensitizer vericiguat reverses HG-mediated decreased two experimental models, human aortic cells (HVSMCs) isolated mouse...
Interleukin-10 (IL-10) exerts potent anti-inflammatory actions and modulates matrix metalloproteinase expression. We hypothesized that endogenous IL-10 may regulate infarct healing left ventricular remodeling by promoting resolution of the post-infarction inflammatory response modulating extracellular metabolism.IL-10 null wildtype (WT) mice underwent reperfused infarction protocols. compared remodeling-associated parameters between IL-10-/-and WT infarcts. In addition, we studied effects on...
COVID-19 is characterized by vascular inflammation and thrombosis, including elevations in P-selectin, a mediator of released endothelial cells. We tested the effect P-selectin inhibition on biomarkers thrombosis patients with COVID-19. Hospitalized moderate were randomly assigned to receive either placebo or crizanlizumab, inhibitor, double-blind fashion. Crizanlizumab reduced levels 89%. increased D-dimer 77% decreased prothrombin fragment. There no significant differences between...
Lipoprotein(a) [Lp(a)] levels are generally constant throughout an individual's lifetime, and current guidelines recommend that a single measurement is sufficient to assess the risk of coronary artery disease (CAD). However, it unclear whether Lp(a) in individuals with acute myocardial infarction (MI) indicative level six months following event.Lp(a) were obtained from non-ST-elevation (NSTEMI) or ST-elevation (STEMI) (n = 99) within 24 h hospital admission after months, who enrolled two...