A5077156017- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Liver physiology and pathology
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- T-cell and B-cell Immunology
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Peptidase Inhibition and Analysis
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- Bioactive Compounds and Antitumor Agents
- Fibroblast Growth Factor Research
- Calcium signaling and nucleotide metabolism
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Circadian rhythm and melatonin
- Mathematical Biology Tumor Growth
- Endoplasmic Reticulum Stress and Disease
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
Klinikum rechts der Isar
2022-2024
Technical University of Munich
2022-2024
Columbia University
2020-2022
SUNY Downstate Health Sciences University
2018
State University of New York
2018
Cancer-associated fibroblasts (CAF) may exert tumor-promoting and tumor-suppressive functions, but the mechanisms underlying these opposing effects remain elusive. Here, we sought to understand potentially functions by interrogating functional relationships among CAF subtypes, their mediators, desmoplasia, tumor growth in a wide range of types metastasizing liver, most common organ site for metastasis. Depletion hepatic stellate cells (HSC), which represented main source mice patients our...
Fibrosis contributes to ~45% of deaths in western countries. In chronic liver disease, fibrosis is a major factor determining outcomes, but efficient antifibrotic therapies are lacking. Although platelet-derived growth and transforming factor–β constitute key fibrogenic mediators, they do not account for the well-established link between cell death liver. Here, we hypothesized that damage-associated molecular patterns (DAMPs) may epithelial fibrogenesis injured DAMP receptor screening...
In patients with pancreatic ductal adenocarcinoma (PDAC), intratumoural and intertumoural heterogeneity increases chemoresistance mortality rates. However, such morphological phenotypic diversities are not typically captured by organoid models of PDAC. Here we show that branched organoids embedded in collagen gels can recapitulate the landscape seen murine human PDAC, pronounced molecular is governed defined transcriptional programmes (notably, epithelial-to-mesenchymal plasticity),...
ABSTRACT Abscisic acid (ABA) has shown anti-inflammatory and immunoregulatory properties in preclinical models of diabetes inflammation. Herein, we studied the effects ABA on angiogenesis, a strictly controlled process that, when dysregulated, leads to severe angiogenic disorders including vascular overgrowth, exudation, cellular inflammation organ dysfunction. By using 3D sprouting assay, show that effectively inhibits migration, growth expansion endothelial tubes without affecting cell...