A5100724797- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Stress Responses and Cortisol
- Metabolism, Diabetes, and Cancer
- Skin Protection and Aging
- Biological and pharmacological studies of plants
- Neuroscience and Neuropharmacology Research
- Sphingolipid Metabolism and Signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Genomics, phytochemicals, and oxidative stress
- Neuroinflammation and Neurodegeneration Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Biochemical Analysis and Sensing Techniques
- Musculoskeletal pain and rehabilitation
- Immune Response and Inflammation
- Stroke Rehabilitation and Recovery
- Bee Products Chemical Analysis
- Bone health and osteoporosis research
- Acute Ischemic Stroke Management
- Adipose Tissue and Metabolism
- Dementia and Cognitive Impairment Research
- Biochemical effects in animals
- Phytoestrogen effects and research
- Hormonal Regulation and Hypertension
- Medicinal Plants and Neuroprotection
Korea Food Research Institute
2021-2024
Hallym University
2007-2023
Kangdong Sacred Heart Hospital
2023
Chonbuk National University Hospital
2010-2020
Jeonbuk National University
2004-2019
Korea Institute of Sport Science
2018
Yeoju University
2016
Chonnam National University
2011-2014
Hallym Polytechnic University
2012-2013
Yonsei University
2012
Early intervention using dietary supplements may be effective in alleviating cognitive impairment among individuals with mild (MCI). This study investigated the efficacy and safety of Lactobacillus plantarum C29-fermented soybean (DW2009) as a nutritional supplement for enhancement. One hundred MCI were randomly assigned to take DW2009 (800 mg/day, n = 50) or placebo 12 weeks. The primary outcome measure was change composite score functions related memory attention, measured by computerized...
Red ginseng is prepared by steaming raw ginseng, a process believed to increase the pharmacological efficacy. Further bioconversion of red through fermentation known its intestinal absorption and bioactivity, diminishes toxicity ginseng's metabolite. This study was conducted investigate effects daily supplementation with fermented (FRG) on glycemic status in subjects impaired fasting glucose or type 2 diabetes. four-week long, randomized, double-blind, placebo-controlled trial. Forty-two...
The prevalence of metabolic syndrome, hypertension, and diabetes has been increasing rapidly in Korea. rate increase paralleled the replacement Korean traditional diets (KTD), which emphasize vegetables fermented foods, with western style dietary patterns that are rich animal foods saturated fat. We aimed to investigate efficacy KTD controlling fasting plasma glucose, blood pressure, cardiovascular disease risk factors hypertensive type 2 diabetic (T2D) patients. Forty-one patients (61.8±1.5...
Objectives The purpose of this study is to verify the serial multiple mediating effect job stress and happiness in relationship between director's emotional leadership teacher crafting. Methods A questionnaire survey on leadership, crafting, happiness, was conducted 202 kindergarten teachers working City B. collected data ana lyzed using SPSS 26.0 PROCESSmecro 4.2's Model 6 mediation effect. Results main research results are as follows. First, showed that had a positive while neg ative...
Abstract Background Previous animal studies have shown that Curcuma longa (turmeric) improves liver function. Turmeric may thus be a promising ingredient in functional foods aimed at improving The purpose of the study is to investigate hepatoprotective effect fermented turmeric powder (FTP) on function subjects with elevated alanine transaminase (ALT) levels. Methods A randomised, double-blind, placebo-controlled trial was conducted between November 2010 and April 2012 clinical center for...
The effects of actiponin was investigated, a heat-processed Gynostemma pentaphyllum extract, on body weight, fat loss, and metabolic markers Korean participants in 12-week, randomized, double-blind, placebo-controlled clinical trial.Obese (BMI ≥ 25 kg m(-2) WHR 0.90 for male or 0.85 female) who had not been diagnosed with any disease met the inclusion criteria were recruited this study. 80 subjects randomly divided into (n = 40, 450 mg day(-1) ) placebo 40) groups. Outcomes included...
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family and potent inducer apoptosis. TRAIL has been shown to effectively limit tumor growth in vivo without detectable cytotoxic side-effects. Interferon (IFN)-gamma often modulates anticancer activities members including TRAIL. However, little known about mechanism. To explore mechanism, A549, HeLa, LNCaP, Hep3B HepG2 cells were pretreated with IFN-gamma, then exposed IFN-gamma pretreatment...
Steamed ginger ethanolic extract (SGE) is a product with high 6-shogaol contents and thought to be more potent than other products. We conducted 12-week, randomized, double-blind, placebo-controlled clinical trial determine the effects of SGE on weight body fat loss. Eighty healthy obese participants were recruited randomly divided into placebo groups. The outcome measures comprised indicators efficacy (body weight, mass index, composition, blood markers) safety. Following supplementation...
The present study aimed to determine the effect of black soy peptide supplementation on glucose control in subjects with prediabetes (impaired fasting or impaired tolerance) and newly diagnosed type 2 diabetes mellitus (DM). In this double-blind, placebo-controlled study, DM were randomly assigned placebo group intervention group. We determined serum concentrations glucose, hemoglobin A1c, insulin, free fatty acids, performed a 2-hour postload (2-hour PG) test, compared lipid profiles before...
The outermost layer of the skin, epidermis, is directly exposed to external stress (e.g., irradiation, allergens, and chemicals). Changes in epidermal conditions/environment response this could also influence conditions dermis, located beneath epidermis. Yet, whether/how any environment changes affect dermal functions has not been completely clarified.We employed ultraviolet irradiation B (UVB) (which hardly reaches dermis) as a model stress. Human keratinocytes human fibroblasts were...
The present study determined the effect of black soy peptide supplementation on body weight and fat in overweight/obese subjects. In a double-blind controlled trial, participants (n = 80) were randomized to either (the test group) or placebo group). Sixty-four people completed study, anthropometric parameters, serum inflammatory markers, leptin lipid profiles measured. After 6 weeks, group 35) had significant reductions (p 0.003) mass index (BMI) 0.004), 0.038). 12 they also < 0.001), BMI...
Ginsenosides are active compounds that beneficial to bone metabolism and have anti-osteoporosis properties. However, very few clinical investigations investigated the effect of ginseng extract (GE) on metabolism. This study aims determine GE improving arthritis symptoms in postmenopausal women with osteopenia. A 12-week randomized, double-blind, placebo-controlled trial was conducted. total 90 subjects were randomly divided into a placebo group, 1 g 3 group for 12 weeks based random 1:1:1...
Erectile dysfunction (ED) is a highly prevalent disorder that affects millions of men worldwide. ED now considered an early manifestation atherosclerosis, and consequently, precursor systemic vascular disease. This study was designed to investigate the effects male silkworm pupa powder (SWP) on levels nitric oxide synthase (NOS) expression, nitrite, glutathione (GSH); lipid peroxidation; libido; erectile response corpus cavernosum rat penis. We induced in animals by oral administration 20%...
The ethanol extract of Gynostemma pentaphyllum Makino leaves (EGP) has been reported recently to have anxiolytic effects on chronically stressed mice models. We aimed investigate the efficacy and safety EGP anxiety level in healthy Korean subjects under chronic stressful conditions. Double-blind, placebo-controlled trial. This study was conducted with 72 adults who had perceived stress a score State-Trait Anxiety Inventory (STAI) from 40 60. Participants were randomly assigned receive either...
Cardiovascular diseases are a global health burden with an increasing prevalence. In addition, various metabolic diseases, such as obesity, diabetes, and hypertension associated higher risk of cardiovascular diseases. Dietary strategies based on healthy foods have been suggested for the prevention or improvement Grains most widely consumed food worldwide, preventive effects whole grains (e.g., oats, barley, buckwheat) reported. The germ bran rich in compounds, including phytochemicals,...
GS-3K8 and GINST, both of which are modified ginseng extracts, have never been examined in terms their effectiveness for the prevention acute respiratory illness (ARI) humans. We conducted a pilot study to assess feasibility performing large-scale, randomized, controlled trial. This was double-blind, placebo-controlled, at single center from October 2014 March 2015. The 45 healthy applicants were randomly divided into (n = 15), GINST placebo groups 15). drug administered as capsule (500...
This randomized, double-blind, placebo-controlled trial examined whether the administration of ganglioside, an active ingredient deer bone extract, can improve working memory performance by increasing gray matter volume and functional connectivity in default mode network (DMN) individuals with subjective cognitive impairment. Seventy-five impairment were chosen to receive either ganglioside (330[Formula: see text][Formula: text]g/day or 660[Formula: text]g/day) a placebo for 8 weeks. Changes...
Abstract The effect of stress mediators following the period and addition time is a controversial issue until now. Thus, we aim to clarify differential effects single restraint (SS) or repeated (RS) on kainic acid (KA)‐induced neuronal death especially as addressing not only role glucocorticoid (Gc) its receptor but also signal pathway leading cAMP response element binding protein phosphorylation (pCREB) functional during stress. In present study, found that although RS did show any...