A5031117341- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- MicroRNA in disease regulation
- Characterization and Applications of Magnetic Nanoparticles
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Bone Tissue Engineering Materials
- Advanced Drug Delivery Systems
- Dendrimers and Hyperbranched Polymers
- Hydrogels: synthesis, properties, applications
- Curcumin's Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Silk-based biomaterials and applications
- biodegradable polymer synthesis and properties
- Molecular Biology Techniques and Applications
- Anodic Oxide Films and Nanostructures
- Phagocytosis and Immune Regulation
- Biopolymer Synthesis and Applications
- Advanced Cellulose Research Studies
- Drug-Induced Adverse Reactions
- Electron Spin Resonance Studies
- Graphene and Nanomaterials Applications
Chonnam National University
2011-2020
Chonnam National University Hospital
2011-2020
Gwangju University
2014-2020
Masonic Medical Research Laboratory
2019
Chonnam National University Hwasun Hospital
2011-2013
Weatherford College
2013
Dermal tissue engineering focuses on the restoration of diseased and damaged tissues by using a combination cells, biomaterials, bioactive molecules. Inorganic substances like zeolites, clay, mesoporous silica, metals, metal oxides are advanced materials used in wound healing research. They can improve structural stability bioactivity bio polymeric scaffolds. Zeolites, clays, silica act as suitable carriers for drug delivery when incorporated within scaffolds, serve ideal matrices promoting...
Exploring the possibility of using inorganic faujasites in tissue engineering scaffolds is a prospective approach regenerative medicine. Novel gelatin/hyaluronic acid (HA)/faujasite porous with low surface energy were fabricated by lyophilization. The pore size gelatin/HA scaffold was 50-2000 μm, whereas it greatly reduced to 10-250 μm after incorporation 2.4% (w/w) polymer matrix, GH(2.4%). Micro computed tomography analysis showed that porosity GH(2.4%) 90.6%. summative effect ideal for...
Non-invasive radiofrequency (RF) frequency may be utilized as an energy source to activate thermo-responsive nanoparticles for the controlled local delivery of drugs cancer cells. Herein, we demonstrate that 180 ± 20 nm sized curcumin encapsulated chitosan-graft-poly(N-vinyl caprolactam) containing iron oxide (Fe3O4-CRC-TRC-NPs) were selectively internalized in cells vivo. Using RF treatment at 80 watts 2 min, Fe3O4-CRC-TRC-NPs, dissipated heat 42 degrees C, which is lower critical solution...
Cancer gene therapy involves the replacement of missing or altered genes with healthy ones. In this paper, we have proposed tumor suppressor gene-carrying superparamagnetic iron oxide nanoparticles (SPIONs) for anti-cancer therapy. Thermally crosslinked SPIONs (TCL-SPIONs) were conjugated branched polyethylenimine (PEI 1800 Da) by EDC-NHS chemistry p53 plasmid DNA delivery. The morphology bPEI TCL-SPIONs (bPEI-TCL-SPION) and pDNA-loaded bPEI-TCL-SPION was measured using transmission electron...
RF responsive gold nanoparticles containing curcumin encapsulated chitosan-<italic>graft</italic>-poly(<italic>N</italic>-vinyl caprolactam) induced apoptosis on 4T1 breast cancer cells exposure.
Smooth muscle cells (SMCs) can grow over a stent surface and block blood flow through the stent, resulting in restenosis. MicroRNAs (miRNAs) are post-transcriptional regulators that contribute to cell proliferation, survival, metabolism. Several miRNAs, including miR-145, have been identified regulate vascular SMC proliferation down-regulated under conditions of proliferation. We hypothesized would be reduced or diminished if miR-145 expression was restored SMCs. designed method coat with...
In this study, we present nanofiber-mediated gene delivery for myocardial infarction (MI). Branched polyethylenimine cross-linked via disulfide bonds (ssPEI) complexed with vascular endothelial growth factor (VEGF) were immobilized on electrospun polycaprolactone (PCL)/polyethylenimine (PEI) nanofibers the local expression of VEGF angiogenic factor. We studied whether production from myoblast cells adhering has therapeutic potential MI. method, non-specific adsorption nanoparticles to...
Positively charged superparamagnetic iron oxide nanoparticle (SPION)-loaded polymersome was prepared in order to deliver genes the target sites, which monitored by magnetic resonance imaging (MRI), concomitantly. The transfection efficiency vitro tested treating CT-26 colon cancer cell line with luciferase-expressing plasmids/SPION complex. MRI also used check detectability of SPION and vivo. SPION-loaded polymersome, carrying genetic materials, delivered then accumulated at tumor site...
Polymersomes with different surface charges were synthesized from polysuccinimide (p) by introducing positively charged polyethylenimine (PEI-P), neutrally polyethylene glycol (PEG-P), and negatively glycine (GLY-P) to the polymer backbone (P). Then, polymersomes prepared super paramagnetic iron nanoparticles (SPIONs) obtain PEI-P encapsulating SPIONs (PEI-PS), PEG-P (PEG-PS), GLY-P (GLY-PS), respectively. The average particle sizes of GLY-PS, PEG-PS, PEI-PS analyzed dynamic light...