A5038025458- Free Radicals and Antioxidants
- Genomics, phytochemicals, and oxidative stress
- Antioxidant Activity and Oxidative Stress
- Cancer, Hypoxia, and Metabolism
- Ion Transport and Channel Regulation
- Drug Transport and Resistance Mechanisms
- Vitamin C and Antioxidants Research
- ATP Synthase and ATPases Research
- Cancer, Lipids, and Metabolism
- Retinoids in leukemia and cellular processes
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Phytochemicals and Antioxidant Activities
- Electrospun Nanofibers in Biomedical Applications
- Glutathione Transferases and Polymorphisms
- Toxin Mechanisms and Immunotoxins
- Redox biology and oxidative stress
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Eicosanoids and Hypertension Pharmacology
- Cancer therapeutics and mechanisms
- Sulfur Compounds in Biology
- Viral Infectious Diseases and Gene Expression in Insects
- Liver physiology and pathology
- Plant biochemistry and biosynthesis
Rudjer Boskovic Institute
2016-2025
Croatian Institute of Transfusion Medicine
2009
Aquaporin-5 (AQP5) is a membrane water channel widely distributed in human tissues that was found up-regulated different tumors and considered implicated carcinogenesis organs systems. Despite its wide distribution pattern physiological importance, AQP5 short-term regulation not reported mechanisms underlying involvement cancer are well defined. In this work, we expressed rat yeast investigated of gating, as AQP5's ability to facilitate H₂O₂ plasma diffusion. We can be gated by extracellular...
Aquaporin 3 (AQP3) is a peroxiporin, membrane protein that channels hydrogen peroxide in addition to water and glycerol. AQP3 expression also correlates with tumor progression malignancy is, therefore, potential target breast cancer therapy. In addition, epithelial growth factor receptor (EGFR) plays an important role cancer. Therefore, we investigated whether disruption of the lipid raft harboring EGFR could affect expression, conversely, silencing would EGFR/phosphoinositide-3-kinase...
Breast cancer is a heterogeneous disease with varying responses to therapies. While targeted treatments have advanced, conventional therapies inducing oxidative stress remain widely used. H2O2 has emerged as therapeutic candidate due its role in signaling and cell-function regulation. Its transport tightly regulated through peroxiporins such AQP5, expression of which linked poor prognosis metastatic spread, therapy resistance remains underexplored. This study examined AQP5’s the acute...
This study used malondialdehyde (MDA) determination by HPLC and enzymatic assays for total serum peroxides antioxidant capacity to evaluate oxidative stress in 47 healthy full-term small-for-gestational age (SGA) newborns vs 67 appropriate-for-gestational (AGA) newborns. Blood samples were collected at delivery from umbilical cord artery vein peripheral blood of the babies on third day after birth. mothers also compared with 29 normal non-pregnant women (NPW). Serum peroxide values...