A5058176482- Ion Transport and Channel Regulation
- Adipose Tissue and Metabolism
- ATP Synthase and ATPases Research
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Electrolyte and hormonal disorders
- Birth, Development, and Health
- Nematode management and characterization studies
- Biomarkers in Disease Mechanisms
- Magnesium in Health and Disease
- Plant Disease Management Techniques
- Pregnancy and preeclampsia studies
- Microbial metabolism and enzyme function
- Parasite Biology and Host Interactions
- Plant Pathogens and Fungal Diseases
- Genomics, phytochemicals, and oxidative stress
- Renal and related cancers
- Skin and Cellular Biology Research
- Legume Nitrogen Fixing Symbiosis
- Clinical Nutrition and Gastroenterology
- Chemical and Physical Studies
- Metalloenzymes and iron-sulfur proteins
- Marine Biology and Environmental Chemistry
- Lipid metabolism and biosynthesis
University of Lisbon
2015-2025
Institute for Medical Research
2022
Instituto Nacional de Investigação Agrária e Veterinária
2020
Reactive oxygen species (ROS), including H2O2, contribute to oxidative stress and may cause cancer initiation progression. However, at low concentrations, H2O2 can regulate signaling pathways modulating cell growth, differentiation, migration. A few mammalian aquaporins (AQPs) facilitate diffusion across membranes participate in tumorigenesis. AQP3 AQP5 are strongly expressed tissues AQP3-mediated transport has been related breast migration, but studies with human lacking. Here, we report...
Abstract Aquaporin‐3 (AQP3) is a membrane channel with dual aquaglyceroporin/peroxiporin activity, facilitating the diffusion of water, glycerol and H 2 O across cell membranes. AQP3 shows aberrant expression in melanoma its role adhesion, migration proliferation well described. Gold compounds were shown to modulate activity reduced associated toxicity, making them promising molecules for cancer therapy. In this study, we validated phenotype resulting from AQP3‐silencing two lines, MNT‐1...
Polyoxometalates (POMs) are of increasing interest due to their proven anticancer activities. Aquaporins (AQPs) were found be overexpressed in tumors bringing particular attention inhibitors as drugs. Herein, we report for the first time ability polyoxotungstates (POTs), such Wells–Dawson P2W18, P2W12, and P2W15, Preyssler P5W30 structures, affect aquaporin-3 (AQP3) activity impair melanoma cell migration. The tested POTs revealed inhibit AQP3 function with different effects, being most...
Aquaporin 3 (AQP3) is a peroxiporin, membrane protein that channels hydrogen peroxide in addition to water and glycerol. AQP3 expression also correlates with tumor progression malignancy is, therefore, potential target breast cancer therapy. In addition, epithelial growth factor receptor (EGFR) plays an important role cancer. Therefore, we investigated whether disruption of the lipid raft harboring EGFR could affect expression, conversely, silencing would EGFR/phosphoinositide-3-kinase...
Pancreatic cancer is one of the most lethal and challenging malignancies. Its severity primarily linked to constitutively activated mitogen-activated protein kinase (MAPK)/extracellular signal-regulated (ERK) pathway. Aquaporins (AQPs) are frequently overexpressed in pancreatic cancer, playing crucial roles cell signaling, consequently promoting migration, proliferation, invasion. Here, we investigate transcriptomics key players epithelial–mesenchymal transition (EMT) MAPK/ERK signaling...
Aquaporins are membrane channels responsible for the bidirectional transfer of water and small non-charged solutes across cell membranes. AQP3 AQP5 overexpressed in pancreatic ductal adenocarcinoma, playing key roles migration, proliferation, invasion. Here, we evaluated involvement biomechanical properties, cell-cell adhesion, following a loss-of-function strategy on BxPC-3 cells.Silencing was functionally validated by reduced permeability had implications slowing wound recovery. Moreover,...
Aquaporins (AQPs) are transmembrane channels that facilitate water and glycerol permeation through cell membranes. Recently, the channel AQP1 was suggested to contribute endothelial homeostasis cardiovascular health. Less is known about aquaglyceroporins expression its implication in disease (CVD). We have previously used cultured human cells under a hypomethylating environment study dysfunction activation, phenotype implicated establishment of atherosclerosis CVD. Here, we same model...
Glycerol is a key metabolite for lipid accumulation in insulin-sensitive tissues. We examined the role of aquaporin-7 (AQP7), main glycerol channel adipocytes, improvement brown adipose tissue (BAT) whitening, process whereby adipocytes differentiate into white-like unilocular cells, after cold exposure or bariatric surgery male Wistar rats with diet-induced obesity (DIO) (n = 229). DIO promoted BAT evidenced by increased hypertrophy, steatosis and upregulation lipogenic factors Pparg2,...
Browning of white adipocytes has been proposed as a powerful strategy to overcome metabolic complications, since brown are more catabolic, expending energy heat form. However, the biological pathways involved in browning process still unclear. Aquaglyceroporins sub-class aquaporin water channels that also permeate glycerol and body homeostasis. In adipose tissue, aquaporin-7 (AQP7) is most representative isoform, being crucial for adipocyte fully differentiation metabolism. The altered...
There is, at the present time, a great demand for chestnut rootstocks with improved resistance to Phytophthora cinnamomi Rands in nurseries. New genotypes are emerging from European breeding programs and production of thriving plants restore old orchards low yields due high incidence diseases, namely root rot, is necessary. Micropropagation useful technique clonal propagation. Nevertheless, vitro culture propagation genotype-dependent. Consequently, existing protocols may demonstrate poor...