A5020790810- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Click Chemistry and Applications
- Metal complexes synthesis and properties
- Catalytic Alkyne Reactions
- Ferrocene Chemistry and Applications
- Organometallic Complex Synthesis and Catalysis
- Asymmetric Hydrogenation and Catalysis
- Catalytic Cross-Coupling Reactions
- Dendrimers and Hyperbranched Polymers
- Probiotics and Fermented Foods
- Nanomaterials for catalytic reactions
- Nanocluster Synthesis and Applications
- Chemical Synthesis and Analysis
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Organometallic Compounds Synthesis and Characterization
- Nanoplatforms for cancer theranostics
- ATP Synthase and ATPases Research
- Gut microbiota and health
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Supramolecular Chemistry and Complexes
- Boron Compounds in Chemistry
- Enzyme function and inhibition
- Single-cell and spatial transcriptomics
University of Vienna
2024-2025
Technical University of Munich
2021-2024
Cultech (United Kingdom)
2022-2024
Cardiff University
2019-2023
University of Bath
2020
Engineering and Physical Sciences Research Council
2020
With the aim of exploiting use organometallic species for efficient modification proteins through C-atom transfer, gold-mediated cysteine arylation a reductive elimination process occurring from reaction cyclometalated Au
Two new 'hybrid' metallodrugs of Au(III) (AuTAML) and Cu(II) (CuTAML) were designed featuring a tamoxifen-derived pharmacophore to ideally synergize the anticancer activity both metal center organic ligand. The compounds have antiproliferative effects against human MCF-7 MDA-MB 231 breast cancer cells. Molecular dynamics studies suggest that retain binding estrogen receptor (ERα). In vitro in silico showed derivative is an inhibitor seleno-enzyme thioredoxin reductase, while complex may act...
Abstract Aquaporin‐3 (AQP3) is a membrane channel with dual aquaglyceroporin/peroxiporin activity, facilitating the diffusion of water, glycerol and H 2 O across cell membranes. AQP3 shows aberrant expression in melanoma its role adhesion, migration proliferation well described. Gold compounds were shown to modulate activity reduced associated toxicity, making them promising molecules for cancer therapy. In this study, we validated phenotype resulting from AQP3‐silencing two lines, MNT‐1...
Brain degenerative disorders such as Alzheimer's disease (AD) can be exacerbated by aberrant metabolism. Supplementation with probiotic bacteria is emerging a promising preventative strategy for both neurodegeneration and metabolic syndrome. In this study, we assess the impact of Lab4b consortium on (i) cognitive pathological markers AD progression (ii) status in 3xTg-AD mice subjected to challenge high fat diet. The group receiving performed better novel object recognition test displayed...
Abstract Perovskite oxides are receiving wide interest for photocatalytic and photoelectrochemical devices, owing to their suitable band gaps solar light absorption stability in aqueous applications. Herein, we assess the activity of PrFeO 3 photocathodes prepared by using spray pyrolysis calcination temperatures between 500 700 °C. Scanning electron microscopy shows corrugated films high surface coverage on conductive glass substrate. The electrochemically active area slight decreases with...
N-heterocyclic carbenes (NHCs) have become attractive ligands for functionalizing gold nanoparticle surfaces with applications ranging from catalysis to biomedicine. Despite their great potential, NHC stabilized colloids (NHC@AuNPs) are still scarcely explored and further efforts should be conducted improve design functionalization. Here, the 'bottom-up' synthesis of two water-soluble nanoparticles (AuNP-1 AuNP-2) by hydrophilic mono- bidentate is reported together characterization various...
Aging and metabolic syndrome are associated with neurodegenerative pathologies including Alzheimer's disease (AD) there is growing interest in the prophylactic potential of probiotic bacteria this area. In study, we assessed neuroprotective Lab4P consortium both age metabolically challenged 3xTg-AD mice human SH-SY5Y cell culture models neurodegeneration. mice, supplementation prevented disease-associated deteriorations novel object recognition, hippocampal neurone spine density...
With the aim to design water-soluble organometallic Ru(II) complexes acting as anticancer agents catalyzing transfer hydrogenation (TH) reactions with biomolecules, we have synthesized four monocarbonyl (1–4), featuring 1,4-bis(diphenylphosphino)butane (dppb) ligand and different bidentate nitrogen (N∧N) ligands, of general formula [Ru(OAc)CO(dppb)(N∧N)]n (n = +1, 0; OAc acetate). The compounds been characterized by methods, including 1H 31P NMR spectroscopies, electrochemistry, well...
Following our recent reports on the inhibition of water and glycerol channel aquaglyceroporin-3 (AQP3) by coordination complex [AuIII(1,10-phenanthroline)Cl2] (Auphen), a series six new Au(III) complexes featuring substituted 1,10-phenanthroline ligands (1–6) have been synthesized characterized. The speciation compounds studied in buffered solution UV–visible spectrophotometry showed that most remain stable for several hours. Quantum mechanics (QM) studies hydrolysis processes suggest they...
Abstract To gain more insight into the factors controlling efficient cysteine arylation by cyclometallated Au III complexes, reaction between selected gold compounds and different peptides was investigated high‐resolution liquid chromatography electrospray ionization mass spectrometry (HR‐LC‐ESI‐MS). The deduced mechanisms of C−S cross‐coupling, also supported density functional theory (DFT) quantum mechanics/molecular mechanics (QM/MM) calculations, evidenced key role secondary peptidic...
The application of Au(I) ions in pharmaceuticals, including nuclear medicine, is limited by their instability towards reduction vivo. gold radionuclide 198Au with a half-life 2.7 days emits gamma radiation ideal for diagnostic purposes and also generates β- particles suitable effective cancer radiotherapy, making it perfect nuclide ‘theranostics’. Here, we explore N-heterocyclic carbene (NHC) organometallic chemistry to stabilize 198Au(I) radiopharmaceuticals. Thus, different NHC compounds...
Gold(III) organometallic complexes, particularly cyclometalated Au(III) compounds, have emerged as powerful tools in catalysis and bioinorganic chemistry, offering unique reactivity distinct from their Au(I) counterparts. Among most interesting transformations, C–S cross‐coupling reactions become a selective strategy for cysteine arylation, enabling site‐specific modifications of peptides proteins. This review provides comprehensive overview complexes bond formation, detailing the...
A graft-to-strategy to tether alkyne-terminated polyesters the surface of dopazide stabilised AuNPs via click chemistry in aqueous conditions situ .
Abstract With the aim of exploiting new organometallic species for cross‐coupling reactions, we report here on Au III ‐mediated C aryl −P bond formation occurring upon reaction C^N cyclometalated complexes with phosphines. The [Au(C^N)Cl 2 ] complex 1 featuring bidentate 2‐benzoylpyridine (C CO N) scaffold was found to react PTA (1,3,5‐triaza‐7‐phosphaadamantane) under mild conditions, including in water, afford corresponding phosphonium 5 through C−P reductive elimination. A mechanism is...
Within the framework of designing new self-assembled metallosupramolecular architectures for drug delivery, seven [Pd2L4]4+ metallacages (L = 2,6-bis(pyridine-3-ylethynyl)pyridine) featuring different groups in exo-position, selected to enhance cage solubility aqueous environment, were synthesized. Thus, carboxylic acids, sugars, and PEG tethered bispyridyl ligands directly or via disulfide bond formation, as well click chemistry. The respective cages characterized by methods, including NMR...
This review is aimed at providing a concise overview of the results obtained by our group in field organometallic chemistry gold. Therefore, selection examples amongst most extensively explored families bioactive gold complexes — Au(I) N-heterocyclic carbenes and cyclometalated Au(III) compounds presented. Insights into bio-inorganic mechanisms reactivity organogold an integrated investigational approach, knowledge structure-activity relationships are discussed also relation to novel...
The most recurrent familial cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the presence an abnormal number intronic GGGGCC (G4C2) repetitions in C9orf72 gene, which has been proposed to drive ALS/FTD pathogenesis. Recently, it shown that such G4C2 can fold into G-quadruplex (G4) secondary structures. These G4s have selectively stabilized by small-molecule binders, furnishing proof principle targeting these non-canonical nucleic acid sequences represents a...
The therapeutic management of melanoma, the most aggressive form skin cancer, remains challenging. In search for more effective options, metal-based complexes are being investigated their anticancer properties. Cisplatin was first clinically approved plati-num-based drug and, based on its success, other metals (e.g. gold) used to design novel compounds. present work, antimelanoma potential a new organometallic cy-clometalated Au(III) complex [[Au(CNOxN)Cl2] (CNOxN =...
Background/Objectives: The therapeutic management of melanoma, the most aggressive form skin cancer, remains challenging. In search for more effective options, metal-based complexes are being investigated their anticancer properties. Cisplatin was first clinically approved platinum-based drug and, based on its success, other metals (e.g., gold) used to design novel compounds. Methods: antimelanoma potential a new organometallic cyclometalated Au(III) complex [[Au(CNOxN)Cl2] (CNOxN =...
In recent years, the reactivity of gold complexes was shown to extend well beyond π-activation and hold promises achieve selective cross-couplings in several C-C C-E (E=heteroatom) bond forming reactions. Here, with aim exploiting new organometallic species for cross-coupling reactions, we report on Au(III)-mediated C(sp2 )-C(sp) occurring upon reaction cyclometalated complex [Au(CCH2 N)Cl2 ] (1, CCH2 N=2-benzylpyridine) AgPhCC. The progress has been monitored by NMR spectroscopy,...