A5044737738- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Transportation Safety and Impact Analysis
- Engineering Applied Research
- Nuclear and radioactivity studies
- Catalytic Processes in Materials Science
- Luminescence and Fluorescent Materials
- Automotive and Human Injury Biomechanics
- Nanocluster Synthesis and Applications
- Organic Light-Emitting Diodes Research
- Industrial Technology and Control Systems
- Nanomaterials for catalytic reactions
- Prostate Cancer Treatment and Research
- Agriculture and Farm Safety
- Supramolecular Self-Assembly in Materials
- Peptidase Inhibition and Analysis
- Photoacoustic and Ultrasonic Imaging
- Chemical Synthesis and Analysis
- nanoparticles nucleation surface interactions
- Click Chemistry and Applications
- Photopolymerization techniques and applications
- Engineering and Material Science Research
- CO2 Reduction Techniques and Catalysts
- Industrial Engineering and Technologies
- Metal complexes synthesis and properties
Massachusetts Institute of Technology
2021-2025
University of British Columbia
2015-2021
Griffith University
2021
Johnson Matthey (United Kingdom)
2012-2021
Vancouver Biotech (Canada)
2015-2020
Almac (United Kingdom)
2018
Children's Hospital of Philadelphia
2018
University of California, San Francisco
2010-2016
Johnson Matthey (Germany)
2012-2014
Princeton University
2013
Abstract TMPRSS2 is an androgen-regulated cell-surface serine protease expressed predominantly in prostate epithelium. highly localized high-grade cancers and the majority of human cancer metastases. Through generation mouse models with a targeted deletion Tmprss2, we demonstrate that activity this regulates cell invasion metastasis to distant organs. By screening combinatorial peptide libraries, identified spectrum substrates include pro-hepatocyte growth factor (HGF). HGF activated by...
We report here the benefits of using a palladium membrane reactor to drive hydrogenation chemistry with electricity while bypassing formation gaseous H2. This technique uses physically separate electrochemical and chemistry. As result, can be performed electrochemically protons but in any organic solvent. In this article, we outline series experiments showing how proceeds at faster reaction rates much higher voltage efficiency than an electrode. Moreover, solvents without contamination by...
Convenient strategies for the deconstruction and reprocessing of thermosets could improve circularity these materials, but most approaches developed to date do not involve established, high-performance engineering materials. Here, we show that bifunctional silyl ether, i.e., R'O-SiR2-OR'', (BSE)-based comonomers generate covalent adaptable network analogues industrial thermoset polydicyclopentadiene (pDCPD) through a novel BSE exchange process facilitated by low-cost food-safe catalyst...
Imidazoquinolines (IMDs), such as resiquimod (R848), are of great interest potential cancer immunotherapies because their ability to activate Toll-like receptor 7 (TLR7) and/or TLR8 on innate immune cells. Nevertheless, intravenous administration IMDs causes severe immune-related toxicities, and attempts improve tissue-selective exposure while minimizing acute systemic inflammation have proven difficult. Here, using a library R848 "bottlebrush prodrugs" (BPDs) that differ only by release...
Abstract Supramolecular polymer networks contain non-covalent cross-links that enable access to broadly tunable mechanical properties and stimuli-responsive behaviors; the incorporation of multiple unique within such materials further expands their responses functionality. To date, however, design has been accomplished through discrete combinations distinct interaction types in series, limiting logic. Here we introduce concept leveraging “nested” supramolecular crosslinks, wherein two...
The synthesis and characterisation of a series new gold- palladium-containing symmetrical imidazolium salts are described which display significant cation-dependent effects determined by the structure alkyl chains motifs. Whereas direct reduction Pd can produce stable nanoparticles (NPs) coated salts, addition strong base to or Au before gives NPs, potentially pacified N-heterocyclic carbene units. possibility NP surface protection metal-carbon bonds in these systems is investigated...
Identifying the ripening modes of supported metal nanoparticles used in heterogeneous catalysis can provide important insights into mechanisms that lead to sintering. We report observation a crossover from Smoluchowski Ostwald ripening, under realistic reaction conditions, for monomodal populations precisely defined gold particles nanometer size range, as function decreasing particle size. study effects CO oxidation on distributions and atomic structures mass-selected Au(561±13), Au(923±20)...
Abstract The deposition of preformed nanocluster beams onto suitable supports represents a new paradigm for the precise preparation heterogeneous catalysts. performance materials must be validated in model catalytic reactions. It is shown that gold/copper (Au/Cu) nanoalloy clusters (nanoparticles) variable composition, created by sputtering and gas phase condensation before magnesium oxide powders, are highly active reduction 4‐nitrophenol solution at room temperature. Au/Cu bimetallic offer...
Mesoionic carbenes have found wide use as components of homogeneous catalysts. Recent discoveries have, however, shown that metal complexes such ligands also huge potential in photochemical research and the activation small molecules. We present here three ReI with mesoionic pyridyl-carbene ligands. The display reduction steps which were investigated via UV–vis–NIR–IR spectro-electrochemistry, these results point toward an EC mechanism. compounds emit visible range solution at room...
The immobilization of homogeneous catalysts onto supports to improve recyclability while maintaining catalytic efficiency is often a trial-and-error process limited by poor control the local catalyst environment and few strategies append support materials. Here, we introduce modular heterogenous catalysis platform that addresses these challenges. Our approach leverages well-defined interiors self-assembled Pd12L24 metal–organic cages/polyhedra (MOCs): simple mixing catalyst-ligand choice...
Copper(I) complexes (Cu-DPSO and Cu-Me-DPSO) utilizing sulfoxide-bridged dipyridyl ligands are reported. Cu-DPSO demonstrates photophysical properties typical with [Cu(disphosphine)(diimine)]+ complexes, however additional steric bulk in the 6- 6′-positions of diimine ligand to give complex Cu-Me-DPSO; photophysics greatly altered. This species is isolated as an amorphous powder (a-Cu-Me-DPSO) which emits yellow light; upon heating 180 °C, a crystalline formed (c-Cu-Me-DPSO) shows large...
We report label-free electrical detection of enzymatic reactions using 2-D nanofluidic channels and investigate reaction kinetics on immobilized substrates in nanoscale-confined spaces. Trypsin proteolysis is chosen for demonstration the scheme. When trypsin cleaves poly-l-lysine coated surface silica nanochannels, resulting change charge density can be detected by monitoring ionic conductance nanochannels. Our results show that such faster than binding nanochannels low-concentration...
Sulfur lone pairs in bridged dimers enhance intersystem crossing and phosphorescence through orbital mixing electrostatic screening.
The generation of beams atomic clusters in the gas phase and their subsequent deposition (in vacuum) onto suitable catalyst supports, possibly after an intermediate mass filtering step, represents a new attractive approach for preparation model particles. Compared with colloidal route to production pre-formed catalytic nanoparticles, nanocluster beam offers several advantages: produced have no ligands, size can be selected arbitrarily high precision by filter, metal particles containing...
Copper(I) complexes are seen as more sustainable alternatives to those containing metal ions such iridium and platinum for emitting devices. have the ability radiatively decay via a thermally activated delayed fluorescence (TADF) pathway, leading higher photoluminescent quantum yields. In this work we discuss six new heteroleptic Cu(I) of diphosphine-diimine motif. The diphosphine ligands employed (oxidi-2,1-phenylene)bis(diphenylphosphine) (DPEPhos), diimine fragments sulfur-bridged...
Abstract To gain more insight into the factors controlling efficient cysteine arylation by cyclometallated Au III complexes, reaction between selected gold compounds and different peptides was investigated high‐resolution liquid chromatography electrospray ionization mass spectrometry (HR‐LC‐ESI‐MS). The deduced mechanisms of C−S cross‐coupling, also supported density functional theory (DFT) quantum mechanics/molecular mechanics (QM/MM) calculations, evidenced key role secondary peptidic...
Permanently cross-linked polymer networks-thermosets-are often difficult to chemically deconstruct. The installation of cleavable bonds into the strands thermosets using comonomers as additives can facilitate thermoset deconstruction without replacement permanent cross-links, but such monomers lead reduced thermomechanical properties and require high loadings function effectively, motivating design new optimal additives. Here, we introduce "strand-fusing cross-linkers" (SFCs), which fuse two...
Abstract Permanently cross‐linked polymer networks—thermosets—are often difficult to chemically deconstruct. The installation of cleavable bonds into the strands thermosets using comonomers as additives can facilitate thermoset deconstruction without replacement permanent cross‐links, but such monomers lead reduced thermomechanical properties and require high loadings function effectively, motivating design new optimal additives. Here, we introduce “strand‐fusing cross‐linkers” (SFCs), which...
Well-defined nanoparticles show promise as model catalysts in the quest for new/improved practical with tunable chemical properties. Here we demonstrate production, performance, and stability of a new class catalyst systems, consisting size-selected (PdN) nanoclusters supported on (graphite) powders suitable realistic, test tube reaction conditions. The were synthesized by cluster beam deposition onto planar surface followed microdicing. Cluster size-dependent (N = 55 to 400) catalytic...
Cutaneous autonomic function can be quantified by the assessment of sudomotor and vasomotor responses. Although piloerector muscles are innervated sympathetic nervous system, there at present no methods to quantify pilomotor function.To piloerection using phenylephrine hydrochloride in humans.Pilot study.Hospital-based study.Twenty-two healthy volunteers (18 males,4 females) aged 24 48 years participated 6 studies.Piloerection was stimulated iontophoresis 1% phenylephrine. Silicone...
A C-pyrenyl poly(methylenephosphine) (Mn = 4800, Đ 1.56) was synthesized from the anionic polymerization of a P-mesityl phosphaalkene. The phosphine oxide polymer exhibits blue fluorescence in solution (λmax 379, 400 nm, λonset 560 nm; Φ 0.05) and blue-green solid state at room temperature 460 0.07). In contrast, unoxidized displays only weak emission no state. Fluorescence studies partially oxidized polymers (50, 75, 83% oxidation) indicate that "turn on" occurs very high degrees oxidation...