A5024337874- PI3K/AKT/mTOR signaling in cancer
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Lymphoma Diagnosis and Treatment
- PARP inhibition in cancer therapy
- Thyroid Disorders and Treatments
- Cancer therapeutics and mechanisms
- Chronic Lymphocytic Leukemia Research
- Infectious Diseases and Mycology
- Mast cells and histamine
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Hops Chemistry and Applications
- DNA Repair Mechanisms
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Respiratory Support and Mechanisms
- Ubiquitin and proteasome pathways
- Electrostatic Discharge in Electronics
- Renal cell carcinoma treatment
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Fungal Plant Pathogen Control
- Chemokine receptors and signaling
Campbell University
2022-2023
Southeastern Health
2022-2023
Tata Memorial Hospital
2019
Vanderbilt University
2009-2015
Bipar
2008-2009
Vanderbilt University Medical Center
2008
Harvard University
2008
Indiana University School of Medicine
2005
Indiana University
2005
Notch plays critical roles in both cell fate decisions and tumorigenesis. receptor engagement initiates signaling cascades that include a phosphatidylinositol 3-kinase/target of rapamycin (TOR) pathway. Mammalian TOR (mTOR) participates two distinct biochemical complexes, mTORC1 mTORC2, the relationship between mTORC2 physiological outcomes dependent on is unknown. In this study, we report contributions to thymic T-cell acute lymphoblastic leukemia (T-ALL) driven by Notch. Conditional...
While 30%–70% of RSV-infected infants develop bronchiolitis, 2% require hospitalization. It is not clear why disease severity differs among healthy, full-term infants; however, virus titers, inflammation, and Th2 bias are proposed explanations. TLR4 associated with these phenotypes, the role this receptor in respiratory syncytial (RSV) pathogenesis controversial. Here, we evaluated interaction between environmental factors RSV defined immune mediators severe illness. Two independent...
T helper type 1 (Th1) and Th2 cells have critical roles in the development of cell-mediated humoral immune responses, respectively. This division function predicts that Th1 mediate inflammatory diseases promote antibody (Ab)-mediated autoimmunity. Our previous studies using HEK-293 expressing extracellular domain TSH receptor (TSHR) showed Stat4-/- mice, which lack cells, are susceptible, whereas Stat6-/- resistant to induction Graves' hyperthyroidism. To investigate role Stat4 Stat6 genes...
Differentiation of T helper (Th) subset 2 effector lymphocytes is thought to foreclose on IFN-gamma gene expression. Using an IL-4 locus modified detect transcriptional induction this cytokine in developing Th2 cells, we show here that these cells contributed effectively a long-term memory population. A CD4 formed efficiently from activated population after the and differentiation into IL-4-producing with characteristics. Memory derived activation remained committed competence genes when...
Monoclonal gammopathy of renal significance (MGRS) is a rare heterogeneous group kidney disorders that encompasses all caused by deposition monoclonal protein (M-protein) and its light or heavy chain fragments secreted pre-malignant non-malignant B-cell clones in patients who do not meet the diagnostic criteria for multiple myeloma (MM) other malignancies. MGRS can manifest as glomerular diseases, tubulopathies, vascular involvement with varying clinical presentations, making diagnosis...
Hodgkin lymphoma (HL) survivors have an increased risk of developing subsequent treatment-related primary malignancies. In the last few decades, advances in knowledge, radiotherapy, chemotherapy and autologous stem cell transplantation led to transformation lethal malignancy into highly curable malignancy, thereby improving outcomes. With prolonged survival, late adverse effects, such as malignancies, steadily increases over time. Herein, we present first case a second stage IV peripheral...
Renal cell carcinoma (RCC) is the most aggressive urological malignancy, with a high recurrence rate. Despite rapid evolution of treatment RCC from non-specific cytotoxic therapies to specific novel combination therapies, general prognosis for advanced remains poor because patients' responses these vary. Herein, we present case male in early forties who was diagnosed right lower pole renal mass level IV tumour thrombus, which later confirmed as stage IIIc clear RCC. About 19 months after...
Abstract Mammalian target of rapamycin (mTOR) is an important component the PI3-kinase (PI3K) pathway that regulates cell growth and proliferation. PI3K signaling cascades can be initiated by activation Notch, a critical regulator for T lineage commitment leukemia development. Here we show mTOR complex 2 (mTORC2) functionally vital as downstream Notch in thymocytes T-cell acute lymphoblastic (T-ALL). Conditional deletion rictor, essential mTORC2, results impaired proliferation...
Abstract Mammalian target of rapamycin (mTOR) is involved in cellular processes such as survival and proliferation. Regulation the original rapamycin-sensitive complex, mTORC1, signaling downstream from Akt well defined. However, physiological roles lymphoid cells an alternative mTOR mTORC2, are unknown. Using conditional deletion rictor, essential subunit we recently uncovered a rate-limiting role mTORC2 T cell development activation. We now show that regulates helper function by pathway...
PDK1 and its downstream target Akt contribute both to pre‐TCR TCR signal transduction important for proliferation survival of thymocytes undergoing β‐selection or mature T cells. Mammalian rapamycin (mTOR) controls various cell functions is a immunosuppressant drugs. Recent biochemical studies suggest that mTOR complex 2 (mTORC2) may be the exclusive kinase phosphorylation S473 in Akt. However, role mTORC2 lineage not known. Here, we show regulates development cytokine‐induced proliferation....
Poly‐(ADP‐Ribose) Polymerases (PARPs) catalyze formation of branched ADP‐ribose polymers by transfer residues from NAD+ to target protein. PARPs are involved in a wide range biological processes including inflammation, regulation gene expression, and DNA damage repair. Although there 17 PARP superfamily members, very little is known about their function except that PARP‐1. PARP‐14, member macrodomain‐containing subfamily, highly expressed lymphoid organs interacts with the IL‐4‐activated...
Follicular lymphoma (FL) is a mature B-cell that can transform into more aggressive disease such as diffuse large lymphoma, Burkitt or precursor B-lymphoblastic leukaemia/lymphoma. The process of transformation FL occurs by the acquisition additional genetic alterations, e.g. c-MYC rearrangement, TP53, and cyclin D1 inactivation. Herein, we describe four cases transformed non-Hodgkin lymphomas within six months their initial diagnosis. Subsequent testing c-myc, P53 immunohistochemistry...