A5012881493- Global Maternal and Child Health
- Maternal and Perinatal Health Interventions
- Health Systems, Economic Evaluations, Quality of Life
- Trypanosoma species research and implications
- Global Public Health Policies and Epidemiology
- Maternal and fetal healthcare
- Smoking Behavior and Cessation
- Birth, Development, and Health
- Maternal and Neonatal Healthcare
- Breastfeeding Practices and Influences
- Neonatal Respiratory Health Research
- Health and Lifestyle Studies
- Pregnancy and preeclampsia studies
- Colorectal Cancer Screening and Detection
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Child Nutrition and Water Access
- Mosquito-borne diseases and control
- Economic and Environmental Valuation
- SARS-CoV-2 and COVID-19 Research
- Blood Pressure and Hypertension Studies
- Global Cancer Incidence and Screening
- Emergency and Acute Care Studies
- Healthcare Policy and Management
- Research on Leishmaniasis Studies
Instituto de Efectividad Clínica y Sanitaria
2015-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2016-2024
CARE USA
2022
Neurobehavioral Systems
2019
University of Washington
2019
UNC Lineberger Comprehensive Cancer Center
2016
Experimental Medicine and Biology Institute
2016
National Cancer Institute
2016
Center for Cancer Research
2016
University of California, San Diego
2016
Therapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered hospitalized patients has been unsuccessful, perhaps because antibodies should be earlier in course illness.We conducted a randomized, double-blind, placebo-controlled trial with high IgG titers against severe acute respiratory syndrome 2 (SARS-CoV-2) older adult within 72 hours after onset mild Covid-19 symptoms. The primary end point was disease,...
Cesarean section rates show a wide variation among countries in the world, ranging from 0.4 to 40 percent, and continuous rise trend has been observed past 30 years. Our aim was explore association of cesarean different with their maternal neonatal mortality test hypothesis that low-income countries, increasing were associated reductions both outcomes, whereas high-income such did not exist.We performed cross-sectional multigroup ecological study using data 119 1991 2003. These classified...
Adolescent girls between 15 and 19 years give birth to around 16 million babies each year, 11% of births worldwide. We sought determine whether adolescent mothers are at higher risk maternal perinatal adverse outcomes compared with aged 20–24 in a prospective, population-based observational study newborn low resource settings. undertook multi-country research all pregnant women defined geographic areas across 7 sites six low-middle income countries (Kenya, Zambia, India, Pakistan, Guatemala...
<h3>Importance</h3> Despite extensive knowledge of hypertension treatment, the prevalence uncontrolled is high and increasing in low- middle-income countries. <h3>Objective</h3> To test whether a community health worker–led multicomponent intervention would improve blood pressure (BP) control among low-income patients with hypertension. <h3>Design, Setting, Participants</h3> A cluster randomized trial was conducted 18 centers for primary care within national public system providing free...
There are many systematic reviews of continuing education programmes and educational strategies for quality improvement in health care. Most the reviewed studies one-off evaluations rather than impact with long-term follow-up. few organisational, financial regulatory interventions, high-quality studies. These interventions probably as or more important strategies, although they less well evaluated. Few have been undertaken low- middle-income countries (LMIC) that address maternal child...
Mobile health (mHealth) is emerging as a useful tool to improve healthcare access especially in the developing world, where limited services linked poor antenatal care, and maternal perinatal mortality. The objective of this study 1) understand pregnant women's usage cell phones 2) survey information needs interests population attending public hospitals centers two cities Argentina. This not available it basis develop strategy for improving care via phones. Questionnaires were verbally...
While 30%–70% of RSV-infected infants develop bronchiolitis, 2% require hospitalization. It is not clear why disease severity differs among healthy, full-term infants; however, virus titers, inflammation, and Th2 bias are proposed explanations. TLR4 associated with these phenotypes, the role this receptor in respiratory syncytial (RSV) pathogenesis controversial. Here, we evaluated interaction between environmental factors RSV defined immune mediators severe illness. Two independent...
ObjectivesThe development of measures such as the EQ-HWB (EQ Health and Wellbeing) requires selection items. This study explored psychometric performance candidate items, testing their validity in patients, social carer users, carers.MethodsArticle online surveys that included items (N = 64) were conducted Argentina, Australia, China, Germany, United Kingdom, States. Psychometric assessment on missing data, response distributions, known group differences was undertaken. Dimensionality using...
Abstract Cesarean section rates worldwide are rising, driven by medically unnecessary cesarean use. The new World Health Organization Labour Care Guide (LCG) aims to improve the quality of care for women during labor and childbirth. Using LCG might reduce overuse cesarean; however, its effects have not been evaluated in randomized trials. We conducted a stepped-wedge, cluster-randomized pilot trial four hospitals India evaluate implementation an strategy intervention, compared with routine...
Cardiovascular disease (CVD) is the primary cause of mortality and morbidity in Argentina representing 34.2% deaths 12.6% potential years life lost (PYLL). The aim study was to estimate burden acute coronary heart (CHD) stroke cost-effectiveness preventative population-based clinical interventions. An epidemiological model built incorporating prevalence distribution high blood pressure, cholesterol, hyperglycemia, overweight obesity, smoking, physical inactivity, obtained from Argentine...
Rates of caesarean section have steadily increased in most middle- and high-income countries over the last few decades without medical justification. Maternal request is one frequently cited non-medical factors contributing to this trend. The objectives study were assess pregnant women's preferences regarding mode delivery compare actual rates public private sectors. A prospective cohort was conducted two three hospitals Buenos Aires, Argentina. 382 nulliparous women (183 from sector 199...
Compared with South America, there is a lack of epidemiologic studies about the risk congenital transmission Trypanosoma cruzi in Central America and Mexico. It has been suggested that T. genotypes might differ by region vary according to parasite's genotype. Our objective was compare rates three countries. We performed an observational prospective study 2011-2014 enrolling women at delivery one hospital Argentina, two hospitals Honduras, Congenital infection defined as presence or more...
Background: Compelling evidence shows that progestins regulate breast cancer growth. Using preclinical models, we demonstrated antiprogestins are inhibitory when the level of progesterone receptor isoform A (PR-A) is higher than B (PR-B) and they might stimulate growth PR-B predominant. The aims this study were to investigate ex vivo responses mifepristone (MFP) in carcinomas with different PR ratios examine their clinical molecular characteristics. Methods: We performed human tissue culture...
To examine the prevalence of novel newborn types among 165 million live births in 23 countries from 2000 to 2021.Population-based, multi-country analysis.National data systems middle- and high-income countries.Liveborn infants.Country teams with high-quality were invited be part Vulnerable Newborn Measurement Collaboration. We classified by six based on gestational age information (preterm <37 weeks versus term ≥37 weeks) size for defined as small (SGA, <10th centile), appropriate (10th-90th...
To examine the association between maternal pre-pregnancy weight status and risk of stillbirth, pre-eclampsia preterm delivery.Hospital-based cohort study using prospectively recorded data.Ten public hospitals in Buenos Aires, Argentina.46,964 pregnant women who had a delivery during 2003-2006.Prepregnancy body mass index (BMI) was used to categorize four categories from underweight obese. The reference group were with BMI 18.5 24.9. Crude adjusted odds ratios calculated multiple logistic...
We conducted a cross-sectional study of Chagas disease in five endemic areas Argentina, Bolivia, Honduras, and México to estimate the prevalence Trypanosoma cruzi-specific antibodies pregnant women, assess use rapid test (Chagas Stat-Pak) screen for T. cruzi infection at time delivery. The measured by enzyme-linked immunosorbent assay (ELISA) maternal blood was 5.5% (a range 0.8-28.8% among countries) 2,495 women enrolled. Compared with ELISA samples, Stat-Pak sensitivity specificity...