A5000117746- Lipoproteins and Cardiovascular Health
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer, Lipids, and Metabolism
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Semiconductor Quantum Structures and Devices
- VLSI and Analog Circuit Testing
- Atherosclerosis and Cardiovascular Diseases
- Engineering Applied Research
- Refrigeration and Air Conditioning Technologies
- Lung Cancer Diagnosis and Treatment
- Nutrition and Health in Aging
- Semiconductor Lasers and Optical Devices
- Eicosanoids and Hypertension Pharmacology
- Medical Imaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Diabetes Treatment and Management
- Cardiac Structural Anomalies and Repair
- Aerodynamics and Fluid Dynamics Research
- Hydraulic and Pneumatic Systems
Juntendo University
2016-2025
Nippon Dental University
2004-2024
Shibuya University Network
2017-2023
Brigham and Women's Hospital
2012-2021
Harvard University
2014-2021
Nagoya Medical Center
2010-2020
Nagoya City University
1992-2020
National Institute of Technology, Nara College
2020
Nagoya Ekisaikai Hospital
1994-2020
Juntendo University Hospital
2018-2020
Abstract Despite the global impact of macrophage activation in vascular disease, underlying mechanisms remain obscure. Here we show, with proteomic analysis cell lines treated either IFNγ or IL-4, that PARP9 and PARP14 regulate activation. In primary macrophages, have opposing roles silencing induces pro-inflammatory genes STAT1 phosphorylation M(IFNγ) cells, whereas it suppresses anti-inflammatory gene expression STAT6 M(IL-4) cells. ADP-ribosylation STAT1, which is suppressed by PARP9....
Vascular calcification is a common feature of major cardiovascular diseases. Extracellular vesicles participate in the formation microcalcifications that are implicated atherosclerotic plaque rupture; however, mechanisms regulate calcifying extracellular remain obscure. Here, we have demonstrated sortilin key regulator smooth muscle cell (SMC) via its recruitment to vesicles. Sortilin localized vessels human and mouse atheromata participated SMC culture. regulated loading protein tissue...
Current guidelines call for high-intensity statin therapy in patients with cardiovascular disease on the basis of several previous "more versus less statins" trials. However, no clear evidence more statins has been established an Asian population. In this prospective, multicenter, randomized, open-label, blinded end point study, 13 054 Japanese stable coronary artery who achieved low-density lipoprotein cholesterol (LDL-C) <120 mg/dL during a run-in period (pitavastatin 1 mg/d) were...
Chronic kidney disease (CKD) increases cardiovascular risk. Underlying mechanisms, however, remain obscure. The uremic toxin indoxyl sulfate is an independent risk factor in CKD. We explored the potential impact of on proinflammatory activation macrophages and its underlying mechanisms.We examined vitro effects clinically relevant concentrations responses roles organic anion transporters transporting polypeptides (OATPs). A systems approach, involving unbiased global proteomics,...
BACKGROUND: Low plasma levels of eicosapentaenoic acid (EPA) are associated with cardiovascular events. This trial aimed to assess the clinical benefits icosapent ethyl in patients coronary artery disease, a low EPA/arachidonic (AA) ratio, and statin treatment. METHODS: In this prospective, multicenter, randomized, open-label, blinded end-point study, stable disease EPA/AA ratio (<0.4) were randomized EPA (1800 administered daily) or control group. The primary end point was composite...
To identify the amyloid β peptide (Aβ) 1–42-degrading enzyme whose activity is inhibited by thiorphan and phosphoramidon in vivo, we searched for neprilysin (NEP) homologues cloned neprilysin-likepeptidase (NEPLP) α, NEPLP β, γ cDNAs. We expressed NEP, phosphate-regulating gene with homologies to endopeptidases on X chromosome (PEX), NEPLPs, damage-induced neuronal endopeptidase (DINE) 293 cells as 95- 125-kDa proteins found that enzymatic activities of PEX, well those NEP DINE, were...
The aim was to evaluate the clinical outcome of hypofractionated stereotactic radiotherapy (SRT) with CyberKnife for nonfunctioning pituitary adenoma. From October 2000 March 2009, 100 patients adenoma were treated SRT. Forty-three male, and 57 female. patient's ages ranged from 16 82 years (median, 59 years). Five medically inoperable, 1 refused surgery; remaining 94 recurrent cases or those receiving postoperative adjuvant No had a history previous cranial radiotherapy. Tumor volume 0.7...
It has been proposed that bone marrow-derived cells infiltrate the neointima, where they differentiate into smooth muscle (SM) cells; however, technical limitations have hindered clear identification of lineages "SM cell-like" cells.Using a specific antibody against definitive SM cell lineage marker myosin heavy chain (SM-MHC) and mouse lines in which reporter genes were driven by regulatory programs for either SM-MHC or α-actin, we demonstrated although some express α-actin wire...
Abstract Historically, human diseases have been differentiated and categorized based on the organ system in which they primarily manifest. Recently, an alternative view is emerging that emphasizes different often common underlying mechanisms shared intermediate pathophenotypes, or endo(pheno)types . Within this framework, a specific disease’s expression consequence of interplay between relevant endophenotypes their local, organ-based environment. Important examples such are inflammation,...
By both numerical simulation and experimental investigation, we found it possible to enlarge the grain size (∼3000 Å) of polycrystalline silicon (poly-Si) films by excimer laser annealing, using a new method control solidification process molten Si - low-temperature (≦400°C) substrate heating during annealing. Poly-Si thin-film transistors (TFTs) fabricated this annealing showed high field-effect mobility 230 cm 2 /V·s, good uniformity (±10%) within effective irradiation area.
Omega-3 polyunsaturated fatty acids (PUFAs) have been a hot topic since the Japan EPA Lipid Intervention Study (JELIS), first landmark study using highly purified eicosapentaenoic acid (EPA), indicated that could decrease incidence of cardiovascular events. Over 20 years passed JELIS was conducted, and standard treatment for dyslipidemia has altered significantly then. The subjects did not undertake current risk management especially statins exclusively target secondary prevention patients....
Adrenomedullin (AM) is a novel vasodilating peptide involved in the regulation of circulatory homeostasis and implicated pathophysiology cardiovascular disease. We tested hypothesis that AM also possesses angiogenic properties. Using laser Doppler perfusion imaging, we found stimulated recovery blood flow to affected limb mouse hind-limb ischemia model. exerted this effect part by promoting expression vascular endothelial growth factor (VEGF) ischemic limb, immunostaining for CD31 showed...
Adrenomedullin (AM) is a novel vasodilating peptide thought to have important effects on cardiovascular function. The aim of this study was assess the activity endogenous AM in system using knockout mice.Mice heterozygous for an AM-null mutation (AM+/-) and their wild-type littermates were subjected aortic constriction or angiotensin II (Ang II) infusion. resultant stress led increases heart weight/body weight ratios, left ventricular wall thickness, perivascular fibrosis, as well expression...
Modulation of smooth muscle cell (SMC) phenotype plays a central role in neointima formation. We recently demonstrated that Am80, synthetic retinoic acid receptor alpha-specific agonist, inhibits the activity transcription factor KLF5, which is essential for formation after vascular injury. In present study, we aimed to further analyze mechanism by Am80 KLF5 and effects inhibiting on SMCs lesion formation, as well evaluate potential use prevention in-stent found inhibited both expression...
The aim of this study was to survey the 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) cancer screening program conducted in Japan.The "FDG-PET program" included both FDG-PET and positron with computed (PET/CT) or without other combined tests that were performed for asymptomatic subjects. A total 155,456 subjects who underwent during 2006-2009 analyzed.Of subjects, positive findings suggesting possible noted 16,955 (10.9 %). number cases detected 1,912 (1.23 % screened cases,...
Immunoglobulin G4 (IgG4)-related systemic disease was first recognized as a clinicopathological entity about 10 years ago, and since then, it has attracted growing attention. It is an autoimmune which affects multiple organs including the pancreas, bile duct, salivary glands retroperitoneum. Further, recently reported that can be manifested periarteritis, often inflammatory abdominal aortic aneurysm. We describe case of 75-year-old man with pancreatitis parotitis who presented angina. The...
Abstract Background The nutritional status and frailty are crucial in patients with aortic stenosis (AS) undergoing transcatheter valve implantation (TAVI), as they significantly impact outcomes. We have previously developed an easily calculable index, TCBI (Triglycerides, total Cholesterol, Body weight Index), which has been validated a prognostic indicator various cardiovascular disease contexts. This study aimed to evaluate the of low on outcomes TAVI. Methods is part Japanese...
Transgenic rice plants overexpressing a mutant gene for anthranilate synthase alpha subunit (OASA1D) accumulate large amounts of free tryptophan (Trp) with few adverse effects on the phenotype, except poor germination and weak seedling growth. Metabolic profiling 8-d-old seedlings Nipponbare two high-Trp lines, HW1 HW5, by high performance liquid chromatography-photo diode array (HPLC-PDA) confirmed that, relative to Nipponbare, only peak attributed Trp was significantly changed in profiles...
Genome-wide association studies and preclinical demonstrated a role of sortilin in lipid metabolism, inflammation, vascular calcification-all cardiovascular risk factors. We evaluated the serum levels with major adverse cerebrovascular events (MACCE) severity abdominal aortic calcification (AAC).A cohort community-dwelling men aged ≥50 years (n=830) was assessed. At baseline, were measured by ELISA, AAC assessed on lateral spine scans obtained dual-energy X-ray absorptiometry. Men ≥60...
Objective— Despite its large clinical impact, the underlying mechanisms for vein graft failure remain obscure and no effective therapeutic solutions are available. We tested hypothesis that Notch signaling promotes disease. Approach Results— used 2 biotherapeutics Delta-like ligand 4 (Dll4), a ligand: (1) blocking antibody (2) macrophage- or endothelial cell (EC)–targeted small-interfering RNA. Dll4 administration 28 days inhibited lesion development in low-density lipoprotein (LDL)...