A5000154980- Atherosclerosis and Cardiovascular Diseases
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- PARP inhibition in cancer therapy
- Diet, Metabolism, and Disease
- Chronic Kidney Disease and Diabetes
- Diabetes and associated disorders
- SARS-CoV-2 detection and testing
- Cardiac electrophysiology and arrhythmias
- Diabetes Management and Research
- Childhood Cancer Survivors' Quality of Life
- Inflammasome and immune disorders
- Toxin Mechanisms and Immunotoxins
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Acute Kidney Injury Research
- COVID-19 and Mental Health
- Dialysis and Renal Disease Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Hematopoietic Stem Cell Transplantation
- Phagocytosis and Immune Regulation
- COVID-19 diagnosis using AI
Brigham and Women's Hospital
2018-2024
Harvard University
2018-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2022-2023
Instituto do Câncer do Estado de São Paulo
2022
Universidade de São Paulo
2021
Universidade Cidade de São Paulo
2021
Chronic kidney disease (CKD) increases cardiovascular risk. Underlying mechanisms, however, remain obscure. The uremic toxin indoxyl sulfate is an independent risk factor in CKD. We explored the potential impact of on proinflammatory activation macrophages and its underlying mechanisms.We examined vitro effects clinically relevant concentrations responses roles organic anion transporters transporting polypeptides (OATPs). A systems approach, involving unbiased global proteomics,...
Objective Professionals working in intensive care units (ICUs) during the COVID-19 pandemic have been exposed to stressful situations and increased workload. The association between symptoms of traumatic stress disorders, substance abuse personal/occupational characteristics Brazilian COVID-19-ICU workers is still be addressed. Our aim was evaluate prevalence those conditions find if associations exist. Methods In this observational, single-center, cross-sectional study, all professionals a...
Interferon-γ (IFNγ) signaling plays a complex role in atherogenesis. IFNγ stimulation of macrophages permits vitro exploration proinflammatory mechanisms and the development novel immune therapies. We hypothesized that study macrophage subpopulations could lead to anti-inflammatory interventions.
Abstract The coronavirus disease (COVID-19) pandemic has occurred in Massachusetts multiple waves led by a series of emerging variants. While the evidence linked obesity with severe symptoms COVID-19, effect on susceptibility to SARS-CoV-2 infection remains unclear. Identification intrinsic factors, which increase likelihood exposed individuals succumbing productive could help plan mitigation efforts curb illness. We aim investigate whether obese have higher developing given comparable...
Identification of the SARS-CoV-2 virus by RT-PCR from a nasopharyngeal swab sample is common test for diagnosing COVID-19. However, some patients present clinical, laboratorial, and radiological evidence COVID-19 infection with negative result(s). Thus, we assessed whether positive results were associated intubation mortality. This study was conducted in Brazilian tertiary hospital March to August 2020. All had laboratory, diagnosis They divided into two groups: (+) group, 2292 participants,...
ADP-ribosylation is a post-translational modification that catalyzed by the ADP-ribosyltransferase enzyme family. Major emphasis to date has been ADP-ribosylation's role in cancer; however, there growing interest its inflammation and cardiovascular disease. Despite recent boom mass spectrometry-based proteomics, are limited computational resources evaluate quality of reported ADP-ribosylated (ADPr) proteins. We recently developed novel spectral annotation strategy (RiboMaP) facilitates...
Background: Inflammation and lipid accumulation are major features of atherosclerosis, a leading cause death morbidity worldwide. Our previous study recognized ADP-ribosylation, post-translational modification, as novel regulator macrophage activation. We also have established mass spectrometry-based ADP-ribosylation proteomics. Using this technology, we evaluated the completely uncharacterized role in atherogenesis. hypothesized that ADP-ribosylated proteins circulate from liver, accumulate...
Background: People living with HIV (PLWH) on anti-retroviral therapy remain at risk for cardiovascular diseases, including atherosclerosis. We hypothesized that persistent viral protein (HIV-Nef) in extracellular vesicles (EVs) modulate macrophage heterogeneity to impair atheroprotective efferocytosis accelerate disease. Methods and Results: Macrophage was characterized human primary macrophages (50,931 cells; 4 donors) stimulated EVs engineered contain HIV-Nef by simultaneous scRNAseq...
Autologous hematopoietic stem cell transplantation (ASCT) is the long-term consolidation treatment for various hematological malignancies. The collection of yield critical to successful ASCTs, but not always achieved due mobilization failure (HSCMF). Details regarding and outcomes those who fail are still lacking. Therefore, this study aimed data on clinical cellular products after HSCMF.
Background: In the era of modern Anti-Retroviral Therapy, people living with HIV continue to remain at a higher risk than general population for cardiovascular diseases including atherosclerosis. We hypothesized that circulating extracellular vesicles (EV) containing HIV-Nef protein promote inflammation by switching pattern macrophage heterogeneity towards pro-inflammatory state underlies disease. Methods & Results: Human primary macrophages were stimulated EV engineered contain HIV-Nef....