A5101676042- Sphingolipid Metabolism and Signaling
- Atherosclerosis and Cardiovascular Diseases
- Erythrocyte Function and Pathophysiology
- Lipid Membrane Structure and Behavior
- Traditional Chinese Medicine Studies
- melanin and skin pigmentation
- Herpesvirus Infections and Treatments
- Natural product bioactivities and synthesis
- Nutrition, Genetics, and Disease
- Synthesis of Organic Compounds
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Berry genetics and cultivation research
- Single-cell and spatial transcriptomics
- Protein Kinase Regulation and GTPase Signaling
- Traditional Chinese Medicine Analysis
- Lipid metabolism and disorders
- Biochemical effects in animals
- Plant Reproductive Biology
- Marine Toxins and Detection Methods
- Inflammatory Biomarkers in Disease Prognosis
- Peroxisome Proliferator-Activated Receptors
- Phagocytosis and Immune Regulation
- Antiplatelet Therapy and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
Minzu University of China
2024
Shanghai Veterinary Research Institute
2024
Chinese Academy of Agricultural Sciences
2024
Harvard University
2023-2024
Brigham and Women's Hospital
2022-2024
Inner Mongolia International Mongolian Hospital
2014
Shanghai Sixth People's Hospital
2011-2013
Renji Hospital
2013
Xiamen University
2010
Yinchuan First People's Hospital
2009
Interferon-γ (IFNγ) signaling plays a complex role in atherogenesis. IFNγ stimulation of macrophages permits vitro exploration proinflammatory mechanisms and the development novel immune therapies. We hypothesized that study macrophage subpopulations could lead to anti-inflammatory interventions.
Since blood platelets release sphingosine 1-phosphate (Sph-1-P) upon activation, it is important to examine the effects of this bioactive lipid on vascular endothelial cell functions from viewpoint platelet-endothelial interactions. In present study, we examined Sph-1-P-stimulated signaling pathways related human umbilical vein (HUVEC) motility, with a special emphasis cytoskeletal docking protein Crk-associated substrate (Cas). Sph-1-P stimulated tyrosine phosphorylation Cas, which was...
In this study, we examined the metabolism of [<sup>3</sup>H]N-hexanoylsphingosine [C<sub>6</sub>-ceramide (Cer)] in neutrophils, erythrocytes, platelets and mononuclear cells. [<sup>3</sup>H]C<sub>6</sub>-Cer, exogenously added incorporated into inside cell, was found to be converted other radioactive sphingolipids these differentiated blood cells, except which were unable metabolize C<sub>6</sub>-Cer. Only neutrophils a specific...
mass index, waistline, hipline, blood sugar, urea nitrogen, creatinine, uric acid, total cholesterol, triglyceride, and low-density lipoprotein levels were all significantly higher in the hypertensive group (P < 0.01).Hypertensives consumed less milk, vegetables, fruits, had cigarette, alcohol, salt intake 0.05).There also regular physical exercisers manual workers among 0.05).The mean inheritance rank of was than that controls no differences distribution genotype allele frequencies six SNPs...
Since sphingosine 1-phosphate (Sph-l-P) is stored in abundant amounts blood platelets and released extracellularly upon stimulation, it important to clarify the effects of this bioactive lysophospholipid on vascular endothelial cells from viewpoint platelet-endothelial cell interactions. In study, we investigated Sph-l-P cytoskeletal remodeling human umbilical vein (HUVECs). Of a focal adhesion kinase (FAK) family non-receptor protein-tyrosine Mnases, HUVECs were found express FAK, but...
Methicillin-resistant
Background: Inflammation and lipid accumulation are major features of atherosclerosis, a leading cause death morbidity worldwide. Our previous study recognized ADP-ribosylation, post-translational modification, as novel regulator macrophage activation. We also have established mass spectrometry-based ADP-ribosylation proteomics. Using this technology, we evaluated the completely uncharacterized role in atherogenesis. hypothesized that ADP-ribosylated proteins circulate from liver, accumulate...
Background: People living with HIV (PLWH) on anti-retroviral therapy remain at risk for cardiovascular diseases, including atherosclerosis. We hypothesized that persistent viral protein (HIV-Nef) in extracellular vesicles (EVs) modulate macrophage heterogeneity to impair atheroprotective efferocytosis accelerate disease. Methods and Results: Macrophage was characterized human primary macrophages (50,931 cells; 4 donors) stimulated EVs engineered contain HIV-Nef by simultaneous scRNAseq...
Bacteria biofilm infection seriously challenges clinical drug therapy. Nitric oxide (NO) was reported to disperse biofilm, eliminate bacteria resistance and kill bacteria. In this study, on the basis of membrane targeting α-mangostin (α-MG) dispersion effect NO biofilms, we designed synthesized 30 donors that α-MG conjugated with a nitrobenzene or nitrate other four representative reference derivatives. Compound 23 2-chloro-4-nitrobenzoyl introduced in position C6 exhibited prominent ability...
Objective To establish a polycystic ovary syndrome (PCOS) rat model and compare the expression of testosterone converting enzymes in adipose tissue PCOS with that controls.Methods 21-dayold female SD rats were divided into two groups:group A(control group):feed pellets injected oil; group B (model group):fed high fat diet dehydroepiandrosterone.After 9 weeks breeding,metabolic parameters,the morphologic changes analyzed.Results Compared A,fasting blood glucose,insulin,testosterone,and...
Objective To investigate the incidence of aspirin resistance (AR) in patients with Type Ⅱ Diabetes mellitus (DM) and correlation between AR advanced glycosylation end products (AGEs) as well homeostasis model assessment for insulin index (HOMA-IR). Methods A total 69 DM another 23 without control group were enrolled October 2009 July 2010. Blood lipid, blood routine, fasting glucose, Glycated hemoglobin (GHb/Hb A1c) ,fasting determined at first. After treatment least 7 days, platelet...
Objective To investigates a group of 2 candidate single nucleotide polymorphisms in P2Y1 gene the blood platelet aggregation pathway associated with aspirin resistance (AR).Methods A total 330 patients Emergency wards and Cardiovascular Department Shanghai Sixth People' s Hospital were enrolled from October 2010 to March 2012.All subjects examined including TC、TG、HDL-C、LDL-C,blood routine,fasting glucose (FBG).Following course treatment for at least 7 days,platelet stimulated by arachidonic...