A5101908693- Antimicrobial Peptides and Activities
- Polydiacetylene-based materials and applications
- Morinda citrifolia extract uses
- Microbial Metabolites in Food Biotechnology
- Mitochondrial Function and Pathology
- Carbohydrate Chemistry and Synthesis
- Phytochemistry and biological activity of medicinal plants
- Bacterial biofilms and quorum sensing
- Bioactive Compounds and Antitumor Agents
- GABA and Rice Research
- Probiotics and Fermented Foods
- Marine Toxins and Detection Methods
- Antimicrobial agents and applications
Shanghai Veterinary Research Institute
2023-2024
Chinese Academy of Agricultural Sciences
2023-2024
Ministry of Agriculture and Rural Affairs
2024
Bacterial infections pose a threat to human and animal health, the formation of biofilm exacerbates microbial threat.
Bacteria biofilm infection seriously challenges clinical drug therapy. Nitric oxide (NO) was reported to disperse biofilm, eliminate bacteria resistance and kill bacteria. In this study, on the basis of membrane targeting α-mangostin (α-MG) dispersion effect NO biofilms, we designed synthesized 30 donors that α-MG conjugated with a nitrobenzene or nitrate other four representative reference derivatives. Compound 23 2-chloro-4-nitrobenzoyl introduced in position C6 exhibited prominent ability...