The correlation between aspirin resistance in patients with diabetes and AGEs and HOMA-IR

• DOI: 10.3760/cma.j.issn.1671-0282.2011.02.021
• Publication Date: 2011-02-10
• Authors: Yongxia Li; Dong-cheng Shi; Lijuan Yan; Ge Rile; Jiamei Jiang; Yang Liu; Jian Sun; Feng Qi-ming
• Keywords: Glycated hemoglobin

Objective To investigate the incidence of aspirin resistance (AR) in patients with Type Ⅱ Diabetes mellitus (DM) and correlation between AR advanced glycosylation end products (AGEs) as well homeostasis model assessment for insulin index (HOMA-IR). Methods A total 69 DM another 23 without control group were enrolled October 2009 July 2010. Blood lipid, blood routine, fasting glucose, Glycated hemoglobin (GHb/Hb A1c) ,fasting determined at first. After treatment least 7 days, platelet aggregation stimulated by arachidonic acid(AA) adenosine diphosphate (ADP) measured. In addition, level serum AGEs was measured using ELISA assay. The degree obtained HOMA-IR. Results higher than that controls(30.4% vs. 8.7%, P = 0.037 ); levels HOMA-IR those controls [ (359.56 ± 120. 14) pg/mL (275.45 118.06)pg/mL, P=0. 004; (4.42 ±4.78) ( 1.5 ±0.78), P＜0.01, respectively]; AA diabetic correlated HOMA-IR( R =0.463, ＜0.01; R=0.290, =0.016, respectively); ADP only positively HOMA-IR(R =0.242, 0.045). Conclusions is controls, diabetics are more likely to develop resistant.

Key words: Diabetes Mellitus; Aspirin; Resistance; AGEs; HOMA-IR; Platelet; Platelet