A5054456656- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Angiogenesis and VEGF in Cancer
- Cardiac electrophysiology and arrhythmias
- Peripheral Artery Disease Management
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cerebrovascular and Carotid Artery Diseases
- Congenital heart defects research
- Cardiac Arrhythmias and Treatments
- Lymphatic System and Diseases
- Pulmonary Hypertension Research and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac pacing and defibrillation studies
- Diabetes Treatment and Management
- Bone fractures and treatments
- Orthopaedic implants and arthroplasty
- Nuclear Receptors and Signaling
- Genetic and Kidney Cyst Diseases
- Orthopedic Surgery and Rehabilitation
- Cardiac Structural Anomalies and Repair
- Renal Diseases and Glomerulopathies
- Aortic aneurysm repair treatments
- Aortic Thrombus and Embolism
- Photoacoustic and Ultrasonic Imaging
NTT Medical Center
2011-2024
Stanford University
2017-2022
Cardiovascular Institute of the South
2020-2021
Yokohama City University Medical Center
2018
Yokohama City University
2018
Teikyo University Chiba Medical Center
2013-2017
The University of Tokyo
2012-2015
Angiotensin-converting enzyme 2 (ACE2) is known as a negative regulator of the renin–angiotensin system. We aimed to determine roles ACE2 on development vascular diseases. Using two diversely different models diseases, hyperlipidaemia-induced atherosclerosis in apolipoprotein E knockout (KO) mice and mechanical injury-induced arterial neointimal hyperplasia C57Bl6 mice, we examined whether deficiency could affect formation lesions. resulted significantly larger lesions both aortic...
Immunoglobulin G4 (IgG4)-related systemic disease was first recognized as a clinicopathological entity about 10 years ago, and since then, it has attracted growing attention. It is an autoimmune which affects multiple organs including the pancreas, bile duct, salivary glands retroperitoneum. Further, recently reported that can be manifested periarteritis, often inflammatory abdominal aortic aneurysm. We describe case of 75-year-old man with pancreatitis parotitis who presented angina. The...
Thrombotic microangiopathy (TMA) is a rare but lethal multisystem disease characterized by peripheral thrombocytopenia, microangiopathic hemolytic anemia, fever, and various stages of renal neurological dysfunctions.1,2) The causes TMA are mainly thrombotic thrombocytopenic purpura (TTP) or hemolytic-uremic syndrome (HUS), cases related to myelodysplastic (MDS) quite rare. Herein, we report case acute myocardial infarction (AMI) caused which strongly suspected have relationship MDS, discuss...
Stent edge-related restenosis (SER) remains a potential limitation of drug-eluting stent (DES). Hinge motion at the edge could lead to mechanical stress and contribute incidents SER. We investigated effect hinge on SER after implantation current-generation DES in right coronary artery (RCA), where excessive vessel movement is commonly observed.
Despite previous reports indicating that in-stent tissue protrusion is not associated with worse clinical outcome, its natural history remains unclear. This the first to describe of thrombus post-stenting, using multimodal imaging.
Device underexpansion is associated with late adverse outcomes after bioresorbable vascular scaffold (BVS) implantation. This study, representing official IVUS results of the ABSORB Japan trial, aimed to characterize findings, focusing specifically on acute device expansion, and investigate its impact lumen loss (LLL) Absorb-BVS compared cobalt-chromium everolimus-eluting stents (CoCr-EES).ABSORB enrolled 148 patients (2:1 randomization) in cohort. Serial was prescheduled at post-procedure 3...
Most cases of cholesterol embolism are known to be triggered by cardiac catheterization, cardiovascular surgery, anticoagulation, or fibrinolytic therapy; however, spontaneous after aortic dissection rare. In this report, we describe a case type B dissection, which rapidly developed into multiple organ failure and death.A 65-year-old man with untreated hypertension was admitted our hospital sudden back pain diagnosed dissection. The patient experienced rapid progression inflammation...
Mechanism of femoropopliteal in-stent restenosis has been underappreciated. The aim this animal study was to elucidate vascular response after bare nitinol self-expanding stents (SESs) implantation. Misago, Smart Flex, or Innova stent randomly implanted in 36 swine arteries. At week 4, quantitative vessel analysis (QVA) performed on legs, which 18 underwent histological evaluation angiography. remaining legs QVA and at 13. Fibrin deposition excessive 4. Internal elastic lamina (IEL)...
We describe a patient with torsades de pointes (TdP) who was implanted cardiac resynchronization therapy defibrillator (CRT-D).At the time of CRT-D implantation, left ventricular (LV) epicardial pacing exacerbated TdPs and developed into electrical storm, which triggered even by biventricular pacing.We needed to inactivate LV lead for 2 weeks.At next device check testing still induced TdPs, whereas did not.After starting continuous no arrhythmias happened, furthermore QT intervals prolonged...
Background: Recent studies have suggested that late outgrowth endothelial progenitor cells (EPCs) emerging from cultured peripheral blood mononuclear (PBMNCs) might higher angiogenic potential than of classically defined early EPCs (EOCs). However, it still remains undetermined which EPC subpopulations rigorously by the time emergence has highest therapeutic potency. Methods and Results: Human PBMNCs freshly isolated were under cell conditions. EOCs as attached on culture plates at days 3 to...