A5073361917- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Artery Disease Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Atherosclerosis and Cardiovascular Diseases
- Aortic Thrombus and Embolism
- Cardiovascular Disease and Adiposity
- Aortic aneurysm repair treatments
- Venous Thromboembolism Diagnosis and Management
- Optical Coherence Tomography Applications
- Protease and Inhibitor Mechanisms
- Cardiac Valve Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Vascular Procedures and Complications
- Atrial Fibrillation Management and Outcomes
- Coronary Artery Anomalies
- Angiogenesis and VEGF in Cancer
- Kawasaki Disease and Coronary Complications
- Cardiac tumors and thrombi
- Sarcoidosis and Beryllium Toxicity Research
- Cardiac Health and Mental Health
Kitasato University
2017-2025
Kitasato University Hospital
2017-2024
Massachusetts General Hospital
2014-2023
Harvard University
2014-2023
Institute of Cardiology
2015-2017
Harbin Medical University
2014-2017
Second Affiliated Hospital of Harbin Medical University
2014-2017
Ministry of Education
2017
Kyung Hee University
2015-2017
Massachusetts Institute of Technology
2014-2016
Background— Optical coherence tomography (OCT) was recently introduced to optimize percutaneous coronary intervention. However, the exact incidence and significance of poststent OCT findings are unknown. Methods Results— A total 900 lesions treated with 1001 stents in 786 patients who had postprocedure imaging were analyzed evaluate identify predictors for device-oriented clinical end points, including cardiac death, target vessel–related myocardial infarction, lesion revascularization,...
Background— Whether triple antiplatelet therapy is superior or similar to dual in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention the era of drug-eluting stents remains unclear. Methods and Results— A total 4203 who underwent were analyzed retrospectively Korean Acute Myocardial Infarction Registry (KAMIR). They received either (aspirin plus clopidogrel; group; n=2569) clopidogrel cilostazol; n=1634) therapy. The group...
Background Plaque erosion is responsible for 25% to 40% of patients with acute coronary syndromes ( ACS ). Recent studies suggest that anti‐thrombotic therapy without stenting may be an option this subset patients. Currently, however, invasive procedure required make a diagnosis plaque erosion. The aim study was identify clinical or laboratory predictors in enable additional procedures. Methods and Results Patients who underwent optical coherence tomography imaging were selected from 11...
Angiotensin-converting enzyme 2 (ACE2) is known as a negative regulator of the renin–angiotensin system. We aimed to determine roles ACE2 on development vascular diseases. Using two diversely different models diseases, hyperlipidaemia-induced atherosclerosis in apolipoprotein E knockout (KO) mice and mechanical injury-induced arterial neointimal hyperplasia C57Bl6 mice, we examined whether deficiency could affect formation lesions. resulted significantly larger lesions both aortic...
Plaque rupture may be the local expression of a widespread coronary instability. This study aimed to investigate: (1) prevalence and characteristics nonculprit plaque rupture; (2) pancoronary atherosclerotic phenotype in patients with without (3) predictors multiple ruptures.Six hundred seventy-five plaques from 261 (34 acute myocardial infarction, 73 unstable angina pectoris, 154 stable pectoris) were analyzed by 3-vessel optical coherence tomography. Nonculprit ruptures identified 51...
BACKGROUND: It is not known whether there a sex difference in the association between perivascular inflammation and plaque vulnerability. The aim of this study was to investigate sex-specific METHODS: Patients who underwent coronary computed tomography angiography optical coherence were enrolled. All images analyzed at core laboratory. level assessed by pericoronary adipose tissue attenuation on vulnerability tomography. classified into 3 groups according tertile levels culprit vessel (low...
Myocardial no reflow after percutaneous coronary intervention (PCI) is associated with poor outcome. Patients ST-segment elevation myocardial infarction (STEMI) caused by plaque rupture are at high risk for reflow. However, specific morphologic characteristics unknown in this population. The aim of study to identify the morphological culprit plaques patients STEMI using both optical coherence tomography (OCT) and intravascular ultrasound (IVUS).We enrolled 145 who underwent OCT IVUS within...
Background— Spotty superficial calcium deposits have been implicated in plaque vulnerability based on previous intravascular imaging studies. Biomechanical models suggest that microcalcifications between 5 and 65 µm diameter can intensify fibrous cap stress, promoting rupture. However, the 100- to 200-µm resolution of ultrasound limits its ability discriminate single from clusters smaller deposits, a optical coherence tomographic investigation evaluated calcifications within long segment...
Objective: Healed plaques, signs of previous plaque destabilization, are frequently found in the coronary arteries. plaques can now be diagnosed living patients. We investigated prevalence, angiographic, and optical coherence tomography features healed patients with stable angina pectoris. Approach Results: Patients pectoris who had undergone imaging were included. defined as one or more signal-rich layers different density. divided into 2 groups based on layered nonlayered phenotype at...
Despite the significant decline in cardiovascular mortality women over past several decades, sex differences underlying pathology of acute coronary syndromes remain poorly understood. Previous postmortem studies have demonstrated plaque morphology with a higher prevalence erosion young and more rupture older after menopause, whereas men showed no increase age. However, vivo data are limited.This study included patients who presented syndrome underwent preintervention optical coherence...
Comprehensive management of acute coronary syndrome (ACS) requires seamless treatment across institutions, including intensive care centers and local clinics. However, maintaining guideline-directed medical therapy remains challenging. One promising option to improve the situation may be implementation regional collaborative clinical pathways. This study evaluated prevalence functionality such pathways for ACS in Japan. A nationwide survey was conducted through questionnaires web searches,...
Layered plaques represent signs of previous plaque destabilization. A recent study showed that acute coronary syndrome (ACS) patients with layered culprit have more vulnerability at the lesion and systemic inflammation. We aimed to compare characteristics non-culprit between or without lesion. also evaluated plaques, irrespective phenotype.We studied ACS who had undergone pre-intervention optical coherence tomography (OCT) imaging. The number lesions was on angiogram morphological were by...