A5105881702- Coronary Interventions and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Cerebrovascular and Carotid Artery Diseases
- ATP Synthase and ATPases Research
- Peripheral Artery Disease Management
- Mitochondrial Function and Pathology
- Aortic aneurysm repair treatments
- Urologic and reproductive health conditions
- Cardiac Imaging and Diagnostics
- Ovarian cancer diagnosis and treatment
- COVID-19 Clinical Research Studies
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Nuclear Receptors and Signaling
- Acute Myeloid Leukemia Research
- Renal cell carcinoma treatment
- Prostate Cancer Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Chronic Myeloid Leukemia Treatments
- Intraperitoneal and Appendiceal Malignancies
- Optical Coherence Tomography Applications
- Vascular Procedures and Complications
- Chronic Lymphocytic Leukemia Research
- Cancer Research and Treatments
- Eosinophilic Disorders and Syndromes
University of California, Irvine
2022-2025
City of Hope
2018-2024
Beth Israel Deaconess Medical Center
2024
Samsung Medical Center
2024
Sungkyunkwan University
2024
University of Ottawa
2006-2023
American Association For Cancer Research
2023
The University of Texas MD Anderson Cancer Center
2020-2023
Morehouse School of Medicine
2023
DEVCOM Army Research Laboratory
2023
The immediate-early transcription factor NGFI-A (also called Egr-1, zif/268, or Krox-24) is thought to couple extracellular signals changes in gene expression. Although activins and inhibins regulate follicle-stimulating hormone (FSH) synthesis, no has been identified that exclusively regulates luteinizing (LH) synthesis. An analysis of NGFI-A-deficient mice derived from embryonic stem cells demonstrated female infertility was secondary LH-β deficiency. Ovariectomy led increased amounts...
Background— Optical coherence tomography (OCT) was recently introduced to optimize percutaneous coronary intervention. However, the exact incidence and significance of poststent OCT findings are unknown. Methods Results— A total 900 lesions treated with 1001 stents in 786 patients who had postprocedure imaging were analyzed evaluate identify predictors for device-oriented clinical end points, including cardiac death, target vessel–related myocardial infarction, lesion revascularization,...
T cell hybridomas require the immediate-early gene NGFI-B ( nur77 ) for receptor (TCR)-mediated apoptosis, a model negative selection of self-reactive cells. TCR-mediated death was examined in mice bearing an loss-of-function mutation, either by administration antibodies to CD3 (anti-CD3) or two well-characterized transgenic models expressing TCRs. Both extent and rate thymocyte were unimpaired. Anti-CD3-induced normal CD4 + peripheral cells, which is mediated predominantly Fas signaling...
Neuroinflammation is a well-characterized pathophysiology occurring in association with the progression of Parkinson's disease. Characterizing cellular and molecular basis neuroinflammation critical to understanding its impact on incidence PD other neurologic disorders. Inflammasomes are intracellular pro-inflammatory pattern-recognition receptors capable initiating propagating inflammation. These complexes well characterized innate immune system activity NLRP3 inflammasome has been reported...
Intraductal carcinoma of the prostate and high-grade prostatic intraepithelial neoplasia (PIN) have markedly different implications for patient care but can be difficult to distinguish in needle biopsies. In radical prostatectomies, we demonstrated that PTEN ERG immunostaining may helpful resolve this differential diagnosis. Here, tested whether these markers are diagnostically useful biopsy setting. Separate or combined immunostains were applied biopsies containing morphologically...
Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms loss of dopaminergic neurons the substantia nigra. Inflammation cell death are recognized aspects PD suggesting that strategies to monitor modify these processes may improve management disease. Inflammasomes pro-inflammatory intracellular pattern recognition complexes couple processes. The NLRP3 inflammasome responds sterile triggers initiate maturation inflammatory cytokines,...
Local hypoxemia and stasis trigger thrombosis. We have demonstrated previously that in a murine model of normobaric hypoxia pulmonary fibrin deposition is result expression tissue factor, especially oxygen-deprived mononuclear phagocytes (MPs). now show transcription factor early-growth-response gene product (Egr-1) rapidly activated hypoxia, both vitro vivo , responsible for hypoxic lung. MPs HeLa cells subjected to (pO 2 ≈13 torr) had increased levels transcripts (≈18-fold) an rate...
NGFI-A (also known as EGR-1, zif/268, and Krox-24) is a zinc finger transcription factor induced in many cell types by variety of growth differentiation stimuli. To determine if plays requisite role these processes, we used homologous recombination to mutate both alleles embryonic stem (ES) cells examined its effect on differentiation. We find that ES lacking exhibit similar rates serum-induced gene expression profiles compared wild-type parental cells. They are capable differentiating into...
The immediate-early gene NGFI-B encodes an orphan nuclear receptor that binds DNA as a monomer and activates transcription through canonical response element (NBRE). is expressed under basal conditions in to external stimuli many mammalian tissues. In particular, expression dramatically elevated the adrenal cortex stress Y1 adrenocortical cells adrenocorticotropin. NBRE of encoding 21-hydroxylase (P450c21) cells. Steroidogenic factor 1 (SF-1), homolog NGFI-B, also P450c21 promoter. To...
AbstractThe zinc finger protein NGFI-A (also called EGR1, Krox24, or zif268) is a candidate regulator of myeloid cell differentiation. Evidence supporting this hypothesis twofold. First, antisense oligonucleotides prevent macrophage differentiation in HL-60 and U937 leukemia lines normal bone marrow cells. Second, enforced expression blocks granulocytic promotes cells the hematopoietic progenitor line 32D. We sought to determine effect deficiency on function vivo by examining native from...
Mycophenolate-associated colitis has been previously reported to show patterns of colonic mucosal injury mimicking a host conditions, including graft-versus-host disease, ischaemia and inflammatory bowel disease (IBD). The aim this study is characterise, semiquantitatively, pathological changes mycophenolate mofetil (MMF) injury.Seven transplant patients receiving MMF who underwent colonoscopic examination biopsy were identified retrospectively over 2-year period. Multiple histologic...
<h3>Importance</h3> Venous thromboembolism is the second overall leading cause of death for patients with cancer, and there an approximately 2-fold increase in fatal pulmonary embolism (PE) cancer. Inferior vena cava (IVC) filters are designed to prevent PE, but defining appropriate use IVC cancer remains a substantial unmet clinical need. <h3>Objective</h3> To evaluate association development PE deep venous thrombosis (DVT). <h3>Design, Setting, Participants</h3> A population-based cohort...
In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon possible after acceptance. Accepted have been peer-reviewed and copyedited, but are posted before technical formatting author proofing. These not final version record will be replaced with article (formatted per style proofed by authors) at a later time. We describe timing first-dose sedation analgesia rapid sequence intubation (RSI) in patients induced etomidate paralyzed rocuronium or...
ABSTRACT The window period in hepatitis C virus (HCV) infection is still a major problem ensuring blood safety. HCV RNA detection by nucleic acid amplification technology-based tests has contributed to reduce the infectivity of products, but it expensive, time-consuming and affected high prevalence false-positive results. aim this study was assess performance newly developed enzyme immunoassay for core antigen its suitability use screening units order identify infecting samples that do not...
Eosinophilia of Peritoneal Fluid and Peripheral Blood Associated with Chronic Dialysis Get access Stephen Lee, M.D., M.D. Division Pathology, Cedars-Sinai Medical Center, Mount Sinai Division, 8720 Beverly Boulevard, Los Angeles, California Search for other works by this author on: Oxford Academic Google Scholar Irwin Schoen, American Journal Clinical Volume 47, Issue 5, 1 May 1967, Pages 638–640, https://doi.org/10.1093/ajcp/47.5.638 Published: 01 1967 Article history Received: August 1966
Abstract Background The Namibian Ministry of Health and Social Services (MoHSS) piloted the first HIV Project ECHO (Extension for Community Outcomes) in Africa at 10 clinical sites between 2015 2016. Goals implementation included strengthening capacity, improving professional satisfaction, reducing isolation while addressing service challenges during decentralization antiretroviral therapy. Methods MoHSS conducted a mixed-methods evaluation to assess pilot. pre/post program assessments...
Hyperthermic intraperitoneal chemotherapy (HIPEC) confers a survival benefit in epithelial ovarian cancer (EOC) and preclinical models. However, the molecular changes induced by HIPEC have not been corroborated humans.A feasibility trial evaluated clinical safety outcomes of with cisplatin during optimal cytoreductive surgery (CRS) patients EOC diagnosed stage III, IV, or recurrent EOC. Pre- post-HIPEC biopsies were comprehensively profiled genomic transcriptomic sequencing to identify...