A5052515112- European and International Law Studies
- Judicial and Constitutional Studies
- Ubiquitin and proteasome pathways
- BRCA gene mutations in cancer
- Long-Term Effects of COVID-19
- Legal principles and applications
- Cancer, Hypoxia, and Metabolism
- Conflict of Laws and Jurisdiction
- Law in Society and Culture
- Political Systems and Governance
- International Law and Aviation
- Ombudsman and Human Rights
- Genomics and Rare Diseases
- Glioma Diagnosis and Treatment
- PARP inhibition in cancer therapy
- RNA modifications and cancer
- International Law and Human Rights
- Intensive Care Unit Cognitive Disorders
- Family Support in Illness
- Smoking Behavior and Cessation
- Inflammasome and immune disorders
- Legal and Constitutional Studies
- Criminal Law and Evidence
- Global Cancer Incidence and Screening
- American Constitutional Law and Politics
University of Newcastle Australia
2022-2025
University of Otago
2025
Aneurin Bevan University Health Board
2024
Dartmouth College
2009-2023
The University of Sydney
2017-2023
Essex County Council
2023
Kingston Health Sciences Centre
2023
New South Wales Department of Primary Industries
2022
University of Cambridge
2005-2021
Washington State University
2021
Cells isolated from many types of human cancers express heparin-binding growth factors (HBGFs) that drive tumor growth, metastasis, and angiogenesis. The heparan sulfate proteoglycan glypican-1 (GPC1) is a coreceptor for HBGFs. Here we show both cancer cell-derived host-derived GPC1 are crucial efficient angiogenesis mouse cells. Thus downregulation in the pancreatic cell line PANC-1, using antisense approaches, resulted prolonged doubling times decreased anchorage-independent vitro as well...
Neuroinflammation is a well-characterized pathophysiology occurring in association with the progression of Parkinson's disease. Characterizing cellular and molecular basis neuroinflammation critical to understanding its impact on incidence PD other neurologic disorders. Inflammasomes are intracellular pro-inflammatory pattern-recognition receptors capable initiating propagating inflammation. These complexes well characterized innate immune system activity NLRP3 inflammasome has been reported...
Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms loss of dopaminergic neurons the substantia nigra. Inflammation cell death are recognized aspects PD suggesting that strategies to monitor modify these processes may improve management disease. Inflammasomes pro-inflammatory intracellular pattern recognition complexes couple processes. The NLRP3 inflammasome responds sterile triggers initiate maturation inflammatory cytokines,...
ABSTRACT Aim Smoking is a chronic relapsing condition that under‐reported in oncology settings. People who report current smoking (CS) and those recently quitting (RQ) should receive cessation support when they are diagnosed with cancer. The study aimed to identify whether differences exist the given CS RQ what advice regarding benefits of cessation. Method A survey exploring practices was completed by clinicians (medical, nursing, allied health) at nine cancer centers Australia. Data were...
Targeting of oncogenic Kras to the pancreatic Nestin-expressing embryonic progenitor cells and subsequently adult acinar compartment is sufficient for development low grade intraepithelial neoplasia (PanIN) between 2 4 months. The mice die around 6 month-old unrelated causes, it therefore not possible assess whether lesions will progress carcinoma. We now report that two brief episodes caerulein-induced acute pancreatitis in causes rapid PanIN progression ductal adenocarcinoma (PDAC) by...
Complex interactions between genetic and environmental factors are widely believed to underlie the incidence progression of Parkinson's disease (PD). Rotenone is a naturally occurring metabolic toxin employed as an insecticide piscicide identified risk factor for development PD in agricultural workers. The Nlrp3 inflammasome intracellular mediator that can initiate inflammatory cascade response cellular stress. Reports by others indicating NLRP3 expression was detectable tissues obtained...
To identify the approximately 12% with inherited cancer predisposition, all men metastatic prostate (mPC) should be offered germline genetic testing. This guides treatment choices and impacts prevention in family. Limited services globally present a barrier to study tested potential solution, "mainstreaming," where counseling testing are performed by patient's oncologist.Men mPC at three Australian sites were their medical oncology appointment. Panel (ATM, BRCA1, BRCA2, BRIP1, CHEK2, EPCAM,...
ABSTRACT Purpose Patients who smoke tobacco during and after a cancer diagnosis have poorer health outcomes. Oncology healthcare providers (HCPs) are crucial to providing smoking cessation support. The study examined the characteristics associated with differences in HCPs’ practices. Methods As part of Care Quit trial, cross‐sectional survey exploring practices was completed by HCPs across nine centers New South Wales Victoria, Australia. Results One hundred seventy‐seven survey. Over half...
The doctrine of deference permeates human rights review. It plays a role in defining Convention rights, determining the nature proportionality test applied when analysing non‐absolute as well deciding stringency its application. has recently been subjected to both judicial and academic criticism, some which advocates demise doctrine. This article develops contextual account that is justified for epistemic reasons, rather than reasons relative authority. conception able withstand current...
Abstract While family communication about a BRCA1 or BRCA2 ( BRCA1/2 ) pathogenic variant can be catalyst for the uptake of risk‐reducing measures in young adults, disseminating information within families and across generations is complex. This study aimed to explore how adults their communicate variant, from systems perspective. In‐depth interviews questionnaires N = 67 individuals; 21 families) were completed at four metropolitan regional genetic clinics Australia. Data involved thematic...
Abstract Glioblastoma is the most aggressive primary brain tumor and responds poorly to currently available therapies. Transcriptomic characterization of glioblastoma has identified distinct molecular subtypes glioblastoma. Gain-of-function alterations leading enhanced platelet-derived growth factor (PDGF) signaling are commonly observed in proneural subtype can drive gliomagenesis. However, little known about downstream effectors PDGF Using a mouse model glioma comparative transcriptomics,...