A5010571238- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Cervical Cancer and HPV Research
- Renal cell carcinoma treatment
- Colorectal Cancer Surgical Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Research and Treatments
- Surgical site infection prevention
- Minimally Invasive Surgical Techniques
- Chemotherapy-induced organ toxicity mitigation
- Hepatocellular Carcinoma Treatment and Prognosis
- Endometriosis Research and Treatment
- Maternal and fetal healthcare
- Urologic and reproductive health conditions
- Appendicitis Diagnosis and Management
- Histone Deacetylase Inhibitors Research
- Dermatological and Skeletal Disorders
- Skin Diseases and Diabetes
- Surgical Simulation and Training
- Ureteral procedures and complications
- Nuclear Receptors and Signaling
- Cancer, Lipids, and Metabolism
- Ectopic Pregnancy Diagnosis and Management
City Of Hope National Medical Center
2017-2025
City of Hope
2019-2023
Cleveland Clinic
2006-2015
Mayo Clinic
2010-2012
Woman's Cancer Foundation
2012
Wake Forest University
2010
Memorial Sloan Kettering Cancer Center
2007
The objectives of this study were to describe the rate and predictors surgical site infection (SSI) after gynecologic cancer surgery identify any association between SSI postoperative outcome.Patients with endometrial, cervical, or ovarian cancers from 2005 2011 identified American College Surgeons National Surgical Quality Improvement Program. extent intervention was categorized into modified complexity scoring (MSCS) system. Univariate multivariate logistic regression analyses used. Odds...
To evaluate intraoperative hypothermia as a predictor for morbidity after open abdominal surgery ovarian cancer.This cohort study included 146 women with stage IIIC and IV cancer who underwent debulking at our institution from January 1, 2001, through December 31, 2003. Hypothermia was defined end operative temperature lower than 36°C. Early complications (occurring within 30 days of surgery) included: mortality, infectious morbidities, cardiovascular events, venous thromboembolic (VTE)...
Hyperthermic intraperitoneal chemotherapy (HIPEC) confers a survival benefit in epithelial ovarian cancer (EOC) and preclinical models. However, the molecular changes induced by HIPEC have not been corroborated humans.A feasibility trial evaluated clinical safety outcomes of with cisplatin during optimal cytoreductive surgery (CRS) patients EOC diagnosed stage III, IV, or recurrent EOC. Pre- post-HIPEC biopsies were comprehensively profiled genomic transcriptomic sequencing to identify...
Pterostilbene (3,5-dimethoxy-40-hydroxystilbene) is a potent oral antioxidant with promising role in anti-cancer treatment. In endometrial cancer (EC), vitro studies demonstrated synergistic antiproliferative effect of pterostilbene (PT) megestrol acetate (MA), common treatment for EC. This randomized phase II clinical trial (NCT03671811) PT+MA vs. MA three weeks prior to scheduled hysterectomy. The primary objective determine the using Ki-67 index. secondary objectives are toxicity,...
The objective of this study was to estimate the prevalence and prognostic impact lymphadenectomy lymph node involvement in patients with ovarian clear cell carcinoma (OCCC) grossly confined ovary.Patients a diagnosis OCCC ovary were identified from Surveillance, Epidemiology, End Results program 1988 2007. Only surgically treated included. Statistical analysis using Student t test, Kaplan-Meier survival methods, Cox proportional hazards regression performed.One thousand eight hundred...
The purpose of this study was to determine if loss serine protease HtrA1 in endometrial cancer will promote the invasive potential EC cell lines.Western blot analysis and immunohistochemistry methods were used expression lines primary tumors, respectively. Migration, invasion assays vivo xenograft experiment performed compare extent metastasis between expressing knocked down clones.Western 13 revealed complete all seven papillary serous lines. Downregulation Hec1A Hec1B resulted a three-...
The aim of this study was to evaluate the efficacy adding bevacizumab paclitaxel and carboplatin as maintenance in a larger cohort patients with advanced or recurrent endometrial carcinoma.We retrospectively identified cancer treated (175 mg/m per 3 hours), (area under curve, 5) (15 mg/kg) post-protocol treatment evaluated them our previously published phase 2 trial regimen.Twenty-seven additional were identified; 19 received regimen first-line therapy, 8 second-line therapy after prior...
Hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin confers a survival benefit in epithelial ovarian cancer (EOC) but is associated renal toxicity. Sodium thiosulfate (ST) used for nephroprotection HIPEC cisplatin, standard practices vary.A prospective, nonrandomized, clinical trial evaluated safety outcomes of 75 mg/m2 during cytoreductive surgery (CRS) patients EOC (n = 34) and endometrial 6). Twenty-one received no ST (nST), 19 ST. Adverse events (AEs) were reported according...
The improved survival observed in recent years for women with ovarian cancer (OC) has not been realized among African American (AA) compared white (W) women. contribution of immediate postoperative morbidity and mortality to this disparity remains unclear. This study aims examine disparities 30-day between AA W OC.Patients OC were identified from the College Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) 2005 2011. subgroups studied. Multivariable logistic regression...
Peripartum hysterectomy is performed for a variety of indications, including abnormal placentation, retained placenta, uterine rupture, and atony. Most cases are emergent through open laparotomy.At 20 weeks gestation, patient with previous endometrial ablation had ruptured membranes delivered her fetus but not placenta. She was hemodynamically stable underwent robotic hysterectomy. Surgical pathology confirmed placenta increta.In appropriate patients, minimally invasive approach may be...