A5030220173- Inflammatory Bowel Disease
- Microscopic Colitis
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Mental Health Treatment and Access
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Pregnancy and Medication Impact
- Psoriasis: Treatment and Pathogenesis
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cardiac Health and Mental Health
- Bariatric Surgery and Outcomes
- Liver Disease Diagnosis and Treatment
- Eosinophilic Esophagitis
- Liver Diseases and Immunity
- Maternal Mental Health During Pregnancy and Postpartum
- Autoimmune and Inflammatory Disorders
- Eating Disorders and Behaviors
- Gastric Cancer Management and Outcomes
- Obesity and Health Practices
- Genetic factors in colorectal cancer
- Viral-associated cancers and disorders
- Pancreatitis Pathology and Treatment
- Diagnosis and treatment of tuberculosis
Australian National University
2013-2024
G.S. Science, Arts And Commerce College
2024
Canberra Hospital
2013-2023
Universiti Tunku Abdul Rahman
2011-2023
ACT Government
2012-2023
Advance (Japan)
2023
Universiti Sains Malaysia
2023
University of Malaya
2017-2021
Meenakshi Mission Hospital and Research Centre
2016
Government of Western Australia Department of Health
2012
IMPORTANCEUse of thiopurines may be limited by myelosuppression.TPMT pharmacogenetic testing identifies only 25% at-risk patients European ancestry.Among East Asian ancestry, NUDT15 variants are associated with thiopurine-induced myelosuppression (TIM).OBJECTIVE To identify genetic TIM among ancestry inflammatory bowel disease (IBD). DESIGN, SETTING, AND PARTICIPANTSCase-control study 491 affected and 679 thiopurine-tolerant unaffected who were recruited from 89 international sites between...
Summary Background Muscle wasting or sarcopenia arising from chronic inflammation is found in 60% of patients with Crohn's disease. Transcriptional protein NF ‐κB reduces muscle formation through MyoD transcription and increases breakdown by proteolysis. Aim As TNF a potent activator ‐κB, anti‐ agent infliximab ( IFX ) prevents activation, to determine whether not treated gain volume strength. Methods We performed prospective, repeated‐measures cohort study adult disease an acute flare....
Mycophenolate-associated colitis has been previously reported to show patterns of colonic mucosal injury mimicking a host conditions, including graft-versus-host disease, ischaemia and inflammatory bowel disease (IBD). The aim this study is characterise, semiquantitatively, pathological changes mycophenolate mofetil (MMF) injury.Seven transplant patients receiving MMF who underwent colonoscopic examination biopsy were identified retrospectively over 2-year period. Multiple histologic...
Summary Our aim was to identify the factors that influence care‐seeking behaviour of chest symptomatics in urban and rural areas South India. We conducted in‐depth interviews with 649 participants: 80% 310 residents 63% 339 people had sought care ( P < 0.01), 93% within 1 month onset symptoms. Private health facilities were first preferred point contact for 57% 48% participants; major reasons proximity residence their perception good‐quality would be available there. Symptomatics who did...
Background: Histologic activity is recognized as an important predictor of relapse in ulcerative colitis (UC) patients. Current treatment targets aim at mucosal healing; however, many patients continue to have histologic activity. Goals: The was assess using the validated Nancy index (NHI) score a future amongst UC endoscopic and clinical remission. Study: In this retrospective cohort study, remission single tertiary center between 2015 2018, who underwent surveillance colonoscopy were...
In the wound bed of chronic venous leg ulcers, an imbalance matrix metalloproteinases (MMPs) and tissue inhibitor (TIMPs) may cause excessive proteolysis impair granulation. Soluble mediators in environment be responsible for this imbalance. The vitro effect fluid from ulcers on dermal fibroblast production MMP-1, MMP-3 TIMP-1 was compared with acute two different sources: post-mastectomy axillary drains skin graft donor sites. Significantly higher MMP-1 levels were induced by ulcer both...
SUMMARY A 35‐year‐old morbidly obese woman on home haemodialysis presented with painful indurated subcutaneous nodules histologically characteristic of calciphylaxis. After failing to respond conventional treatment, she was commenced an intravenous infusion 25 g sodium thiosulfate three times per week. Two weeks after commencing thiosulfate, the pain resolved completely. By 12 weeks, lesions had healed and infusions were ceased. months later, skin recurred, but again within 3 recommencement...
Objective. This paper examines the factors contributing to under utilisation of health care services in Malaysian population. Methodology. Using data derived from Mental Health Survey (MMHS) information on four basic previous three months, namely contact with professionals, ward admissions, having diagnostic or laboratory tests done and being any medications were obtained. Results. A total 2202 out 3666 60% MMHS participants included this study. Thirty percent subjects (n = 664) had contacts...
BACKGROUND Blood products are commonly transfused for patients with nonvariceal upper gastrointestinal bleeding (NVUGIB). While concerns exist about further and mortality in subsets of receiving red blood cell (RBC) transfusion, the impact non‐RBC has not previously been systematically investigated. The aim study was to investigate associations between bleeding, after acute NVUGIB. STUDY DESIGN AND METHODS A retrospective cohort examined 30‐day 1‐year adult who underwent gastroscopy...
Discontinuation of anti-TNF before gestational week 30 did not increase the risk relapse in third trimester. Relapse and continuation throughout pregnancy were each independently associated with lower birth weight, a marker long-term adverse outcomes.
Bariatric surgery is currently the most durable weight loss solution for patients with morbid obesity. The extent of achieved, however, subject to variation due various factors, including patients’ behaviour. In this study, we aimed identify pre- and post-surgical predictors following bariatric surgery. This prospective study included 57 participants who went through (laparoscopic Roux-en-Y gastric bypass: n = 30; laparoscopic sleeve gastrectomy: 23; one anastomosis bypass-mini 4) in two...
Objectives: To determine the quality of life (QOL) after stapes surgery and whether audiological parameters for hearing correlate with specific QOL factors. Design: A retrospective cross‐sectional study. Setting: tertiary referral centre. Participants: series 35 patients who underwent which three were excluded because they <18 years age, chronically or mentally ill, in a dependant relationship. Response rate was 93% (30/32). Nine further had revision bilateral surgery, missing data....
Manual piston malcrimping in stapedotomy may be the major cause of occurrence significant, interindividual variations postoperative air-bone gap (ABG), closures (ABGC), and recurrences conductive hearing loss. To eliminate effects manual crimping on outcomes, self-crimping, shape memory alloy Nitinol stapes was investigated evaluated.Prospective, preliminary case-control study a tertiary care referral center.Sixteen patients with otosclerosis undergoing reversed using were matched to...
Anti-tumour necrosis factor (TNF) agents are used as induction and maintenance therapy in ulcerative colitis (UC) refractory to standard rescue acute severe UC (ASUC).To determine long-term outcomes including colectomy rates, predictors of response remission, risk serious adverse events by reviewing 12-year clinical experience from a single centre Australia.Seventy-one patients with moderate-severe (Mayo score ≥6) (n = 52) ASUC 19) treated anti-TNF were included. Primary end-points at 12...
Abstract Introduction Mental disorders are emerging as serious health threats in both developed and developing nations contribute to greater D isability A djusted L ife Y ears ( DALY ) than infectious disease unintentional injuries. This study aims determine the prevalence factors associated with presence of common mental M alaysian population. Methods Multistage cluster sampling method was used obtain samples, racial proportion main criteria. Required sample size calculated be 4300 at 90%...
Introduction: Glatiramer acetate (Copaxone), a polypeptide has been approved for treating patients with active relapsing–remitting multiple sclerosis. Case Presentation: We report the first case of severe acute hepatitis after commencing treatment sclerosis glatiramer acetate. A 31-year-old female presented anorexia, lethargy and jaundice five weeks She had never received beta-interferon treatment. Investigations revealed bilirubin 0.109 mmol/L (0.002-0.02 mmoL/L) prothrombin time 21 secs...
This study aims to investigate the psychometric properties of Malay version Dutch Eating Behaviour Questionnaire (DEBQ) among Malaysian adults.The DEBQ instrument was administered 398 outpatients (269 women and 129 men) at University Malaya Medical Centre (UMMC). Confirmatory Factor Analysis (CFA) conducted construct validity instrument. Composite reliability coefficient, Raykov's rho, used determine internal consistency.The proposed three-factor structure for appropriate, although three...
Summary Background Vedolizumab was shown to be effective and safe for patients with ulcerative colitis (UC) or Crohn's disease (CD) in the GEMINI phase 3 long‐term safety (LTS) studies. Aim To report treatment persistence results up 2 years after enrolment vedolizumab extended access programme (XAP) Methods XAP is a 3b/4, prospective, open‐label, multinational, interventional study. At rollover from LTS, who were experiencing continued clinical benefit received reduced dosing frequency every...
Several scoring systems are available to predict the outcome of liver cell failure. Scarce information is on predictors in hepatic encephalopathy.To study clinical and biochemical variables that would encephalopathy.Fifty consecutive patients with encephalopathy were included study. Variables parameters, discriminant function, QTc interval need for ventilator support. Child-Pugh's Turcotte score Mayo Clinic model end-stage disease scores calculated at admission. Patients followed up until...
To assess patients' quality of life after cerebellopontine angle surgery, and in particular, related to unilateral profound hearing loss.Cross-sectional a tertiary referral center. Quality 51 postoperative patients was assessed by using the Glasgow Benefit Inventory (GBI). Thirty with loss who had undergone translabyrinthine approach completed subsequent quality-of-life questionnaire on speech discrimination sound localization.Ninety-four percent respondents 2nd survey reported difficulties...
Introduction. There is evidence in the literature that there are associations between advancing paternal age and psychosis or more specifically schizophrenia, but not enough to support a strong link common mental disorders. Objective. This study aims explain association at birth disorders progeny during their adulthood. Methodology. sub-study from larger survey which was planned epidemiology of Malaysia. Respondents who could remember parents were included study. The diagnosis (CMD) made...