A5034851679- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cerebrovascular and Carotid Artery Diseases
- Heart Failure Treatment and Management
- Peripheral Artery Disease Management
- Aortic Thrombus and Embolism
- Optical Coherence Tomography Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Coronary Artery Anomalies
- Aortic aneurysm repair treatments
- Blood Pressure and Hypertension Studies
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac tumors and thrombi
- Cardiac pacing and defibrillation studies
- Diabetes Treatment and Management
- Cardiac Health and Mental Health
- Protease and Inhibitor Mechanisms
Nara Medical University
2015-2024
Nara Prefecture General Medical Center
2022-2024
Massachusetts General Hospital
2013-2023
Harvard University
2013-2023
Nara Medical University Hospital
2011-2022
Amyloidosis Foundation
2021
Research Network (United States)
2021
Harbin Medical University
2014-2017
Kyung Hee University
2015-2017
Ministry of Education
2014-2017
Morphological characteristics of non-significant coronary plaques (NSCPs) that develop rapid progression have not been fully elucidated. The aim this study was to clarify the morphological NSCPs in patients with artery disease (CAD) using intravascular optical coherence tomography (OCT). Fifty-three consecutive CAD undergoing percutaneous intervention were enrolled and 69 (per cent diameter stenosis <50%) identified on baseline angiogram. Baseline evaluated by OCT, followed-up prospectively....
Background— Optical coherence tomography (OCT) was recently introduced to optimize percutaneous coronary intervention. However, the exact incidence and significance of poststent OCT findings are unknown. Methods Results— A total 900 lesions treated with 1001 stents in 786 patients who had postprocedure imaging were analyzed evaluate identify predictors for device-oriented clinical end points, including cardiac death, target vessel–related myocardial infarction, lesion revascularization,...
Background Plaque erosion is responsible for 25% to 40% of patients with acute coronary syndromes ( ACS ). Recent studies suggest that anti‐thrombotic therapy without stenting may be an option this subset patients. Currently, however, invasive procedure required make a diagnosis plaque erosion. The aim study was identify clinical or laboratory predictors in enable additional procedures. Methods and Results Patients who underwent optical coherence tomography imaging were selected from 11...
Plaque rupture may be the local expression of a widespread coronary instability. This study aimed to investigate: (1) prevalence and characteristics nonculprit plaque rupture; (2) pancoronary atherosclerotic phenotype in patients with without (3) predictors multiple ruptures.Six hundred seventy-five plaques from 261 (34 acute myocardial infarction, 73 unstable angina pectoris, 154 stable pectoris) were analyzed by 3-vessel optical coherence tomography. Nonculprit ruptures identified 51...
Background Plaque rupture and erosion are the 2 most common mechanisms for acute coronary syndromes. However, outcome of these distinct pathologies in patients with syndromes has never been studied. Methods Results We retrospectively studied 141 who underwent optical coherence tomography ( OCT ) imaging culprit lesion prior to stenting from Massachusetts General Hospital Registry. Management (stent versus no stent), poststent findings, outcomes were compared. Among lesions, was found 79...
BackgroundBrain natriuretic peptide (BNP) and amino-terminal proBNP (NT-proBNP) are useful biomarkers for diagnosis prediction of prognosis. Both these peptides elevated in patients with chronic kidney disease (CKD), but there is no evidence as to which the more suitable biomarker severe renal dysfunction.Methods resultsThis retrospective cohort study evaluated cardiovascular diseases (64.9 ± 11.7 years, mean SD). The end points were all-cause death a composite point death, nonfatal...
Myocardial no reflow after percutaneous coronary intervention (PCI) is associated with poor outcome. Patients ST-segment elevation myocardial infarction (STEMI) caused by plaque rupture are at high risk for reflow. However, specific morphologic characteristics unknown in this population. The aim of study to identify the morphological culprit plaques patients STEMI using both optical coherence tomography (OCT) and intravascular ultrasound (IVUS).We enrolled 145 who underwent OCT IVUS within...
Background— Spotty superficial calcium deposits have been implicated in plaque vulnerability based on previous intravascular imaging studies. Biomechanical models suggest that microcalcifications between 5 and 65 µm diameter can intensify fibrous cap stress, promoting rupture. However, the 100- to 200-µm resolution of ultrasound limits its ability discriminate single from clusters smaller deposits, a optical coherence tomographic investigation evaluated calcifications within long segment...
Objective: Healed plaques, signs of previous plaque destabilization, are frequently found in the coronary arteries. plaques can now be diagnosed living patients. We investigated prevalence, angiographic, and optical coherence tomography features healed patients with stable angina pectoris. Approach Results: Patients pectoris who had undergone imaging were included. defined as one or more signal-rich layers different density. divided into 2 groups based on layered nonlayered phenotype at...
Despite the significant decline in cardiovascular mortality women over past several decades, sex differences underlying pathology of acute coronary syndromes remain poorly understood. Previous postmortem studies have demonstrated plaque morphology with a higher prevalence erosion young and more rupture older after menopause, whereas men showed no increase age. However, vivo data are limited.This study included patients who presented syndrome underwent preintervention optical coherence...
We aimed to validate a claims-based diagnostic algorithm identify hospitalized patients with acute major cardiovascular diseases (CVDs) from health insurance claims in Japan.
Late stent thrombosis related to delayed neointimal growth is a major concern after drug-eluting (DES) implantation. The time course of and risk factors uncovered struts sirolimus-eluting (SES) was studied using optical coherence tomography (OCT).The 60 patients were enrolled classified into G1 (follow-up period <9 months, n=27), G2 (9-24 n=18), G3 (>25 n=15). elapsed since SES implantation associated with significant increase in mean area thickness, also decrease the number (G1: 14.8%, G2:...
Accumulating evidence suggests that hematopoiesis, especially erythropoiesis, is disturbed in heart failure (HF) for many reasons. Low hemoglobin and red blood cell distribution width have emerged as prognostic indicators of HF independent classic predictors. The implication mean corpuscular volume (MCV) HF, however, unknown. In this context, we investigated the relationship between MCV prognosis acute decompensated (ADHF).This retrospective cohort study consisted 458 consecutive patients...