A5077670585- Acute Myocardial Infarction Research
- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Diabetes Treatment and Management
- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Nutrition and Health in Aging
- Cardiovascular Disease and Adiposity
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Fibrosis and Remodeling
- Cancer, Lipids, and Metabolism
- Erythropoietin and Anemia Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Peptidase Inhibition and Analysis
- Frailty in Older Adults
- Pancreatic function and diabetes
- Cardiovascular Health and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Metabolism, Diabetes, and Cancer
- Cardiac and Coronary Surgery Techniques
- Chemokine receptors and signaling
- Neuroendocrine Tumor Research Advances
- Apelin-related biomedical research
Juntendo University
2018-2025
Juntendo University Nerima Hospital
2021-2022
Sakakibara Hospital
2019-2021
Juntendo University Hospital
2020
Abstract Background The nutritional status and frailty are crucial in patients with aortic stenosis (AS) undergoing transcatheter valve implantation (TAVI), as they significantly impact outcomes. We have previously developed an easily calculable index, TCBI (Triglycerides, total Cholesterol, Body weight Index), which has been validated a prognostic indicator various cardiovascular disease contexts. This study aimed to evaluate the of low on outcomes TAVI. Methods is part Japanese...
Background and aims Pathophysiological roles of monocytes in atrial fibrillation (AF), particularly for the progression structural remodeling left atrium (LA), remain elusive. This study examined association between characteristics circulating local extent LA, gauged by LA size, AF patients. Methods First, 161 patients who were referred catheter ablation enrolled divided into two groups according to median diameter (≤39 mm: normal group, >39 enlarged group). As a control 22 underwent...
Background Acute decompensated heart failure (ADHF) is a growing healthcare burden with increasing prevalence and comorbidities due to progressive aging society. Accumulating evidence suggest that low skeletal muscle mass has negative impact on clinical outcome in elderly adult population. We sought determine the significance of psoas area as novel index patients ADHF. Methods In this single-center retrospective observational study, we reviewed consecutive 865 participants (65 years or...
Abstract Dipeptidyl-peptidase-4 inhibitors (DPP4i) have been the most used antidiabetic medications worldwide due to their good safety profiles and tolerability with a low risk of hypoglycemia, however, large cardiovascular outcome trials (CVOTs) not shown any significant prognostic superiority. On contrary, since observational studies suggested effects DPP4i are enhanced some populations, such as Asians those who without overweight, benefit is still under debate. The aim this study was thus...
Abstract Background In the secondary prevention of cardiovascular (CV) disease in patients with diabetes, an optimal level HbA1c, most widely-used glycemic control indicator, for favorable clinical consequences still remains to be established. This study assessed association between preprocedural HbA1c and CV mortality Japanese diabetic undergoing percutaneous coronary intervention (PCI). Methods is a retrospective observational using single-center prospective PCI database involving...
Previous studies showed that elevated apolipoprotein A1 (ApoA1) and high-density lipoprotein cholesterol (HDL-C) predicted reduced risk of cardiovascular-related (CV) mortality in patients following percutaneous coronary intervention (PCI). Nevertheless, as the association between ApoA1 cancer this population has been rarely addressed, our study aimed to evaluate prognostic impact on multiple types after PCI. This is a retrospective analysis single-center prospective registry database who...
High-sensitivity C-reactive protein (hs-CRP) is a well known risk factor for the development of cardiovascular disease and cancer. We investigated long-term impact hs-CRP on cancer mortality in patients with stable coronary artery (CAD).
BackgroundSerum levels of lipoprotein (a) [Lp(a)] have been reported as a residual risk marker for adverse events in patients with coronary artery disease (CAD). However, the prognostic impact Lp(a) on long-term clinical outcomes among diabetic statin therapy after percutaneous intervention (PCI) remains unclear.MethodsThe present investigation was single-center, observational, retrospective cohort study. Among consecutive CAD who underwent first PCI our institution from 2000 to 2016, we...
Patients with end-stage renal disease (ESRD) on chronic hemodialysis who are complicated by coronary artery (CAD) at very high risk of cardiovascular (CV) events and mortality. However, the prognostic benefit statins, which is firmly established in general population, still under debate this particular population.As a part prospective single-center percutaneous intervention (PCI) registry database, study included consecutive patients underwent PCI for first time between 2000 2016 (n = 201)....
Accurate outcome prediction following transcatheter aortic valve implantation (TAVI) has gained further importance along with expanding its indication to patients a lower surgical risk. Although previous studies have evaluated the prognostic impacts of gender and atrial fibrillation (AF) in TAVI patients, these two factors rarely been addressed simultaneously. This retrospective observational study based on multicenter registry involved 1088 who underwent between May, 2010 February, 2020 at...
The aim of this study was to investigate the long-term clinical impact residual inflammatory risk (RIR) by evaluating serial high-sensitivity C-reactive protein (hs-CRP) in Asian patients with coronary artery disease (CAD). We evaluated 2032 stable CAD undergoing percutaneous intervention (PCI) hs-CRP measurements (2 measurements, 6-9 months apart) from period 2000 2016. A high-RIR defined as > 0.9 mg/L according median value. Patients were assigned four groups: persistent-high-RIR,...
Pulmonary hypertension (PH) is a common complication of aortic stenosis (AS). Despite the established association between PH and poor outcomes in patients with AS, prognostic implication change after transcatheter valve implantation (TAVI) has been rarely evaluated. This study analyzed prospective multi-center TAVI registry database involving six Japanese centers used transtricuspid pressure gradient (TRPG) obtained by echocardiography to estimate pulmonary artery systolic pressure. The...
Thrombocytopenia is a frequent complication in patients requiring intra-aortic balloon pumping (IABP) counterpulsation. However, its prognostic impact has not been fully addressed. The objective of this study to evaluate the change platelet number during IABP use on prognosis after device removal.This retrospective observational study. Patients intensive cardiac care unit at three Juntendo University hospitals who underwent percutaneous implantation with or without veno-arterial...
Abstract This cross-sectional study enrolled 202 patients with atrial fibrillation (AF) who had undergone catheter ablation and evaluated the association between high-density lipoprotein (HDL) functionality, cholesterol efflux capacity (CEC) of HDL, pathophysiology left structural remodeling. Participants were divided into two groups, based on their volume index (LAVI) (< 34 mL/m 2 , n = 60 vs. LAVI ≥ 142). We quantified three types HDL CECs by presence or absence cyclic-AMP, as entire,...
Abstract Background Because of the significantly increased cardiovascular risk by complicating type 2 diabetes (T2D) in patients with coronary artery disease (CAD), appropriate estimation is crucial T2D following percutaneous intervention (PCI). Nevertheless, there no established biomarker which can precisely predict outcomes this particular population. Although stromal cell derived factor-1α (SDF-1α) has been suggested to play a key role pathogenesis T2D, prognostic impact SDF-1α secondary...
Abstract Background Diabetes and chronic kidney disease (CKD) are frequently complicated each other. While approximately 40% of patients have diabetes among those with CKD, it is the most major (40-50%) clinically important complication diabetic which critically effects on their quality life outcomes. Moreover, numerous previous evidence has indicated adverse prognostic impact by CKD particularly in secondary prevention established coronary artery (CAD). Nevertheless, to date, limited data...
Abstract Background Evidence has indicated the close association between malnutrition or frailty and adverse outcomes in patients with lower extremity arterial disease (LEAD) following endovascular treatment (EVT). We have previously proposed a novel simply calculable nutritional index by using serum levels of triglyceride, total cholesterol body weight (TCBI) which was useful prognostic indicator for several cardiovascular disorders such as coronary artery disease, cardiogenic shock heart...
Introduction: Anemia is known to be associated with mortality in patients after percutaneous coronary intervention (PCI). However, the impact of temporal change anemia on prognosis not fully elucidated. Methods: We prospectively enrolled consecutive 4589 undergoing PCI from January 2000 December 2016. Among them, patients, whose hemoglobin (Hb) level at procedure (baseline) and follow-up angiography (CAG, 6-12 months PCI), were subjected study (n=1832). Patients divided into 4 groups based...