A5030980096- Blood groups and transfusion
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Medicinal Plant Pharmacodynamics Research
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Hepatitis B Virus Studies
- Pregnancy and preeclampsia studies
- Pharmacological Effects of Natural Compounds
- Viral gastroenteritis research and epidemiology
- Ectopic Pregnancy Diagnosis and Management
- Erythrocyte Function and Pathophysiology
- Gut microbiota and health
- Maternal and fetal healthcare
- Natural product bioactivities and synthesis
- Hepatitis C virus research
- Genomics, phytochemicals, and oxidative stress
- Cytomegalovirus and herpesvirus research
- Diabetes and associated disorders
- Rough Sets and Fuzzy Logic
- Natural Language Processing Techniques
- Hemoglobinopathies and Related Disorders
- Environmental Changes in China
University of Electronic Science and Technology of China
2021-2024
Southeast University
2024
Shenzhen Blood Center
2007-2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2015-2024
ZheJiang Institute For Food and Drug Control
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Jishou University
2024
Huazhong Agricultural University
2021-2023
Chengdu Women's and Children's Central Hospital
2019-2022
The Fourth People's Hospital
2022
Abstract IL-37, a new member of the IL-1 cytokine family, is natural inhibitor innate immunity associated with autoimmune diseases. This study was undertaken to evaluate whether IL-37 has antiarthritic effects in patients rheumatoid arthritis (RA) and mice collagen-induced (CIA). In this study, we analyzed expression PBMCs, serum, lymphocytes from RA as well CD4+ T cells polarized under Th1/Th2/Th17 conditions. The role assessed by investigating recombinant human (rh)IL-37 an adenovirus...
In this study, we investigated the effects of Lactobacillus johnsonii on mouse colitis model. The results showed that supernatant L. culture alleviated and remodeled gut microbiota, represented by an increased abundance bacteria producing short-chain fatty acids, leading to concentration propionic acid in intestine. Further studies revealed inhibited activation MAPK signaling pathway polarization M1 macrophages. Macrophage clearance assays confirmed macrophages are indispensable for...
Abstract The natural product icariin (ICA) and its phosphorylated derivatives (pICA) have been shown to outstanding anti‐inflammatory antioxidant properties. This study was explore the protective effects of ICA pICA on intestinal epithelium enterotoxigenic Escherichia coli (ETEC)‐induced piglet diarrhea underlying mechanisms in vivo vitro. ETEC K88 increased pro‐inflammatory cytokine expression, activated oxidative stress inhibited enzyme activity, induced p38 MAPK gene protein disrupted...
Duck viral hepatitis (DVH) is an acute disease of young ducklings with few convenient and effective veterinary drugs to treat. In pathology, present study mainly focused on the immune mechanism, but very studies have concerned role oxidative stress in pathogenesis DVH. To antioxidative hepatoprotective effects icariin its phosphorylated derivative against DVH, we prepared (p-icariin) using sodium trimetaphosphate-sodium tripolyphosphate method. Ducklings were drunk p-icariin after being...
Aim: This study aimed to explore the therapeutic effectiveness of prophylactic internal iliac artery balloon occlusion (IIABO) during cesarean delivery in management patients with pernicious placenta previa (PPP) coexisting accreta (PA).Methods: retrospectively enrolled 83 diagnosed PPP PA our hospital between January 2014 and December 2017. The were divided into group (n = 58, receiving routine section followed IIABO) control 25, alone). general situation, intraoperative conditions,...
Berberine is an alkaloid extracted from medicinal plants such as Coptis chinensis and Phellodendron chinense. It possesses anti-inflammatory, anti-tumour anti-oxidation properties, regulates Glc lipid metabolism. This study explored the mechanisms of protective effects berberine on barrier function inflammatory damage in porcine intestinal epithelial cells (IPEC-J2) induced by LPS. We first evaluated LPS cell viability. IPEC-J2 were treated with 5 μg/ml for 1 h to establish model, 75, 150...
Abstract Despite major advances in HIV testing, ultrasensitive detection of early infection remains challenging, especially for the viral capsid protein p24, which is an virological biomarker HIV-1 infection. Here, To improve p24 patients missed by immunological tests that dominate diagnostics market, we show a click chemistry amplified nanopore (CAN) assay quantitative detection. This strategy achieves 20.8 fM (0.5 pg/ml) limit antigen human serum, demonstrating 20~100-fold higher...
Our previous research showed that icariin (1) and its phosphorylated structural modification (2) improved the survival attenuated oxidative stress liver dysfunction induced by duck virus hepatitis. In this paper, we were one step closer to determine structure of phosphorylation FT-IR, HRESIMS 13C NMR. Anti-DHAV activities 1 2 compared in embryonic hepatocytes (DEHs) cultured vitro artificial infection method vivo. Additionally, antiviral mechanisms replication/release DHAV gene expression...
Icariin (ICA) and phosphorylated icariin (pICA) have excellent antiviral antioxidant effects. However, whether ICA pICA cause anti-LPS-induced intestinal damage remains unclear. In this study, we used Caco-2 cells as a model to investigate the protective effects of on human colonic epithelial explore their potential mechanisms. Our results indicated that increased cell viability decreased lactate dehydrogenase activity in cells. also attenuated LPS-induced changes permeability reduced levels...
This study investigated the effects of icariin on intestinal barrier function and its underlying mechanisms. The diet improved growth rate reduced diarrhea in piglets. also levels plasma colonic IL-1β, -6, -8, TNF-α, MDA but increased activity SOD, GPx, CAT. Besides, endotoxin, DAO, d-lactate, zonulin were markedly groups. Meanwhile, dietary intake significantly gene protein expression ZO-1, Occludin, Claudin-1 colon. Furthermore, expressions TLR4, MyD88, NF-κB inhibited colon fed microbiota...
In this study, we used LS174T cells as a model to investigate the protective effects of icariin and phosphorylated on LPS-induced goblet cell dysfunction. Our results indicated that increased viability decreased lactate dehydrogenase activity in LPS-treated cells. Icariin attenuated changes mucin 2 synthesis secretion. Besides, reduced levels ROS, MDA, H O SOD, GPx, CAT, T-AOC Moreover, IL-1β, IL-6, IL-8, TNF-α were group. Furthermore, gene abundance or enzyme Bip, XBP1, GRP78, CHOP,...
Because polysaccharide and flavone ingredients display good antiviral activity, we developed a flavone/polysaccharide-containing prescription that would be effective against duck viral hepatitis (DVH) investigated its hepatoprotective effects. Flavones were derived from Hypericum japonicum (HJF) (entire herb of Thunb) Salvia plebeia (SPF) R. Br.), polysaccharides Radix Rehmanniae Recens (RRRP) (dried root Rehmannia glutinosa Libosch). This combination was based on the theory syndrome...
The duck virus hepatitis(DVH)caused by the hepatitis A (DHAV) has produced extensive economic losses to industry. currently licensed commercial vaccine shown some defects and does not completely prevent DVH. Accordingly, a new alternative treatment for this disease is urgently needed. Previous studies have that icariin (ICA) its phosphorylated derivative (pICA) possessed good anti-DHAV effects through direct indirect antiviral pathways, such as antioxidative stress. But antioxidant activity...
Duck viral hepatitis (DVH) is an acute disease of young ducklings with no effective veterinary drugs for treatment. Gynostemma pentaphyllum a well-known traditional Chinese medicine that plays important role in the treatment various diseases. Gypenoside (GP), one main ingredients pentaphyllum, was reported good hepatoprotective effects. However, its low solubility limits application clinics. To improve and bioactivity, phosphorylated derivative gypenoside (pGP) prepared by sodium...
Previous studies found that Poria cocos polysaccharides (PCPs) significantly enhanced the antioxidant activity in piglet intestines while increasing abundance of Lactobacillus. However, relationship between Lactobacillus and has yet to be verified, mode action needs further investigation. Six strains isolated from neonatal piglets fed with PCPs were studied investigate intestinal oxidative stress. The results showed three them alleviated stress protected barrier. Subsequently, we extracted...