A5113375986- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Advanced Thermoelectric Materials and Devices
- Advanced Thermodynamics and Statistical Mechanics
- CAR-T cell therapy research
- Catalytic C–H Functionalization Methods
- Integrated Circuits and Semiconductor Failure Analysis
- Malaria Research and Control
- Asymmetric Hydrogenation and Catalysis
- Catalytic Cross-Coupling Reactions
- Silicon Carbide Semiconductor Technologies
- Freezing and Crystallization Processes
- Autophagy in Disease and Therapy
- ATP Synthase and ATPases Research
- Crystallography and molecular interactions
- Quantum, superfluid, helium dynamics
- Tea Polyphenols and Effects
- Nanoplatforms for cancer theranostics
- Innovations in Aquaponics and Hydroponics Systems
- Cancer-related Molecular Pathways
- Liver physiology and pathology
- Pituitary Gland Disorders and Treatments
- Thermal properties of materials
Ministry of Education of the People's Republic of China
2020-2025
Beijing Tongren Hospital
2025
Capital Medical University
2025
Third Affiliated Hospital of Zhengzhou University
2024
Xiamen University
2024
Northeast Electric Power University
2024
Agricultural Genomics Institute at Shenzhen
2023
Chinese Academy of Agricultural Sciences
2023
Qingdao Agricultural University
2023
Zhengzhou University
2014-2022
Autologous chimeric antigen receptor T (CAR-T) cell therapy is an effective treatment for relapsed/refractory acute lymphoblastic leukemia (r/r ALL). However, certain characteristics of autologous CAR-T cells can delay availability. Relapse caused by escape after single-targeted another issue. Therefore, we aim to develop CRISPR-edited universal off-the-shelf CD19/CD22 dual-targeted as a novel r/r ALL.In this open-label dose-escalation phase I study, CD19/CD22-targeting (CTA101) with...
Abstract Purpose Anti‐CD19 chimeric antigen receptor T (CAR‐T) cell therapy has demonstrated remarkable efficacy for refractory and relapsed diffuse large B lymphoma (R/R DLBCL). However, this failed in nearly 25% patients mainly due to loss. The authors performed a phase Ⅱ trial by coadministration of anti‐CD19 anti‐CD20 CAR‐T cells treatment R/R DLBCL evaluated its toxicity. Methods Totally 21 with were enrolled study. conditioned fludarabine cyclophosphamide before the infusion cells....
A series of chiral NCN pincer Pd(II) complexes with 1,3-bis(2′-imidazolinyl)phenyl (Phebim) ligands were synthesized via the C–H activation or oxidative addition method. dinuclear macrocyclic complex was also prepared by reaction Phebim-H ligand PdCl2. All new compounds fully characterized, and X-ray single-crystal structures obtained for two complexes. The successfully applied to enantioselective hydrophosphination various enones diphenylphosphine, providing optically active phosphine...
Flaviviruses including Zika virus, Dengue Japanese Encephalitis and Yellow Fever virus cause heavy burdens to public health around the world. No specific antiviral drug is available in clinic against these flavivirus infections. Heat-shock protein 70 (HSP70) has recently been proven be a promising target virus. Here, we report that Apoptozole, small molecule inhibitor of ATPase activity HSP70, broad-spectrum anti-flavivirus potential. The mode action analysis revealed Apoptozole acted at...
Abstract Zika virus (ZIKV) infection can be the cause of congenital malformations, including microcephaly in infants and other disorders such as Guillain-Barré syndrome, meningoencephalitis, myelitis, which also occur some infected adults. However, at this time, there is no drug approved to treat ZIKV infection. Drug repurposing promptest way obtain an effective during a global public health emergency spread virus. In study, we report US Food Admistration-approved that safe for pediatric...
Epidemics caused by flaviviruses occur globally; however, no antiviral drugs treating infections have yet been developed. Nafamostat (NM) is a protease inhibitor approved for pancreatitis and anti-coagulation. The anti-flavivirus potential of NM has to be determined. Here, utilizing in vitro vivo infection assays, we present that effectively inhibits Zika virus (ZIKV) other vitro. inhibited the production ZIKV viral RNA proteins originating from Asia African lineage human-, mouse-...
Expression of MDM2 protein appears to be increased in malignancy and correlated prognosis tumors, but its role gastric cancer remains controversial. Our recent investigations indicated that JWA was a novel candidate biomarker for cancer. To evaluate the impact expression alone, combination with JWA, on prognostic predictive patients resectable cancer, were examined by immunohistochemistry three large cohorts (total n = 1131) patient We found levels significantly upregulated (70.4%, 57 81)...
This study illustrated the growth of Scenedesmus obliquus and recycle nutrients in wastewater combined with inorganic carbon under autotrophic conditions. was cultivated different conditions by adding sodium carbonate (Na 2 CO 3 ) at 15–40 mg l −1 separately containing high nitrogen phosphorus content. The characteristics S. , pH dissolved (DIC) changes microalgae liquid, rate ammonia lipid content were determined. DIC showed that could use Na to grow, contents 18–25%. Among all...
Hydrogen gas (H2) and glucose (Glc) have been reported as novel antioxidants signal molecules involved in multiple biological processes plants. However, the physiological roles relationships of H2 Glc adventitious rooting are less clear. Here, we showed that effects different concentrations (0, 0.01, 0.05, 0.10, 0.50 1.00 mM) on cucumber were dose-dependent, with a maximal response at 0.10 mM. While, positive hydrogen rich water (HRW, donor)-regulated blocked by specific inhibitor...
A series of new chiral PCN pincer Pd(II) complexes 3a-l with aryl-based (phosphine)-(imidazoline) ligands were conveniently synthesized from readily available starting materials the key step being phosphination/C-H palladation reaction. All characterized by 1H NMR, 13C{1H} 31P{1H} and elemental analysis. In addition, molecular structures 3c, 3e, 3i, 3k have been determined X-ray single crystal diffraction The potential obtained in catalytic enantioselective hydrophosphination reaction was...
SUMMARY During the oolong tea withering process, abiotic stresses induce significant changes in content of various flavor substances and jasmonic acid (JA). However, chromatin accessibility during their potential impact remain poorly understood. By integrating ATAC‐seq, RNA‐seq, metabolite, hormone assays, we characterized treatment‐induced accessibility, gene expression levels, important metabolite contents, JA JA‐ILE contents. Additionally, analyzed effects alterations on changes,...
Abstract The expression of C‐terminal phosphorylated Smad3 (pSmad3C) is down‐regulated with the progression liver disease. Thus, we hypothesized that pSmad3C may be negatively related to To develop novel therapeutic strategies, a suitable animal model required will allow researchers study effect domain‐specific phosphorylation on disease progression. current aimed construct new mouse site mutation and explore effects this CCl 4 ‐induced inflammation. mutant mice were generated using...
RIG-I-like receptors (RLRs)-mitochondrial antiviral signaling protein (MAVS) are crucial for type I interferon (IFN) pathway and innate immune responses triggered by RNA viruses. However, the regulatory molecular mechanisms underlying virus-activated IFN remain incompletely understood. Here, we found that arginine methyltransferase 7 (PRMT7) serves as a negative regulator of interacting with MAVS catalyzing monomethylation 232 (R232me1) in MAVS. virus infection leads to downregulation...
The freezing behavior of liquid water, resulting in solid phases such as glassy structures, hexagonal crystals, or cubic is influenced by surface supercooling. This study identifies three distinct modes water nanodroplets on platinum surfaces through molecular dynamics simulations. At temperatures below 175 K, freeze into a phase characterized structure. Between 176 and 195 nucleation begins within the amorphous solid, crystalline ice formations. In temperature range 196–209 growth occur...
This study aimed to assess whether assisted reproductive technology alters DNA methylation levels at the H19 promoter and imprinting control element (ICE) in fetal tissues obtained after multifetal pregnancy reduction.