A5100720412- Cancer-related molecular mechanisms research
- Heat shock proteins research
- Wnt/β-catenin signaling in development and cancer
- Microtubule and mitosis dynamics
- Colorectal Cancer Surgical Treatments
- Gut microbiota and health
- Mechanisms of cancer metastasis
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Advanced Electron Microscopy Techniques and Applications
- Computational Drug Discovery Methods
- Cardiac Imaging and Diagnostics
- Ferroptosis and cancer prognosis
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Lung Cancer Treatments and Mutations
- Curcumin's Biomedical Applications
- Colorectal Cancer Screening and Detection
- Cell death mechanisms and regulation
- MicroRNA in disease regulation
- Ovarian cancer diagnosis and treatment
- Emergency and Acute Care Studies
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Glycosylation and Glycoproteins Research
China Medical University
2007-2023
First Affiliated Hospital of Soochow University
2015
Soochow University
2015
Observational epidemiological studies suggested an association between the gut microbiota and breast cancer, but it remains unclear whether causally influences risk of cancer. We employed two-sample Mendelian randomization (MR) analysis to investigate this association.We used summary statistics microbiome from a genome-wide study (GWAS) 18,340 individuals in MiBioGen study. GWAS for overall cancer hormone receptor subtype-specific analyses were obtained UK Biobank FinnGen databases, totaling...
Non-small-cell lung cancer (NSCLC) is the leading global cause of cancer-related death. Due to lack reliable diagnostic or prognostic biomarkers, prognosis NSCLC remains poor. Consequently, there an urgent need explore mechanisms underlying this condition in order identify effective biomarkers. G-protein-signaling modulator 2 (GPSM2) widely recognized as a determinant mitotic spindle orientation. However, its role cancer, especially NSCLC, uncertain. In study, we found that GPSM2 was...
Purpose: GPSM2 (G protein signaling modulator 2) was reported to be involved in the cell division of breast cancer cells. Additionally, cytoplasmic dynein may mediate transport process GPSM2. DYNC1I1 (Cytoplasmic 1 intermediate chain 1) is most common cargo-binding subunit dynein. However, relationship between and its clinical value unclear. Methods: Immunohistochemical staining performed for assessment expression. Immunoprecipitation analysis used assess interaction DYNC1I1. Results:...
Tumor necrosis factor receptor-associated protein 1 (TRAP1 or Hsp75) is a member of the mitochondrial heat shock proteins. TRAP1 expression associated with drug and apoptosis resistance in various human cancers. This study assessed tissue specimens epithelial ovarian cancer (EOC) its association clinicopathological features survival EOC patients. Tissue samples from 356 patients were collected for immunohistochemical analysis expression. levels tissues significantly higher than that...
Occludin/ELL domain containing 1 (OCEL1) is a novel discovered protein with its molecular functions remaining unknown and role in lung cancer has not been directly explored.This study focused on the of OCEL1 progression prognosis non-small cell (NSCLC).A public database tissue samples (80 NSCLC paired normal samples) were used to compare differences expression investigate relationship clinical characteristics prognosis.Compared adjacent samples, was significantly down-regulated tumor...