A5101517631- Asymmetric Synthesis and Catalysis
- Vitamin D Research Studies
- Birth, Development, and Health
- Moyamoya disease diagnosis and treatment
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Pancreatic function and diabetes
- Pressure Ulcer Prevention and Management
- Diabetes and associated disorders
- Diabetic Foot Ulcer Assessment and Management
- Axial and Atropisomeric Chirality Synthesis
- Gestational Diabetes Research and Management
- Asymmetric Hydrogenation and Catalysis
- Advanced biosensing and bioanalysis techniques
- Photoreceptor and optogenetics research
- Cancer-related molecular mechanisms research
- Pregnancy and preeclampsia studies
- Eosinophilic Esophagitis
- Genetics and Neurodevelopmental Disorders
- Intracranial Aneurysms: Treatment and Complications
- Supramolecular Chemistry and Complexes
- Wound Healing and Treatments
- Diabetes Treatment and Management
- Bioactive Compounds and Antitumor Agents
- Child Nutrition and Feeding Issues
Guizhou University
2023-2024
Shanghai Children's Medical Center
2019-2024
Shanghai Jiao Tong University
2019-2024
Airport Shunyi District Hospital
2018-2024
Sichuan University
2024
Cangzhou Central Hospital
2016-2024
Zero to Three
2024
Soochow University
2023
Shijiazhuang Tiedao University
2022
Beijing University of Chinese Medicine
2020
A new class of chiral bipyridine-2NO ligands, which incorporate the advantages both bipyridine skeleton and pyrroloimidazolone-based N -oxide moiety, was developed.
The ischaemia-reperfusion (I/R)-induced skin lesion has been identified as primary cause of pressure ulcers. To date, attempts to prevent ulcers have not produced a significant improvement. Quercetin, one the most widely distributed flavonoids in fruits and vegetables, exhibits its antioxidant anti-inflammatory properties against many diseases, including ischaemic heart disease, atherosclerosis renal injury. In vitro wound scratch assay was first used assess function quercetin wounding cell...
Abstract Background: Glioma is the most common malignant tumor in human central nervous system. Long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) promotes oncogenesis various tumors. In present study, we aimed to examine role of NEAT1 altering properties gliomas. Methods: Quantitative real-time PCR technology was used determine expression levels relevant genes tissues and cell lines. The protein were validated by Western blotting. Cell counting kit-8 (CCK-8) colony...
An unprecedented example of skeletal editing pyrrolidines to 1,2-oxazinanes expands the applicability scope “single-atom” skeletal-editing technologies.
Skeletal system toxicity due to lead exposure has attracted extensive attention in recent years, but few studies focus on the skeletal of early life stages zebrafish. The endocrine system, especially GH/IGF-1 axis, plays an important role bone development and health zebrafish life. In present study, we investigated whether acetate (PbAc) affected thereby causing embryos. Zebrafish embryos were exposed PbAc between 2 120 h post fertilization (hpf). At hpf, measured developmental indices, such...
This work diversified the Py-2NO ligand library recently developed by our group and further expanded application of chiral ligands in asymmetric catalysis.
Comprehensive Summary The privileged C 2 ‐symmetric rigid phenol‐type ligand is more attractive but challenging in asymmetric catalysis. Herein, we designed and synthesized a class of rigid‐featured chiral tridentate Phenol‐2NO ligands, that incorporate the advantages both phenol skeleton pyrroloimidazolone‐based N ‐oxide moiety, from readily available L ‐prolinamides operationally simple two steps up to 44% overall yield. More importantly, using an achiral quinoline derivative as additive,...
Abstract Background and Objective As oral food challenge (OFC) cannot be performed routinely in the general outpatient, this study aimed to construct a nomogram predict odds of allergy infants with idiopathic feeding problems malnutrition. Methods From August 2018 December 2021, 289 (median age, 6 months; P25–P75, 4–8) malnutrition were enrolled from seven hospitals Shanghai, China. Food was defined as positive response skin prick test or OFC, gastrointestinal, dermatologic, respiratory...
A new class of C 2 -symmetric rigid-featured chiral phen ligands that provide the N , O -tetradentate coordination moiety and two additional -dioxides were rationally designed developed.
The development of a series novel and easily accessed chiral naphthyridine-type binucleating ligands for asymmetric catalysis.
Biomolecular machines autonomously convert energy into functions, driving systems away from thermodynamic equilibrium. This conversion is achieved by leveraging complex, kinetically asymmetric chemical reaction networks that are challenging to characterize precisely. In contrast, all known synthetic molecular in which kinetic asymmetry has been quantified well described simple single-cycle networks. Here, we report on a unique light-driven [2]rotaxane enables the autonomous operation of...
Abstract To expand the chemical space of chiral N ‐oxides and furan‐containing ligands, herein we designed synthesized a new class rigid‐featured tertiary amine‐derived C 2 ‐symmetric furan‐ , N′ ‐dioxide (Fu‐2NO) ligands from optically pure l ‐prolinamides/hydroxylprolinamides in operationally simple two steps up to 57 % overall yield. The newly developed Fu‐2NO possesses pyrroloimidazolone‐based as non‐flat walls, afforded opportunity for fine‐tuning ligand electronic conformational...
The current study aimed to explore the combined and individual effects of vitamin D (VitD) status in three trimesters during pregnancy cord blood (CB) on child growth trajectories from birth 4 years age. Pregnant women (n = 1100) were recruited between 2013 2016 Shanghai Birth Cohort (SBC) Study. A total 959 mother-child dyads included. VitD was measured by LC-MS/MS at (T1, T2, T3) CB. Children's weight, length/height, head circumference assessed birth, 42 days, 6, 12, 24 months, age,...
Glycogen synthase kinase 3beta (GSK-3beta) represses cell cycle progression by directly phosphorylating cyclin D1 and indirectly regulating transcription inhibiting Wnt signaling. Recently, we reported that the Epm2a-encoded laforin is a GSK-3beta phosphatase tumor suppressor. The cellular mechanism for its suppression remains unknown. Using ex vivo thymocytes primary embryonic fibroblasts from Epm2a(-/-) mice, show here general function of in regulation repression expression. Moreover,...
BackgroundMaturity-onset diabetes of the young (MODY) due to variants hepatocyte nuclear factor 1-beta (HNF1β) (MODY5) has not been well studied in Chinese population. This study aimed estimate its prevalence and evaluate application a clinical screening method (Faguer score) early-onset (EOD) patients. MethodsAmong 679 EOD patients clinically diagnosed with type 2 mellitus (age at diagnosis ≤40 years), exons HNF1β were sequenced. Functional impact rare was evaluated using dual-luciferase...
Human interleukin-24 (IL-24) has been found recently to play a tumor-suppressor role in variety of tumors, including gliomas. However, the exact mechanism glioma tumor suppression by IL-24 remains unclear. We collected surgery 30 gliomas at different grades and evaluated double-stranded RNA-activated protein kinase (PKR) expression using fluorescence quantitative real-time PCR immunohistochemical techniques. Two human cell lines, U87 U251, were transfected with Ad5F35-IL24 via recombinant...
The ischemia-reperfusion (I/R) induced skin lesion has been identified as primary cause of pressure ulcer. Better understanding the mechanism is required for new therapy development. Leucine rich repeat containing protein 19 (LRRC19) a recently discovered transmembrane leucine-rich repeats and plays role in immune response. To investigate LRRC19 ulcers, mouse ulcer model was established with two cycles I/R. expression assessed during injury. siRNA mediated downregulation applied to disease...
1. Wen PY, Kesari S. (2008). Malignant gliomas in adults N Engl J Med. 359: 492-507. Google Scholar
Herein, the first example of umpolung α-regioselective 1,3-dipolar cycloaddition optically pure perhydroindole-2-carboxylic acid 1a with pyridinecarboxaldehydes 2 is described.