A5102887974- Retinal Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Natural Compounds in Disease Treatment
- Autophagy in Disease and Therapy
- Signaling Pathways in Disease
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Disease and Adiposity
- Metabolomics and Mass Spectrometry Studies
- Flavonoids in Medical Research
- Endoplasmic Reticulum Stress and Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Biochemical effects in animals
- Gout, Hyperuricemia, Uric Acid
- Axon Guidance and Neuronal Signaling
- Cardiac Fibrosis and Remodeling
- Biomarkers in Disease Mechanisms
- Engineering Diagnostics and Reliability
- Complement system in diseases
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- MicroRNA in disease regulation
- Acute Kidney Injury Research
- Angiogenesis and VEGF in Cancer
- Heme Oxygenase-1 and Carbon Monoxide
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Gansu Provincial Hospital
2022
Beijing University of Chinese Medicine
2015-2017
Tongluo Yishen (TLYS) decoction is an herb that extensively applied for the treatment of chronic kidney disease (CKD) in traditional Chinese medicine. In this study, 37 different dominant chemical constituents TLYS were identified. Rats with unilateral ureteral obstruction (UUO) used as animal models, and was administered orally 14 days. reduced levels renal function indicators, serum creatinine blood urea nitrogen alleviated pathological changes. Gene Ontology (GO) KEGG pathway analyses RNA...
The Hippo signaling pathway is reported to be involved in angiogenesis, but the roles of diabetic retinopathy have not been addressed. Fufang Xueshuantong Capsule has used treat China; however, effect on investigated. In this study, diabetes was induced Sprague-Dawley rats with intraperitoneal injection streptozotocin. Twenty weeks later, administered for 12 weeks. When administration ended, eyes were isolated western blot and immunohistochemistry analyses. levels P- mammalian sterile...
Diabetic cardiomyopathy (DCM) is one of the main complications diabetic patients and major reason for high prevalence heart failure in patients. Fufang Xueshuantong (FXST) a traditional Chinese medicine formula commonly used treatment retinopathy stable angina pectoris. However, role FXST DCM has not yet been clarified. This study was conducted to investigate effects on myocardial lesions reveal its molecular mechanism. The rats were intraperitoneally injected with 65 mg/kg streptozotocin...
Purpose: In this study, we investigated the mechanism of Tongluo Yishen (TLYS) decoction in more detail, from perspective pyroptosis unilateral ureteral ligation (UUO) model and hypoxia-induced renal tubular epithelial (NRK-52E) cell. Method: The UUO was used, after 14 days TLYS intervention, rats were tested for blood creatinine urea nitrogen, HE staining used to observe pathological changes kidney, Masson assess degree interstitial fibrosis, western blot detect α-smooth muscle actin...
Introduction With the increasing prevalence of hypertension, incidence kidney diseases is also increasing, resulting in a serious public burden. Jiangya Tongluo decoction (JYTL), recognized prescription traditional Chinese medicine (TCM), commonly used to calm an overactive liver and reduce excess yang, while promoting blood flow alleviate obstructions meridians. Previous research has indicated that JYTL may help mitigate damage caused by hypertension; however, underlying mechanisms have not...
Objective: To explore the relationship between coronary tortuosity and microvascular disease (CMVD). Methods: Patients with typical angina symptoms without serious artery stenosis by angiography were enrolled from June 2014 to December 2016, CMVD was diagnosed single photon emission tomography (SPECT). According SPECT results, patients divided group non-CMVD group. The baseline clinical characteristics, results of compared two groups. logistic analysis used analyze CMVD. Result: A total 117...