A5080312749- Genetics, Aging, and Longevity in Model Organisms
- Neurological Disease Mechanisms and Treatments
- Bioactive natural compounds
- Retinal Diseases and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Flavonoids in Medical Research
- Hepatitis C virus research
- Complement system in diseases
- Chemical synthesis and alkaloids
- Bioactive Compounds and Antitumor Agents
- Autophagy in Disease and Therapy
- Natural product bioactivities and synthesis
- Fungal Biology and Applications
- Cancer Mechanisms and Therapy
- Hepatitis B Virus Studies
- Herbal Medicine Research Studies
- Bioactive Compounds in Plants
- Synthesis and bioactivity of alkaloids
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Retinoids in leukemia and cellular processes
- Cholinesterase and Neurodegenerative Diseases
Beijing University of Chinese Medicine
2020-2022
Gastric cancer (GC) is one of the most common malignancies and has second highest lethal rate in world; thus, finding new medicines with high potency low toxicity urgent. Cudrania tricuspidata (Carr.) Bur. ex Lavallee (Moraceae) a traditional medicinal herb that considered to have antitumour efficacy. We extracted isolated cudraxanthone L (CXL) from evaluated its anti-cancer CXL treatment inhibited angiogenesis chorioallantoic membrane (CAM) repressed cell viability various human cells,...
Objective To explore the influence of fenofibrate on diabetic retinopathy (DR) in rats via sirtuin1 (SIRT1)/nuclear factor-κB (NF-κB) signaling pathway. Patients and methods A total 30 SD were divided into group (DR group), B (fenofibrate treatment group) C (Healthy group). Rats intraperitoneally injected with 50 mg/kg streptozotocin (STZ) for 5 days without feeding. After fasting 2 days, blood was drawn from tail veins to measure glucose, glucose ≥16.7 mmol/L represented that model...
Purpose: Pinocembrin is a dihydroflavonoid, which widely found in several plant species. Although pinocembrin has good pharmacological activity, it poor water solubility and low bioavailability. Therefore, we have modified the structure of with combination different amino acids to solve this problem. Moreover, effect antiaging activity them not been explored. We aim investigate its acid derivatives on aging Caenorhabditis elegans . Methods: was spliced order obtain their corresponding...
N-Alkylamides (NAAs), derived from Anacyclus pyrethrum (L.) DC, have potential anti-tumor effects. To explore the molecular mechanism and chemo-preventive capacity of NAAs, we synthesized an NAA (H-10) evaluated whether it could inhibit proliferation B16, HepG2, HeLa, HCT116 cancer cells in 2D culture. evaluate antiproliferative activity H-10 3D culture BD, cells, multicellular tumor spheroids were constructed to more accurately reflect cell environment. visualize nuclear changes related...
Background: Total flavonoid of Cudrania tricuspidata (TFC), an effective component tricuspidata, has been proved to have various pharmacological activities. According ancient records, effect on improving eyesight. There are plenty pathway associted with diabetic retinooathy and oxidative damage pathawy is essential one them. Objective: In this research, the mechanism TFC STZ mice nematodes were investigated firstly.Methods: Different elution condition macroporous resin compared get optimum...