A5024767670- Intracranial Aneurysms: Treatment and Complications
- Moyamoya disease diagnosis and treatment
- Vascular Malformations Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Hematomas and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Neurological Complications and Syndromes
- Nanoparticle-Based Drug Delivery
- Extracellular vesicles in disease
- Trigeminal Neuralgia and Treatments
- Nuclear Receptors and Signaling
- Botulinum Toxin and Related Neurological Disorders
- Circular RNAs in diseases
- Adrenal and Paraganglionic Tumors
- Virus-based gene therapy research
- interferon and immune responses
- Pharmacological Effects of Natural Compounds
- Nanoplatforms for cancer theranostics
- RNA regulation and disease
- Angiogenesis and VEGF in Cancer
- Advanced biosensing and bioanalysis techniques
Cangzhou Central Hospital
2015-2024
People's Hospital of Cangzhou
2016
Chronic subdural hematoma (CSDH) is a trauma-associated condition commonly found in elderly patients. Surgery currently the treatment of choice, but it carries significant risk recurrence and death. Nonsurgical treatments remain limited ineffective. Our recent studies suggest that atorvastatin reduces hematomas improves clinical outcomes patients with CSDH.To investigate safety therapeutic efficacy to nonsurgically treat CSDH.The Effect Atorvastatin on Subdural Hematoma (ATOCH) randomized,...
Background Glioma is one of the most wide-spreading brain cancers worldwide. Exosomes have emerged as essential regulators in intercellular communication, and exosomal circular RNAs (circRNAs) are critical for cancer progression. In this study, we aimed to investigate role circRNAs glioma progression associated mechanisms. Methods derived from cells were isolated identified by transmission electron microscopy nanoparticle tracking analysis (NTA). CCK-8, wound healing assays, transwell...
Human interleukin-24 (IL-24) has been found recently to play a tumor-suppressor role in variety of tumors, including gliomas. However, the exact mechanism glioma tumor suppression by IL-24 remains unclear. We collected surgery 30 gliomas at different grades and evaluated double-stranded RNA-activated protein kinase (PKR) expression using fluorescence quantitative real-time PCR immunohistochemical techniques. Two human cell lines, U87 U251, were transfected with Ad5F35-IL24 via recombinant...
To investigate the efficiency of capecitabine (CAP) plus temozolomide (TEM) in refractory pituitary adenoma after tumor resection and its impact on serum prolactin (PRL), insulin-like growth factor 1 (IGF-1), hormone (GH) levels.From January 2017 to 2020, 80 patients assessed for eligibility receiving transsphenoidal Department Neurosurgery our hospital were recruited. They randomly distributed at a ratio : via random number table method receive either bromocriptine TEM (control group) or...
To study the changes of motor and cognitive function pituitary tumor rats after operation. Methods: The experiment was divided into three groups: control group, model group operation (30 animals for each group). Female Fischer344 were selected. Model subcutaneously embedded with 10 mg estrogen sustained-release pump to induce a model, normal saline as control. successfully treated by microsurgery established. quantitative expressions PTTG, FGF-2 VEGF detected Western blot. Morris test used...
ABSTRACT Objective The study evaluated the effectiveness and safety of single‐stage versus multistage endovascular treatment in subarachnoid hemorrhage patients with Mirror Aneurysms. Materials Methods Our research team performed a prospective study, focusing on radiographic clinical data diagnosed hemorrhage, specifically those who presented Aneurysms upon admission to our institutions. According different stages, these were grouped into cohort cohort. Result A total 216 aneurysms...
Background: Normobaric hyperoxia (NBH) and hyperbaric oxygen therapy (HBOT) are effective treatment plan for traumatic brain injury (TBI). The aim of this study was to compare cognitive outcome after mild TBI between NBH HBOT so as provide a more suitable strategy patients with TBI. Methods: A prospective research conducted October 2017 March 2023, enrolling (Glasgow coma scale score: 13–15 points) within 24 hours in Cangzhou Central Hospital. Patients were randomized into 3 groups: group...
Objective To investigate the efficacy and prognosis of hemifacial spasm microvascular decompression. Methods The clinical data 833 patients with treated decompression at Department Neurosurgery, Cangzhou Central Hospital, Hebei Province from January 2004 to 2012 were analyzed retrospectively. According recovery after surgery, they divided into 4 groups: instantly cure, delayed recurrent, unhealed. The groups statistically. Results Of underwent decompression, 472 cured instantly,...
Moyamoya disease (MMD) is currently thought to involve endothelial progenitor cells (EPCs). We investigated whether superparamagnetic iron oxide (SPIO) can be used label EPCs. Mononuclear from 10 moyamoya patients were isolated, and cluster of differentiation 133 (CD133) positive sorted by magnetic-activated cell sorting cultured in vitro. The rates CD133, vascular growth factor receptor (VEGFR)-2, 34 (CD34) detected flow cytometry. co-cultured with fluorescence labeled...
In this work, we synthesized folate-conjugated dual-drug loaded double liposomes which are noted for their extremely high target specificity towards pituitary adenomas. It is known that while folate receptors almost non-existent in normal tissues, they overexpressed non-functional Synthesis, characterization and vitro studies of targeting adenomas the highlight study. The size, zeta-potential, polydispersity index, release studies, stability nanoformulation, cytotoxicity cellular uptake have...