A5111358233- Vitamin D Research Studies
- Birth, Development, and Health
- Congenital Heart Disease Studies
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Per- and polyfluoroalkyl substances research
- Cardiac Structural Anomalies and Repair
- Gestational Diabetes Research and Management
- Air Quality and Health Impacts
- Anesthesia and Neurotoxicity Research
- Heavy metals in environment
- Reproductive System and Pregnancy
- Coronary Artery Anomalies
- Congenital heart defects research
- Calcium signaling and nucleotide metabolism
- Climate Change and Health Impacts
- Biotin and Related Studies
- Adenosine and Purinergic Signaling
- Sperm and Testicular Function
- Aortic aneurysm repair treatments
- Mercury impact and mitigation studies
- Body Composition Measurement Techniques
- Tracheal and airway disorders
XinHua Hospital
2012-2025
Shanghai Jiao Tong University
2011-2025
Guangdong Medical College
2024
Shanghai Children's Medical Center
2018-2022
Background Semen quality is negatively correlated with male age and mainly quantified by a routine semen analysis, which descriptive inconclusive. Sperm proteins or metabolites are used as the intermediate end-products, reflecting changes in quality, hold much promise new biomarker to predict fertility advanced-aged males. Objectives In this study, we sought assess whether metabolome proteome of aged males can affect serve biomarkers for predicting quality. Materials methods We...
<title>Abstract</title> <bold>Background: </bold>Obesity and aging are regarded as significant risk factors for type 2 diabetes(T2D). However, joint effect of body roundness index (BRI) age acceleration (ACC), novel predictors visceral the rate aging, with incident T2D remains unclear. <bold>Objective: </bold>To examine associations BRI ACC T2D. <bold>Methods: </bold>This prospective cohort study used data from UK Biobank, participants pre-existing diabetes missing were excluded in analysis....
Aims To evaluate the prevalence and risk factors of elevated blood lead levels (EBLL) among pediatric population in China. Methods Questionnaire investigation about Lead exposure information, venous samples collection BLL detection are conducted. A total 32,543 subjects aged 0–6 years old (from 1 month to under 7 old) were recruited from May 2013 March 2015 15 provinces Results The overall weighted EBLL which is defined as ≥ 50 μg/L this study 4.1%, for different geographical regions, with...
Objectives Invasive Non-typhoidal Salmonella (iNTS) can cause serious, life-threatening, and invasive infections, posing great challenges to public health. We aimed systematically review the burden of iNTS disease based on Global Burden Diseases (GBD) 2021. Methods extracted data for incidence, death, disability-adjusted life-years (DALYs) associated with from GBD 2021, providing an overview its epidemiology while examining trends 1990 Additionally, we decomposed changes iNTS-related burden,...
<title>Abstract</title> <bold>Backgroud</bold> Postoperative infections are a major complication in pediatric congenital heart disease (CHD) patients, leading to prolonged ICU stays, increased mechanical ventilation time, and extended hospitalization. This study aims investigate the prevalence, clinical outcomes, associated risk factors for postoperative CHD patients.<bold>Methods</bold> retrospective included 1,131 patients who underwent surgery at Xinhua Hospital Affiliated Shanghai Jiao...
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, with a prevalence 6-8%. Although etiology PCOS has been investigated extensively, association between genetic predisposition and risk largely unknown. In this study, we genotyped 63 SNPs 10 genes among 361 patients 331 healthy controls Chinese Han population. The following variant alleles were significantly associated decreased risk: ESR1 rs9340799 (P = 0.000), PPARG rs709154 0.013), rs1151996...
Exposure of females to fine particulate matter ≤2.5 μm in diameter (PM2.5) prior pregnancy could produce adverse impact on fertility and enhances susceptibility the offspring a variety diseases. In current study, female C57BL/6 mice (6 weeks age) were exposed either concentrated PM2.5 or filtered air (average concentration: 115.60 ± 7.77 vs. 14.07 0.38 μg/m−3) using whole-body exposure device for 12 weeks. Briefly, decreased anti-Müllerian hormone level (613.40 17.36 vs 759.30 21.90 pg mL−1,...
Congenital ventricular aneurysms or diverticulum (VA/VD) are rare cardiac anomalies with lack prenatal evaluation data. The present study aimed to provide the characteristics and outcomes from a tertiary center use of new techniques evaluate shape contractility these fetuses.Ten fetuses were diagnosed VA VD, 30 control enrolled. Fetal echocardiography was performed make diagnosis. echo follow-up data carefully reviewed. measurements four-chamber view (4CV) both ventricles measured computed...
The current study aimed to explore the combined and individual effects of vitamin D (VitD) status in three trimesters during pregnancy cord blood (CB) on child growth trajectories from birth 4 years age. Pregnant women (n = 1100) were recruited between 2013 2016 Shanghai Birth Cohort (SBC) Study. A total 959 mother-child dyads included. VitD was measured by LC-MS/MS at (T1, T2, T3) CB. Children's weight, length/height, head circumference assessed birth, 42 days, 6, 12, 24 months, age,...
Total anomalous pulmonary venous connection (TAPVC) is a rare congenital heart anomaly. Several genes have been associated TAPVC but the mechanisms remain elusive. To search novel CNVs and candidate genes, we screened cohort of 78 cases 100 healthy controls for copy number variants (CNVs) using whole exome sequencing (WES). Then identified pathogenic by statistical comparisons between case control groups. After that, altogether eight seven (PCSK7, RRP7A, SERHL, TARP, TTN, SERHL2, NBPF3). All...
Embryo selection in vitro fertilization–embryo transfer (IVF-ET) mostly relies on morphological assessment using a conventional microscope or the time-lapse monitoring system, which is not comprehensive. Inappropriate levels of reactive oxygen species (ROS) fertilization medium may cause damage to gametes, eventually leading adverse IVF outcomes. The present study aimed identify optimal oxidation–reduction level for outcomes by measuring static potential (sORP) highly accurate and sensitive...
Abstract Background: Intrauterine valvuloplasty is an innovative therapy, which promotes ventricular growth and function in some congenital heart diseases (CHDs). The technique remains challenging can only be performed a few centers. This study aimed to assess the feasibility mid-term outcomes of fetal cardiac intervention (FCI) fetuses with critical CHD experienced tertiary center. Methods: Five aortic (FAV) or pulmonary (FPV) procedures were our center between August 2018 May 2022....
Abstract Background Measurement of 25‐hydroxyvitamin D [25(OH)D)] levels is important. The current method requires a relatively large volume serum. To minimize the amount serum needed, we established high‐performance liquid chromatography‐tandem mass spectrometry (HPLC‐MS/MS) to measure 25(OH)D in capillary Methods Venous blood and fingertip were collected from 90 participants. Volumes 100 µL venous 20 collected. samples pretreated by protein removal, extraction concentration, an HPLC‐MS/MS...
This study aimed to investigate whether 25-hydroxyvitamin D (25(OH)D) concentrations are correlated overweight/obesity in infants and explore a threshold of 25(OH)D. A total 1205 six-month-old from two community hospitals Shanghai were randomly recruited, 925 them followed up at 12 months. Concentration 25(OH)D, weight, length measured time points. Overweight/obesity was defined as weight-for-length Z-score >97th percentile. The prevalence 6 months 6.88% 5.26%, respectively. occurrence...