A5056637832- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Airway Management and Intubation Techniques
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- Spine and Intervertebral Disc Pathology
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Congenital Heart Disease Studies
- Tracheal and airway disorders
- Cardiac pacing and defibrillation studies
- Aortic Disease and Treatment Approaches
- Cardiac Arrest and Resuscitation
- Cardiovascular Issues in Pregnancy
- Food Allergy and Anaphylaxis Research
- Sepsis Diagnosis and Treatment
- Contact Dermatitis and Allergies
- Drug-Induced Adverse Reactions
- Heart Rate Variability and Autonomic Control
- Anesthesia and Neurotoxicity Research
- Cardiovascular Function and Risk Factors
Children's Hospital of Philadelphia
2024-2025
Manchester Royal Infirmary
2006-2024
Manchester University NHS Foundation Trust
2018-2024
University of Manchester
2014-2024
Manchester Academic Health Science Centre
2017-2024
Washington University in St. Louis
2023
University of Chicago
2018
Cardiovascular Research Center
1992-2017
Wythenshawe Hospital
2007
In-Q-Tel
2006
Abstract Background The α 2 -adrenoreceptor agonist dexmedetomidine is known to provide renoprotection against ischemia and reperfusion (I/R) injury. However the underlying molecular mechanisms remain unclear. purpose of this study was investigate whether Janus kinase signal transducer activator transcription (JAK/STAT) signaling pathway plays a role in dexmedetomidine’s renoprotection. Methods I/R model induced by bilateral renal pedicle clamping for 45 min followed 48 h male Wistar rat....
Summary A controlled randomised double‐blind design was used to study the effect of lignocaine on pain produced by intravenous injection propofol. Patients received a 2‐ml pretreatment solution with temporary venous occlusion, followed an induction solution. One hundred and three patients were assigned one five groups: saline pretreatment, propofol plus 2 ml; 20 mg 40 mg; or mg. Pain reduced significantly in all groups which dose more effective than There no significant differences incidence...
Objective To compare the frequency of acute stress ulceration and secondary pneumonia caused by aerobic Gram-negative bacilli in ICU patients treated with either sucralfate or ranitidine. Design Prospective, randomized study. Setting ICU, university hospital. Patients Sixty adult who were mechanically ventilated at risk developing ulceration. Intervention The to receive (1 g every 6 hrs) via nasogastric tube iv ranitidine (50 mg hrs). If gastric pH was <3.5 latter group, 30 mL 0.3M sodium...
Severe acute kidney injury (AKI) portends poor outcomes in pediatric sepsis. We evaluated the trajectory and prognostic utility of AKI biomarkers septic shock using a subset participants ongoing Pragmatic Pediatric Trial Balanced vs. Normal Saline Fluid Sepsis (PRoMPT BOLUS) trial, NCT04102371. tested whether fluid volume is associated with persistent elevation urine neutrophil gelatinase-associated lipocalin (Ur-NGAL). Prospective, non-prespecified cohort study within PRoMPT BOLUS trial....
To compare the frequency of stress erosions and ulcers in critically ill adult patients treated with either sucralfate or placebo.Prospective, randomized study.Intensive care unit a university hospital.Twenty-six patients. All were mechanically ventilated at risk developing ulceration.Patients to receive (2 g every 8 hrs) (group 1) via nasogastric tube (flushed 10 mL sterile water) 20 water hrs 2) tube.At time intensive admission, (acute) (as assessed endoscope) was 21.7%. No detected. By...
Summary Twenty healthy volunteers were placed in four different surgical prone positions: on pillows, an evacuatable mattress, pelvic props and the knee—chest position. The normal supine position was used as a control for measurement of cardiovascular parameters. Mean arterial pressure measured by automated oscillotonometry. Transthoracic electrical bioimpedance to measure cardiac output heart rate. Cardiac index total vascular resistance derived from these data. No significant changes rate...
Diabetic retinopathy is the leading cause of blindness in industrialized world. Hyperglycaemia induces retinal hypoxia that upregulates a range vasoactive factors which may lead to macular oedema and/or angiogenesis and hence potentially sight threatening retinopathy. In this study, we have focused on association CD105 vascular endothelial growth factor (VEGF) with development progression diabetic by means quantifying their expression plasma vitreous patients. levels were quantified 38 type...
We have prospectively assessed the effects of remifentanil on morphine requirement in first hour after emerging from general anaesthesia elective coronary artery bypass surgery and 12 h postoperatively, pain agitation scores anaesthesia.Twenty patients undergoing off-pump surgery, receiving standardized propofol-fentanyl-based anaesthesia, randomly received infusions either 0.1 microg kg(-1) min(-1) (Group R, n=10) or saline S, n=10), each infused at 0.12 ml h(-1). Propofol trial drug...
To investigate the haemodynamic effects of varying angle head up tilt.20 healthy subjects (12 female, eight male; mean (SD) age 33.6 (8.4) years) underwent tilt for five minutes to each four angles in random order, with a minute rest period at horizontal between angle. Forearm blood flow was measured using intermittent occlusion mercury strain gauge plethysmography two and minutes. Subjects continuous monitoring heart rate, systolic pressure (SBP), diastolic (DBP) by Finapres cardiac output...
Purkinje fibers (PFs) control timing of ventricular conduction and play a key role in arrhythmogenesis heart failure (HF) patients. We investigated the effects HF on PFs.Echocardiography, electrocardiography, micro-computed tomography, quantitative polymerase chain reaction, immunohistochemistry, volume electron microscopy, sharp microelectrode electrophysiology were used.Congestive was induced rabbits by left volume- pressure-overload producing hypertrophy, diminished fractional shortening...
Thoracic epidural analgesia appears to improve the outcome of patients undergoing coronary artery bypass graft surgery. Cranial extension nerve blockade involving third, fourth and fifth cervical roots can cause apnoea. However, progressive paraesthesia weakness due cephalad spread thoracic will affect arms before diaphragm. A scale was designed test three active movements bilaterally: hand grip (T1/C8), wrist flexion (C8/7) elbow (C6/5). This scoring for arm (ESSAM) consists four grades...
An electrical storm (ES) refers to multiple occurrences of ventricular arrhythmias within a short time. Catheter ablation is treatment option for ES but can be challenging in unstable cardiovascular patients. We present the case 50-year-old patient with poor left function who experienced after emergency coronary artery bypass grafting (CABG). Despite maximal antiarrhythmic therapy, had recurrent tachycardia and fibrillation (VT/VF), hindering catheter ablation. Elective venoarterial...
The sinoatrial/sinus node (SAN) is the primary pacemaker of heart. In humans, SAN surrounded by paranodal area (PNA). Although PNA function remains debated, it thought to act as a subsidiary atrial (SAP) tissue and become dominant in setting sinus disease (SND). Large animal models SND allow characterization SAP, which might be target for novel treatment strategies diseases.A goat model was developed (n = 10) epicardially ablating validated mapping emergent SAP locations through an ablation...
Core Topics in Cardiac Anaesthesia: J. M. Mackay, E. Arrowsmith (eds). Greenwich Medical Media Ltd.: London, 2004, 388 pp; indexed, illustrated, ISBN: 0521868416; Price £45.00 The editors have aimed this book at anaesthetic trainees their first 3–6 months of training cardiac anaesthesia and intensive care. This 367-page consists 66, three- to six-page, topics grouped into 11 sections. sections are anatomy physiology, pharmacology, diagnosis disease, surgery for anaesthetists, monitoring,...
ABSTRACT Introduction: Anaphylaxis is a rare but serious and potentially fatal complication of anesthesia. Little known about the incidence outcome anaphylaxis in cardiac surgical patients, which we aimed to investigate. Methods: This was 21-year retrospective study patients at Manchester Royal Infirmary, Foundation Trust, Manchester, UK. Results: A total 19 cases were reported among 17,589 (0.108%) undergoing surgery. The majority (15/19) occurred before cardiopulmonary bypass (CPB), mostly...
Abstract Canavan disease (CD) is a neurodegenerative disorder caused by biallelic disease-causing variants in the ASPA gene. Here, we utilized long-read sequencing (LRS) to investigate eight individuals clinically diagnosed with but without definitive genetic diagnoses. Our analyses identified recurring previously unreported intronic SVA_E retrotransposon insertion within all individuals. Surprisingly, frequency of this variant population databases suggests it most common pathogenic and...