A5037175236- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Venous Thromboembolism Diagnosis and Management
- Central Venous Catheters and Hemodialysis
- Cardiovascular Effects of Exercise
- Atomic and Subatomic Physics Research
- EEG and Brain-Computer Interfaces
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Fibrosis and Remodeling
- Oral microbiology and periodontitis research
- Connexins and lens biology
- Non-Invasive Vital Sign Monitoring
- Cardiomyopathy and Myosin Studies
- Gut microbiota and health
- Neuroscience and Neuropharmacology Research
- Vascular Procedures and Complications
- Salivary Gland Disorders and Functions
Liverpool Heart and Chest Hospital
2018-2024
University of Liverpool
2018-2024
Liverpool John Moores University
2024
Hungarian School Sport Federation
2023
University of Manchester
2012-2021
Manchester Academic Health Science Centre
2021
Liverpool Heart and Chest Hospital NHS Trust
2020
Manchester University NHS Foundation Trust
2011
BackgroundNo study has assessed durability of pulmonary vein isolation (PVI) with radiofrequency (RF) and Cryoballoon (CB) in patients persistent AF. These data are especially lacking for those significantly diseased left atria (LA).ObjectiveTo assess PVI significant LA disease compare reconnection rates between RF CB.Methods44 Patients (mean age 63, 77% male, median time since AF diagnosis 22.5 months, indexed volume 36 ml/m2) were randomised 1:1 to (StablePoint catheter, Boston Scientific)...
Chlorine has a strong antibacterial property and is the disinfectant most frequently used in swimming pools. Therefore, microbiota community oral cavity of those who practice water sports assumed to be special due their regular immersion water. Adverse changes composition may have serious health consequences. We aimed compare microbiome between polo players non-athletes. hypothesized that differed non-athletes.Altogether, 124 (62 males 62 females, aged 9 20 years) 16 non-athlete youths...
Abstract Background Pulmonary vein isolation (PVI) is the cornerstone of atrial fibrillation (AF) ablation. Despite promising success rates, redo ablation sometimes required. At redo, PVs may be found to isolated (silent) or reconnected. We studied patients with silent vs reconnected at and analysed associations adverse outcomes. Methods Patients undergoing AF ablations between 2013 2019 our institution were included stratified into PVs. The primary outcome was a composite further ablation,...
Abstract Background Patients who have recurrent atrial fibrillation (AF) following redo catheter ablation may eventually be managed with a pace‐and‐ablate approach, involving pacemaker implant followed by atrioventricular nodal (AVNA). We sought to determine which factors would predict subsequent AVNA in patients undergoing AF ablation. Methods analyzed ablations between 2013 and 2019 at our institution. Follow‐up was censored on December 31, 2021. no available follow‐up data were excluded....
The sinoatrial/sinus node (SAN) is the primary pacemaker of heart. In humans, SAN surrounded by paranodal area (PNA). Although PNA function remains debated, it thought to act as a subsidiary atrial (SAP) tissue and become dominant in setting sinus disease (SND). Large animal models SND allow characterization SAP, which might be target for novel treatment strategies diseases.A goat model was developed (n = 10) epicardially ablating validated mapping emergent SAP locations through an ablation...
Atrial fibrillation (AF) ablation services were significantly affected by the COVID-19 pandemic. We aimed to evaluate a symptom-based clinician prioritisation scheme for waiting list management compared with patient-completed quality of life (QoL) scores. also sought understand factors influencing QoL, particularly impact COVID-19, on patients awaiting AF ablation, via bespoke questionnaire.Patients sent two QoL questionnaires (Atrial Fibrillation Effect QualiTy Life (AFEQT) and EuroQol 5D...
Abstract Background and aims Methods for femoral venous haemostasis following electrophysiology (EP) procedures include manual compression (MC) suture‐based techniques such as a figure‐of‐eight suture secured with hand‐tied knot (Fo8 HT ) or modified 3‐way stopcock MOD ). We hypothesised that short‐term bleeding outcomes using the Fo8 approach would be superior to MC. additionally compared between approaches. studied consecutive patients undergoing EP at our institution March December 2023....
<h3>Introduction</h3> In patients with advanced persistent atrial fibrillation the optimal ablation strategy during redo procedures is unknown. The utility of posterior wall isolation (PWI) in addition to pulmonary vein (PVI) these remains uncertain. <h3>Methods</h3> 44 PeAF or longstanding (mean age 63 ± 7.9 years, 77% male, median time since AF diagnosis 22.5 months, indexed LA volume 36 ml/m2) were randomised index radiofrequency PVI followed by protocol mandated at 2 months including PWI...
Abstract Funding Acknowledgements Type of funding sources: Private grant(s) and/or Sponsorship. Main source(s): BioSense Webster Investigator Initiated Study (IIS) Grant. Introduction The COVID-19 pandemic enforced long-term changes in healthcare towards remote working, implementing digital systems that support the safe online sharing clinical information. A cloud-based storage and analysis software has been developed uploads 3D mapping cases within CARTO-3 system for review. In addition, it...
<h3>Introduction</h3> Sinus node (SN) dysfunction is a common clinical condition. When the sinus fails, there are subsidiary atrial pacemakers (SAP) that can take over as leading pacemaker. In goat heart, we compared structures of SAP and SN. <h3>Methods</h3> Adult female goats (n = 8) underwent either epicardial SN ablation 4) sufficient to cause ~50% fall in heart rate or had sham operation 4). The site earliest activation these hearts was localised after 4 weeks using <i>in vivo</i>...
<h3>Introduction</h3> The development of sinus node dysfunction in patients may be accompanied by the emergence subsidiary atrial pacemakers (SAPs) and/or junctional escape rhythms. It has been postulated that biological modification SAPs provide a potential alternative to implantation artificial for treatment disease (“biological pacemakers”). We investigated structural and functional characteristics chronic goat model. <h3>Methods</h3> Adult female goats (n=7) underwent epicardial...
Introduction: The inferior nodal extension (INE), compact node (CN) and penetrating/His bundle (PB/HB) form the atrioventricular (AV) conduction axis are responsible for delay of action potential from atria to ventricles. With ageing, dysfunction AV results in prolongation PR interval block. Methods: We have compared INE, CN PB/HB male rats 3 months old (n 9) 2 years 8). From survival curves, month rat correspond 20 yearr human, whereas year 70 human. Morphological characteristics these...
<h3>Introduction</h3> Following National Service Framework guidance on the management of sudden cardiac death (SCD), regional inherited conditions clinics were established to identify and treat those at increased risk dying from an arrhythmic condition. Studies have examined yield different diagnostic strategies but outcome in these patients has not been reported. <h3>Methods</h3> We present data 193 consecutive (108 families) referred a clinic because SCD/aborted arrest relative. The mean...
<h3>Introduction</h3> The inferior nodal extension (INE), compact atrioventricular (AV) node and penetrating/His bundle (PB) form the AV conduction axis are responsible for delay propagation of action potential from atria to ventricles. With ageing, dysfunction in these tissues results prolongation PR interval first, second third degree block. only treatment is implantation permanent pacemakers, which known be associated with various complications. Previous studies have described age-related...
<h3>Introduction</h3> A 'Pace & Ablate' strategy may be required after failed catheter ablation for atrial fibrillation (AF). We sought to determine which factors predict the requirement Pace Ablate following redo ablation. <h3>Methods</h3> analysed cases from our institutional dataset of AF ablations performed between 2013 and 2019. Patients who underwent ≥1 procedure were included, data most recent analysed. Follow-up was determined using electronic records censored at 31st December...