A5008155203- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Cardiovascular Function and Risk Factors
- Heart rate and cardiovascular health
- Rheumatoid Arthritis Research and Therapies
- Cardiovascular Effects of Exercise
- Systemic Lupus Erythematosus Research
- Cardiac Ischemia and Reperfusion
- Cardiac Fibrosis and Remodeling
- Cardiomyopathy and Myosin Studies
- Heart Rate Variability and Autonomic Control
- Monoclonal and Polyclonal Antibodies Research
- Pulmonary Hypertension Research and Treatments
- Cardiac pacing and defibrillation studies
- Signaling Pathways in Disease
- Iron Metabolism and Disorders
- Pediatric health and respiratory diseases
- Acute Lymphoblastic Leukemia research
- Immune Cell Function and Interaction
- Neuroscience and Neuropharmacology Research
- Liver Diseases and Immunity
- Erythropoietin and Anemia Treatment
- Cardiac Arrhythmias and Treatments
- Systemic Sclerosis and Related Diseases
- Hemoglobinopathies and Related Disorders
Postgraduate School of Molecular Medicine
2015-2024
Centrum Medyczne Kształcenia Podyplomowego
2003-2023
Institute of Biochemistry and Biophysics, Polish Academy of Sciences
2016
Wojskowy Instytut Medycyny Lotniczej
2016
University of Manchester
2011
University of Nottingham
2011
Medical University of Warsaw
2010
The function of the sino-atrial node (SAN), pacemaker heart, is known to decline with age, resulting in disease elderly. aim study was investigate effects ageing on SAN by characterizing electrophysiological changes and determining whether gene expression are involved. In young old rats, characterized anaesthetized animal, isolated heart right atrium using ECG action potential recordings; quantitative PCR. declined age as follows: intrinsic rate 18 ± 3%; corrected recovery time increased 43...
β-Blockers reduce mortality and morbidity in heart failure. Many of their benefits can be explained solely by rate reduction (HRR). We aimed to verify whether the β-blocker, metoprolol, pure heart-rate-reducing agent, ivabradine, have same effects on haemodynamic function, ventricular remodeling, Ca2+ handling post-myocardial infarction (MI) failure rat. Metoprolol (250 mg/kg/day) or ivabradine (10 mg/kg/day), offering similar HRR, no treatment, was started 24 h after an induction MI sham...
Background— Heart failure (HF) causes a decline in the function of pacemaker heart—the sinoatrial node (SAN). The aim study was to investigate HF-induced changes expression ion channels and related proteins underlying activity SAN. Methods Results— HF induced rats by ligation proximal left coronary artery. animals showed an increase ventricular (LV) diastolic pressure (317%) decrease LV systolic (19%) compared with sham-operated animals. They also SAN dysfunction wherein intrinsic heart rate...
Ventricular arrhythmias are an important cause of mortality in the acute myocardial infarction (MI). To elucidate effect ivabradine, pure heart rate (HR) reducing drug, on ventricular within 24 h after non-reperfused MI rat. ECG was recorded for untreated and ivabradine treated rats episodes tachycardia/fibrillation (VT/VF) were identified. Forty-five minutes twenty-four hours epicardial monophasic action potentials (MAPs) recorded, cardiomyocyte Ca2+ handling assessed expression function...
Abstract Iron deficiency (ID) commonly occurs in chronic heart failure (HF) and is associated with poor prognosis. Neither its causes nor pathophysiological significance are clearly understood. We aimed to assess iron status the effect of supplementation rat model post-myocardial infarction (MI) HF. Four weeks after induction MI induce HF or sham surgery, rats received intravenous (ferric carboxymaltose) saline, 4 doses 1-week intervals. alone did not cause anemia, systemic myocardial ID,...
Plasmalemmal Ca(2+)-ATPase (PMCA) is involved in Ca(2+) handling and the regulation of intracellular signalling pathways heart. However, there no information on its functioning heart hypertrophy failure. We aimed to investigate Ca(2+)-transporting ability PMCA, Na(+)/Ca(2+) exchanger (NCX), sarcoplasmic reticulum (SR) (SERCA2a), as well amplitude transients cell shortening myocytes isolated from rat hearts at various time intervals after myocardial infarction (MI).The rate transport by NCX,...
Pulmonary hypertension (PH) initially results in compensatory right ventricular (RV) hypertrophy, but eventually RV failure. This transition is poorly understood, may be triggered by hypoxia. Measurements of oxygen tension (pO2) PH are lacking. We hypothesized that hypoxia occurs monocrotaline-induced rats and myo-inositol trispyrophosphate (ITPP), facilitating dissociation from hemoglobin, can relieve it. Rats received monocrotaline or saline (control) 24 days later echocardiograms,...
Immunoglobulin G-lacking galactose (Gal[0]) appears to be helpful in differential diagnosis of early synovitis, and correlates with disease activity rheumatoid arthritis (RA). Its utility for RA monitoring prognosis has been evaluated the present study. Forty-eight patients were observed 3 years. Hand radiographs assessed according Larsen results expressed as damage score (DS) progression (PDS). Gal[0], DS, PDS at onset study after 1 The average values Gal[0] observation significantly higher...
The impact of sex and age on the arrhythmic susceptibility within setting acute ischemia is masked by fact that coronary events result from artery disease appearing with much earlier among men than women.LAD ligation or sham operations were performed in rats both sexes at 3 24 months. An ECG was recorded continuously for 6 h after operation. number early late premature ventricular beats (PVBs), episodes tachycardia (VT) fibrillation (VF), heart rate, QRS, QT Tpeak-Tend duration analysed....
Abstract The incidence of life-threatening ventricular arrhythmias, the most common cause sudden cardiac death (SCD), depends largely on arrhythmic substrate that develops in myocardium during aging process. There is a large deficit comparative studies development this both sexes, with particular paucity females. To identify substrates arrhythmia, fibrosis, cardiomyocyte hypertrophy, mitochondrial density, oxidative stress, antioxidant defense and intracellular Ca 2+ signaling isolated...
Myocardial infarction (MI) often results in left ventricular (LV) remodeling followed by heart failure (HF). It is of great clinical importance to understand the molecular mechanisms that trigger transition from compensated LV injury HF and identify relevant diagnostic biomarkers. The aim this study was investigate gene expression evaluate their reflection peripheral blood mononuclear cells (PBMCs).MI induced rats ligation proximal coronary artery. Rats with small, moderate, large MI size...