A5027121122- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Respiratory Support and Mechanisms
- Burn Injury Management and Outcomes
- Sepsis Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Thermal Regulation in Medicine
- Traumatic Brain Injury and Neurovascular Disturbances
- Transplantation: Methods and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Anesthesia and Sedative Agents
- Neuroscience of respiration and sleep
- Hemodynamic Monitoring and Therapy
- Tracheal and airway disorders
- Acupuncture Treatment Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Atrial Fibrillation Management and Outcomes
- Anesthesia and Neurotoxicity Research
- Restraint-Related Deaths
- Antibiotics Pharmacokinetics and Efficacy
- Injury Epidemiology and Prevention
- Electrolyte and hormonal disorders
- Pain Management and Placebo Effect
University of Florida
2022-2025
Philipps University of Marburg
2016-2025
Prince Charles Hospital
2016-2025
The University of Queensland
2016-2025
INTEGRIS Baptist Medical Center
2019-2024
Manchester University NHS Foundation Trust
2018-2024
Manchester Academic Health Science Centre
2016-2024
Florida College
2022-2024
Manchester Royal Infirmary
2016-2024
Maastricht University
2024
Smoke inhalation injury continues to increase morbidity and mortality in burn patients both the third world industrialized countries. The lack of uniform criteria for diagnosis definition smoke contributes fact that, despite extensive research, rates have changed little recent decades. formation reactive oxygen nitrogen species, as well procoagulant antifibrinolytic imbalance alveolar homeostasis, all play a central role pathogenesis injury. Further hallmarks include massive airway...
Pulmonary injury from smoke inhalation is common in burn victims, significantly contributing to the morbidity and mortality of fire-related injuries. The impacts improvement other aspects care have not been mirrored treatment inhalation. Smoke heterogeneous unique each fire; it comprises particulates, respiratory irritants systemic toxins as well heat, all pathological insult. Thermal below vocal cords rare because effective heat dissipation upper airway. Particulate matter chief contributor...
To determine if the selective vasopressin type 1a receptor agonist selepressin (FE 202158) is as effective mixed receptor/vasopressin V2 vasopressor hormone arginine when used a titrated first-line therapy in an ovine model of Pseudomonas aeruginosa pneumonia-induced severe sepsis.Prospective, randomized, controlled laboratory experiment.University animal research facility.Forty-five chronically instrumented sheep.Sheep were anesthetized, insufflated with cooled cotton smoke via...
For single-lumen veno-pulmonary extracorporeal membrane oxygenation (VP ECMO) cannulation in percutaneous technique, vascular ultrasound (U/S) and transesophageal echocardiography (TEE) guidance were used to insert a 7 Fr pulmonary artery catheter (PAC) an Amplatz Super Stiff (Boston Scientific) 0.035 inch × 260 cm guide wire (through the PAC) into (PA). The PAC was removed, kept position. After dilation, long flexible 19 50 single-stage ECMO cannula inserted over stiff with its tip PA, 23...
Objective: The ProtekDuo with oxygenator mimics veno-venous (V-V) extracorporeal membrane oxygenation (ECMO) in veno-pulmonary (V-P) configuration. We have recently developed a new configuration by utilizing 25 Fr multistage femoral venous drainage cannula and returning oxygenated blood through both lumina of the double lumen (V-VP configuration), thereby creating partial right ventricular bypass flow up to seven LPM. investigated our experience V-P V-VP ECMO patients suffering from COVID-19...
We present a case of acute respiratory distress syndrome (ARDS) secondary to COVID-19 who required venovenous extracorporeal membrane oxygenation (V-V ECMO). Initially, right ventricular assist device (RVAD), the ProtekDuo with an oxygenator, was placed in outside heart center and patient transferred us for ECMO management. Due severe hypoxia, configuration later modified, 25 Fr femoral drainage cannula inserted venous only. The arterial return tubing spliced using Y-connector, arterialized...
Veno-arterial extracorporeal membrane oxygenation (VA ECMO) for the management of refractory cardiogenic shock (CS) has been widely used in recent years. Increased left ventricular (LV) afterload induced by retrograde flow remains a limiting factor, which is particularly evident during peripheral VA ECMO support. The concomitant use intra-aortic balloon pump (IABP) an established strategy to achieve LV unloading Nevertheless, there controversy about combined IABP central or terms beneficial...
Venovenous extracorporeal membrane oxygenation is the most commonly used mode of support in pre-lung transplant recipients. In patients who experience right ventricular dysfunction, venopulmonary ECMO an excellent option to preserve RV function. We retrospectively reviewed were supported with ECMO. Descriptive analysis, patient characteristics, outcomes, and survival assessed. The primary outcome was mortality. Mean age 45.5 ± 15.63, mean hours 1391.75 1239.01. 4 had dysfunction. All...
Excessive NO has been shown to play a major role in the pathogenesis of multiple organ dysfunctions septic condition. Burn injury, especially if it is associated with smoke inhalation, often complicated by subsequent development pneumonia or sepsis that determine outcome. In present study, we developed an ovine model, created exposing sheep inhalation followed instillation bacteria into airway, closely mimics human and pneumonia. We hypothesized inhibition iNOS-derived excessive might be...