A5061151413- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Membrane Separation and Gas Transport
- RNA modifications and cancer
- Membrane Separation Technologies
- Biosensors and Analytical Detection
- Paraquat toxicity studies and treatments
- RNA Interference and Gene Delivery
- Spectroscopy Techniques in Biomedical and Chemical Research
- Pulmonary Hypertension Research and Treatments
- Graphene and Nanomaterials Applications
- Drug Solubulity and Delivery Systems
- Advanced ceramic materials synthesis
- MicroRNA in disease regulation
- Advanced Drug Delivery Systems
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Acute Ischemic Stroke Management
- Nanocluster Synthesis and Applications
- Cancer-related molecular mechanisms research
- Electrospun Nanofibers in Biomedical Applications
- Membrane-based Ion Separation Techniques
- Angiogenesis and VEGF in Cancer
Wuhan Polytechnic University
2025
China Agricultural University
2025
Nanjing Medical University
2016-2024
Institute of Forensic Science
2022-2024
Fudan University Shanghai Cancer Center
2018-2024
Jiangsu Province Hospital
2020-2024
Henan University
2020-2024
Shanghai Medical College of Fudan University
2024
Jilin University
2024
Nanjing University of Chinese Medicine
2022-2024
Abstract Increasing cellular immunogenicity and reshaping the immune tumor microenvironment (TME) are crucial for antitumor immunotherapy. Herein, this work develops a novel single‐atom nanozyme pyroptosis initiator: UK5099 pyruvate oxidase (POx)‐co‐loaded Cu‐NS (Cu‐NS@UK@POx), that not only trigger through cascade biocatalysis to boost of cells, but also remodel immunosuppressive TME by targeting metabolism. By replacing N with weakly electronegative S, original spatial symmetry Cu‐N 4...
Biodegradable and pH‐responsive carboxymethyl cellulose/poly(acrylic acid) hybrid hydrogels are synthesized. The deswell in acidic artificial gastric fluid (AGF) but rapidly swell neutral intestinal (AIF), rendering selective enzymatic degradation of the gels as well accelerated drug release from insulin‐loaded AIF. Oral administration to streptozotocin‐induced diabetic rats leads a continuous decline fasting blood glucose level within 6 h post‐administration, relative pharmacological...
Nanoscale carriers that stably load drugs in blood circulation and release the payloads desirable sites response to a specific trigger are of great interest for smart drug delivery systems. For this purpose, novel type disulfide core cross‐linked micelles, which facilely fabricated by cross‐linking poly(ethylene glycol)/polyurethane block copolymers containing cyclic moieties via thiol‐disulfide exchange reaction, developed. A broad‐spectrum anti‐cancer drug, doxorubicin (DOX), is loaded...
A novel nanosensor was explored for the highly selective detection of intracellular carbon monoxide (CO) by surface enhanced Raman spectroscopy (SERS) on basis palladacycle carbonylation. By assembling new synthesized palladacycles (PC) gold nanoparticles (AuNPs), SERS nanosensors (AuNP/PC) were prepared with good activity and reactivity CO. When AuNP/PC incubated a CO-containing system, carbonylation PC assembled AuNPs initiated, corresponding spectra changed significantly, which allowed...
The combination of gene therapy and chemotherapy has recently received considerable attention for cancer treatment. However, low transfection efficiency poor endosomal escape genes from nanocarriers strongly limit the success clinical use small interfering RNA (siRNA). In this study, a novel pH-responsive, surface-modified single-walled carbon nanotube (SWCNT) was designed codelivery doxorubicin (DOX) survivin siRNA. Polyethylenimine (PEI) covalently conjugated with betaine, resulting...
Pulmonary hypertension (PH) is a devastating disease characterized by irreversible pulmonary vascular remodeling (PVR) that causes right ventricular failure and death. The early alternative activation of macrophages critical event in the development PVR PH, but underlying mechanisms remain elusive. Previously we have shown N6-methyladenosine (m6A) modifications RNA contribute to phenotypic switching artery smooth muscle cells PH. In current study, identify Ythdf2, an m6A reader, as important...
Appropriate separation and enrichment steps can enhance the performance of SERS assays. For rapid, in-situ detection carbaryl, a novel PA-6/AuNRs@ZIF-8 film that be applied to dual-mode detection, has been developed. In film, PA-6 was used as TLC substrate for initial substance measured. ZIF-8 provides chemical enhancement in well secondary analytes. Utilizing this we have successfully implemented TLC-SERS rapid scheme, resulting limit carbaryl low 1 × 10–9 M lake water 15 min, which is...
Intracellular pH-sensitive micelles of PEG-block-acetalated-dextran (PEG-b-AC-Dex) were prepared and used for acid-triggered intracellular release anticancer drug. The hydrodynamic radii (Rh) PEG-b-AC-Dex could increase after incubation in PBS solution at pH 5.5. Based on the pH-responsive Rh variation behavior, it was expected that should be interesting drug delivery. Thus, doxorubicin (DOX), a wide-spectrum drug, loaded into pH-dependent payload DOX tested vitro. vitro profiles showed only...
Biodegradable stereocomplex micelles (SCMs) based on amphiphilic dextran-block-polylactide (Dex-b-PLA) were designed and used for efficient intracellular drug deliveries. The Dex-b-PLA copolymers successfully synthesized by click reaction. structures of the resultant verified 1H NMR FT-IR spectra. formation stable through self-assembly driven stereocomplexation between enantiomeric l- d-PLA blocks was characterized transmission electron microscopy (TEM), dynamic laser scattering (DLS),...
pH-responsive supramolecular amphiphilic micelles based on benzimidazole-terminated poly(ethylene glycol) (PEG-BM) and β-cyclodextrin-modified poly(L-lactide) (CD-PLLA) were developed by exploiting the host-guest interaction between benzimidazole (BM) β-cyclodextrin (β-CD). The dissociation of was triggered in acidic environments. An antineoplastic drug, doxorubicin (DOX), loaded into as a model drug. release DOX from clearly accelerated pH reduced 7.4 to 5.5. DOX-loaded PEG-BM/CD-PLLA...
Ovarian cancer is the most malignant gynecologic among women worldwide. Cryptotanshinone (CT), isolated from Salvia miltiorrhiza Bunge, has been identified as a potential therapeutic agent in treating several tumors, but molecular mechanism of CT ovarian still remains illustrated. Here, we sought to elucidate regulatory function on cell glucose metabolism cancer. The treatment cells effectively inhibited uptake and lactate production cells. expression levels glycolysis-related proteins, such...
Abstract The Hippo–Yap pathway conveys oncogenic signals, but its regulation during cancer development is not well understood. Here, we identify the nuclear receptor RARγ as a regulator of in colorectal tumorigenesis and metastasis. downregulated human tissues, where expression correlates inversely with tumor size, TNM stage, distant Functional studies established that silencing drove cell growth, invasion, metastatic properties both vitro vivo. Mechanistically, controlled signaling to...
This study aimed to improve the dissolution rate and oral bioavailability of valsartan (VAL), a poorly soluble drug using solid dispersions (SDs). The SDs were prepared by freeze-drying technique with polyethylene glycol 6000 (PEG6000) hydroxypropylmethylcellulose (HPMC 100KV) as hydrophilic polymers, sodium hydroxide (NaOH) an alkalizer, poloxamer 188 surfactant without any organic solvents. In vitro physicochemical properties characterized USP paddle method, differential scanning...
Abnormal expression of microRNAs (miRNAs) is often associated with tumorigenesis, metastasis, and progression. Among them, miRNA-21 found to be overexpressed in most the cancer cells. Here, a binary system designed for targeted imaging photothermal treatment single The composed by pair probes (probe-1 probe-2), which are encapsulated liposomes cell delivery. Both two adopt gold nanoparticles (AuNPs) as core material, AuNPs functionalized Cy5-marked molecular beacon (MB-1/MB-2...
Solid lipid nanoparticles (SLNs) are one of the most promising nanocarriers to increase oral absorption drugs with poor solubility and low permeability. However, mechanism SLNs remains incomplete thus requires further careful consideration. In this study, positively charged chitosan (CS) modified or hydroxypropyl trimethylammonium chloride (HACC) were designed their mechanisms fully clarified improve docetaxel (DTX). The HACC-DTX-SLNs showed highest cellular uptake in Caco-2 cell monolayer;...
Abstract The monitoring of cancer biomarkers is crucial to the early detection cancer. However, a limiting factor in biomarker analysis ability obtain multilayered information various molecules located at different parts cells from plasma membrane cytoplasm. A two‐stage dissociation nanoparticle system based on multifunctionalized polydopamine‐coated gold nanoparticles (Au@PDA NPs) reported, which allows for imaging single cells. We demonstrate feasibility this strategy sialic acids (SAs),...
In EVs derived from plasma of acute coronary syndrome patients experiencing SCD, miR-208b-3p and miR-143-3p were significantly upregulated ultimately identified as reliable biomarkers for the prediction SCD.