A5101798386- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Advanced Topics in Algebra
- Immune cells in cancer
- Advanced Glycation End Products research
- Microtubule and mitosis dynamics
- Image and Video Quality Assessment
- Algebraic structures and combinatorial models
- Epigenetics and DNA Methylation
- Estrogen and related hormone effects
- Pancreatic and Hepatic Oncology Research
- Advanced Data Compression Techniques
- Cancer Mechanisms and Therapy
- Polynomial and algebraic computation
- Video Coding and Compression Technologies
- Neuroendocrine Tumor Research Advances
- Medicinal Plant Pharmacodynamics Research
- DNA Repair Mechanisms
- Cancer Cells and Metastasis
- Topological Materials and Phenomena
- Autophagy in Disease and Therapy
- Advanced Differential Geometry Research
- Energy Load and Power Forecasting
Fudan University
2015-2024
Shanghai First People's Hospital
2021-2024
Shanghai Jiao Tong University
2022-2024
China Electric Power Research Institute
2023-2024
Cornell University
2024
North China Electric Power University
2023-2024
Wuhan University
2024
University of Bristol
2023-2024
Zhongnan Hospital of Wuhan University
2024
East China Normal University
2024
The interplay between p53 and RAS signaling regulates cancer chemoresistance, but the detailed mechanism is unclear. In this study, we investigated interactive effects of on ovarian cisplatin resistance to explore potential therapeutic targets. Methods: An inducible mutants active in either MAPK/ERK (S35 E38) or PI3K/AKT (C40) both (V12) were sequentially introduced into a p53-null cell line-SKOV3. Comparative microarray analysis was performed using Gene Chip Prime View Human Expression...
Retinoic acid-related orphan receptor C (RORC) is a member of the nuclear family and performs critical regulatory functions in cell proliferation, metastasis, chemoresistance various types malignant tumors. Here we showed that expression RORC lost tumor tissues bladder cancer patients. Enhanced suppressed proliferation glucose metabolism increased cisplatin-induced apoptosis vitro vivo. bound promoter region programmed death ligand-1 (PD-L1) negatively regulated PD-L1 expression. directly...
Cancer-associated fibroblasts (CAFs) are a vital constituent of the tumor microenvironment (TME) and have several activities, but effect CAF heterogeneity on molecular features clinical outcomes pancreatic ductal adenocarcinoma (PDAC) remains unknown.An algorithm "scFrac" based single-cell sequencing data from Gene Expression Omnibus was introduced to emulate enrichment subtypes in TCGA-PDAC cohort their prognostic influence, confirmed by an external validation group (66 patients with PDAC)...
Ovarian cancer is the most malignant gynecologic among women worldwide. Cryptotanshinone (CT), isolated from Salvia miltiorrhiza Bunge, has been identified as a potential therapeutic agent in treating several tumors, but molecular mechanism of CT ovarian still remains illustrated. Here, we sought to elucidate regulatory function on cell glucose metabolism cancer. The treatment cells effectively inhibited uptake and lactate production cells. expression levels glycolysis-related proteins, such...
// Ziliang Wang 1, 3, * , Yang Liu 2, Lili Lu 4 Lina 3 Sheng Yin Yan Zihao Qi Jiao Meng Rongyu Zang Gong 5 1 Cancer Institute, Fudan University Shanghai Center, 200032, China 2 Department of Gynecological Oncology, Medical College, University, Biology, Life and Environment Science Normal 200023, Central Laboratory, the Fifth People's Hospital 200240, These authors have contributed equally to this work Correspondence to: Zang, e-mail: ryzang@yahoo.com Yang, yanggong@fudan.edu.cn Keywords:...
Abstract Background Although programmed cell death‐ligand 1 (PD‐L1) plays a well‐known function in immune checkpoint response by interacting with death‐1 (PD‐1), the cell‐intrinsic role of PD‐L1 tumors is still unclear. Here, we explored molecular regulatory mechanism progression and metastasis ovarian cancer. Methods Immunohistochemistry benign tissues cancer samples was performed, followed migration, invasion, angiogenesis assays PD‐L1‐knockdown cells. Immunoprecipitation, mass...
Fructose-1,6-bisphosphatase (FBP1) is a rate-limiting enzyme in gluconeogenesis and an important tumor suppressor human malignancies. Here, we aimed to investigate the expression profile of FBP1 ovarian cancer, molecular mechanisms that regulate examine how regulatory axis contributes tumorigenesis progression cancer. We showed was significantly decreased cancer tissues compared with normal tissues, low-FBP1 predicted poor prognosis patients The enhanced cell lines suppressed proliferation...
Small ribosomal protein subunit S7 (RPS7) has been reported to be associated with various malignancies, but the role of RPS7 in ovarian cancer remains unclear. In this study, we found that silencing by a specific shRNA promoted cell proliferation, accelerated cycle progression, and slightly reduced apoptosis response cisplatin treatment. Knockdown resulted increased expression P85α, P110α, AKT2. Although basal levels ERK1/2, MEK1/2, P38 were inconsistently altered cells, phosphorylated forms...
Apatinib is a tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor-2 (VEGFR2), and has shown encouraging therapeutic effects in various malignant tumors. As yet, however, the role of apatinib ovarian cancer remained unknown. Here, we sought to elucidate vitro vivo viability proliferation cells, as well glucose metabolism these cells. The on cell were assessed using Cell Counting Kit-8 (CCK-8) colony formation assays, respectively. expression...
Ovarian cancer remains the leading cause of death in gynecologic malignancies partially because resistance to chemotherapy. In present study, we show that RY-2f, a chemically synthesized isoflavone analog, inhibited ovarian cell proliferation, blocked cycle G2/M phase and induced cellular apoptosis through up-regulation p21, cyclin B1, Bax, Bad cleaved-PARP, suppression A, CDK2 Bcl-2. We also RY-2f could increase chemotherapeutic efficacy cisplatin as tested by proliferation colony formation...
Apalutamide, a novel endocrine therapy agent, has been shown to significantly improve the prognosis of patients with metastatic hormone-sensitive prostate cancer (mHSPC). However, resistance apalutamide also reported, and underlying mechanism for this response yet be clearly elucidated. First, study established apalutamide-resistant (PCa) cells, confirmed that activated release calcium ions (Ca
It is well known that the activation of Aurora A/B (Aur A/B) or inactivation BRCA1/2 induces tumor formation. Others and we have reported mutual suppression between Aur may manipulate cancer cell growth tumorigenesis, however, interactive regulation mechanism these molecules are still elusive. In this study, by consecutive silencing or/and with specific shRNAs, showed that, in BRCA2-deficient pancreatic line Capan-1 ovarian OVCA433, inversely regulated expression each other likely through...
Inactivation of p53 greatly contributes to serous ovarian cancer, while the role wild-type induced phosphatase 1 (Wip1) is quite unclear. In this study, by silencing or overexpression Wip1, we found that Wip1 suppressed cancer cell invasion, migration, epithelial mesenchymal transition (EMT), and metastasis in xenograft animal models. Mechanistic studies showed may block through inhibition Snail p-Akt expression because either upregulated downregulated (Ser 473), further knockdown shRNA a...
Conventional linear precoding schemes in massive multiple-input-multiple-output (MIMO) systems, such as regularized zero-forcing (RZF) precoding, have near-optimal performance but suffer from high computational complexity due to the required matrix inversion of large size. To solve this problem, we propose a successive overrelaxation (SOR)-based scheme approximate by exploiting asymptotically orthogonal channel property MIMO systems. The proposed SOR- based can reduce about one order...
When subjected to quasiperiodic driving protocols, superconducting systems have been found harbor robust time-quasiperiodic Majorana modes, extending the concept beyond static and Floquet systems.However, presence of incommensurate frequencies results in dense energy spectra, rendering conventional methods defining topological invariants based on band structure inadequate.In this work, we introduce a real-space invariant capable identifying timequasiperiodic Majoranas by leveraging system's...
In the present study, we investigated in vitro antitumor functions of a synthetic chalcone derivative 4,3′,4′,5′- tetramethoxychalcone (TMOC) ovarian cancer cells. We found that TMOC inhibited proliferation and colony formation cisplatin sensitive cell line A2780 resistant A2780/CDDP, as well SKOV3 time- dose-dependent manner. Treatment cells with resulted G0/G1 cycle arrest through down-regulation cyclin D1 CDK4, up-regulation p16, p21 p27 proteins. demonstrated might induce apoptosis...
Barasertib is a highly selective Aurora kinase B (AURKB) inhibitor and has been widely applied in variety of cancer cells to investigate the regulatory function AURKB. However, effect barasertib on glucose metabolism gastric (GC) remains illustrated. Here, was identified effectively reduce uptake lactate production GC dose-dependent time-dependent manner. The expression levels GLUT1, LDHA HK2 were decreased by treatment cells. Furthermore, we found that induced ribosomal protein S7 (RPS7),...
The paradigm of Floquet engineering topological states matter can be generalized into the time-quasiperiodic scenario, where a lower-dimensional time-dependent system maps onto higher-dimensional one by combining physical dimensions with additional synthetic generated multiple incommensurate driving frequencies. Differently from most previous works in which gapped phases were considered, we propose an experimentally realizable, one-dimensional chain driven two frequencies, gapless Weyl...