A5100394617- Microtubule and mitosis dynamics
- Geological and Geochemical Analysis
- Ubiquitin and proteasome pathways
- Biochemical and Molecular Research
- Geophysical and Geoelectrical Methods
- Protein Structure and Dynamics
- Sirtuins and Resveratrol in Medicine
- Advanced Battery Materials and Technologies
- earthquake and tectonic studies
- High-pressure geophysics and materials
- Advancements in Battery Materials
- Magnetic Field Sensors Techniques
- Calcium signaling and nucleotide metabolism
- Fire effects on ecosystems
- Landslides and related hazards
- ATP Synthase and ATPases Research
- Diatoms and Algae Research
- Cancer Mechanisms and Therapy
- Medical Imaging and Analysis
- Ionosphere and magnetosphere dynamics
- Fluid Dynamics and Vibration Analysis
- Cancer therapeutics and mechanisms
- Aerodynamics and Fluid Dynamics Research
- Computational Drug Discovery Methods
- Biochemical effects in animals
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2025
Wangjing Hospital of China Academy of Chinese Medical Sciences
2025
Jilin University
2010-2023
Nankai University
2019-2022
State Key Laboratory of Medicinal Chemical Biology
2019-2022
State Key Laboratory of Automotive Simulation and Control
2022
Chinese Academy of Sciences
2012-2021
Institute of Botany
2021
The People's Hospital of Guangxi Zhuang Autonomous Region
2021
Changchun Institute of Applied Chemistry
2012-2018
Mesoporous interconnected carbon-encapsulated Fe3O4 (Fe3O4@C) nanospheres assembled from tiny nanoparticle subunits have been synthesized by a one-pot solvothermal decomposition route followed thermal annealing. Electrochemical characterization of these Fe3O4@C exhibits capacity 636 mA h g−1 at 0.2–1 C over 50 cycles when employed as anode materials in Li-ion batteries.
Protein-DNA recognition is a central biological process that governs the life of cells. A protein will often undergo conformational transition to form functional complex with its target DNA. The dynamics are expected contribute stability and specificity DNA therefore may control activity protein-DNA complex. Understanding how influences still challenging. Here, we developed two-basin structure-based model explore in Sulfolobus solfataricus Y-family polymerase IV (DPO4) during binding With...
Responsive photonic crystals (PCs) with bio-inspired microstructures and tailorable functionalities are of critical importance for their potential applications in diverse fields such as biological detection, sensing, decoration, anti-counterfeiting, etc. However, limited by preparation technologies design theories, it is still a challenge to accurately uniformly deposit smart responsive materials on natural PC structures achieve dual stimulus response. Herein, simple rapid situ...
AbstractWidespread granitic intrusions in the northeast part of Wulonggou area were previously thought to be emplaced into Palaeoproterozoic Jinshuikou Group during Neoproterozoic. This contribution presents detailed LA-ICP-MS zircon U–Pb geochronology, major and trace element geochemistry, Hf isotope systematic on Granodiorite Xiaoyakou Granite from area. Three granodiorite samples yielded ages 247 ± 2, 248 1, 249 1 Ma, one granite sample age 246 3 Ma. The are metaluminous with an alumina...
Calmodulin (CaM) is found to have the capability bind multiple targets. Investigations on association mechanism of CaM its targets are crucial for understanding protein-protein binding and recognition. Here, we developed a structure-based model explore process between skMLCK peptide. We cooperation nonnative electrostatic interaction hydrophobic plays an important role in nonspecific recognition target. also that conserved anchors patches transition from high affinity specificity....
To explore the accuracy of human-computer interaction software in identifying and locating type C1 distal radius fractures. Based on relevant inclusion exclusion criteria, 14 cases fractures between September 2023 March 2024 were retrospectively analyzed, comprising 3 males 11 females(aged from 27 to 82 years). The data assigned randomized identifiers. A senior orthopedic physician reviewed films measured ulnar deviation angle, radial height, palmar inclination intra-articular step, gap for...
Debris flow susceptibility analysis is a prerequisite of risk assessment. The main objective this study was to explore the accuracy and practicability mapping units for evaluation debris susceptibility. These include grid cell (GCUs), watershed (WUs) with thresholds 10 000 (WU 000) 5000 5000). frequency ratio (FR) model selected as statistical method. Yongji County (YJC) Jilin Province, China research site, total 123 disasters were surveyed. Eight influencing factors considered three models...
Lithium-ion batteries are supposed to be a key method make more efficient use of energy. In the past decade, nanostructured electrode materials have been extensively studied and presented opportunity achieve superior performance for next-generation which require higher energy power densities longer cycle life. this article, we reviewed recent research activities on selective crystallization inorganic into electrodes lithium-ion discuss how can improve materials; example, exposure surfaces...
Microtubules play extensive roles in cellular processes, including cell motility. Stathmin is an important protein which destabilizes microtubules. The essential function of stathmin closely associated with its phosphorylation status. overexpressed many human cancers and has a significant relationship clinical characteristics such as grade, tumor size prognosis. We demonstrated that was ESCC tissues using both 2-DE immunohistochemistry analysis. In addition, overexpression significantly...
Abstract A simple procedure is reported for the fabrication of TiO 2 nanofibers via electrospinning technique using polylactic acid (PLA), tetrabutyl titanate, and hexafluoroisopropanol as a spinning solution. (600–700 nm in diameter), with bundled nanofibrils align fiber direction, are obtained from calcination as‐spun /PLA composite at 550°C. The structure physicochemical property generated elucidated by Fourier transform‐Infrared radiation spectrometer, X‐ray diffraction, scanning...
An air-coil sensor (ACS) is a type of induction magnetometer used as transducer to measure the variations magnetic field. This device widely applied in helicopter transient electromagnetic method (TEM) exploration. Most TEM explorations generate common-mode noise and require extreme ACS specifications, both which inevitably challenge geophysical explorations. study proposes differential air-core coil combined with pre-amplifier reduce induced exploration surveys. To satisfy stringent...
The air-core coil sensor (ACS) is widely used as a transducer to measure the variation in magnetic fields of helicopter transient electromagnetic (TEM) system. A high periodic emitting current induces field signal underground medium. However, such also generates primary that can affect received ACS and even damage receiver. To increase dynamic range protect receiver when rises/falls, combination with flux compensation structure (bucking coil) necessary. Moreover, optimized ACS, which...
Barasertib is a highly selective Aurora kinase B (AURKB) inhibitor and has been widely applied in variety of cancer cells to investigate the regulatory function AURKB. However, effect barasertib on glucose metabolism gastric (GC) remains illustrated. Here, was identified effectively reduce uptake lactate production GC dose-dependent time-dependent manner. The expression levels GLUT1, LDHA HK2 were decreased by treatment cells. Furthermore, we found that induced ribosomal protein S7 (RPS7),...
The Wulonggou area in the Eastern Kunlun Orogen (EKO) Northwest China is characterized by extensive granitic magmatism, ductile faulting, and orogenic gold mineralizations. Shidonggou granite located central part of area. This study investigated major as well trace-element compositions, zircon U–Pb dates, Hf isotopic compositions granite. Three samples yielded an average age 416 Ma (Late Silurian). Late Silurian peraluminous, with high alkali contents, Ga/Al ratios, (K2O + Na2O)/CaO...
Debris flow is one of the most frequently occurring geological disasters in Jilin province, China, and such often result loss human life property. The objective this study to propose verify an information fusion (IF) method order improve factors controlling debris as well accuracy susceptibility map. Nine layers (i.e., topography, elevation, annual precipitation, distance water system, slope angle, aspect, population density, lithology vegetation coverage) were taken predictors. improved by...
The microtubule-dependent motor protein Eg5 is essential for the development and function of mitotic spindle. Now it has become an anti-mitotic drug target in high throughput screening anticancer dugs vitro. Here a protocol cloning, expression purification human that codes linker domain Escherichia coli BL21 (DE3) cells. effects temperature, pH, metal ions DMSO on ATPase activity were investigated. A new compound CPUYL064 showed good inhibitory effect against (IC50 value, 100 nM). It...
During the process of ATP binding to an apo-kinesin microtubule (MT), kinesin core rotates on MT, and neck linker (NL) undergoes undocked docked transition. This has been suggested be a power stroke kinesin, basis structural analysis. Here, we developed mesoscopic structure-based model studied KIF1A. We quantified underlying free energy landscape showed emergence several states for KIF1A: UB-UR-UD (unbound, unrotating, undock), B-IR-UD (bound, initial rotating, B-PR-UD partial B-R-D dock)....
Sirtuins are a family of highly conserved NAD-dependent deacetylase that involved in multiple biological processes both prokaryotes and eukaryotes. Many sirtuin-activating compounds (STACs) have been reported for SIRT1, which is the best-characterized sirtuin. However, molecular mechanism SIRT1 activation by STACs remains controversial. Here, we developed multiscale simulation model to explore this mechanism. By quantifying free energy landscape closed conformation SIRT1-FdL...
In this study, a series of tetrahydroisoquinolines have been synthesized and identified as novel kinesine spindle protein (KSP) inhibitors based on the pharmacophore we mapped crystal structure monastrol bound to target protein. The KSP inhibitory activities all designed compounds were tested using cloned Human All thirteen more potent than control, monastrol, in adenosine triphosphatase (ATPase) assays. Three (1b, 1g, 1h) exhibited over 100 times higher potency monastrol. Cytotoxic results...
The Shenshuitan gold deposit is located within the Eastern Kunlun Orogen in northwest China. mineralization here occurs primarily ductile fault XI. sulfide mineral assemblage dominated by pyrite and arsenopyrite, with minor pyrrhotite, chalcopyrite, galena, sphalerite. Host rocks predominantly consist of Ordovician silicic slate late Silurian granites, their alterations include silicification sericitization. measured δD δ18O values quartz sericite range from −113.9‰ to −93.1‰ 4.6‰ 12.0‰,...