A5100449545- Gout, Hyperuricemia, Uric Acid
- Salivary Gland Disorders and Functions
- Pharmacological Effects of Natural Compounds
- Inflammasome and immune disorders
- Galectins and Cancer Biology
- Microbial infections and disease research
- interferon and immune responses
- Rheumatoid Arthritis Research and Therapies
- Cytokine Signaling Pathways and Interactions
- Parasitic Infections and Diagnostics
- Pneumonia and Respiratory Infections
- Case Reports on Hematomas
- Olfactory and Sensory Function Studies
- Urinary Tract Infections Management
- Phytochemicals and Antioxidant Activities
- Bacterial Infections and Vaccines
- HER2/EGFR in Cancer Research
- Escherichia coli research studies
- Tuberculosis Research and Epidemiology
- Medicinal Plant Pharmacodynamics Research
- Spondyloarthritis Studies and Treatments
- Medicinal plant effects and applications
- Phytochemistry and Biological Activities
- Flavonoids in Medical Research
- Pancreatic and Hepatic Oncology Research
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2020-2025
Tianjin University of Traditional Chinese Medicine
2022
Lanzhou University
2016
Lanzhou University Second Hospital
2016
Second Military Medical University
2009
Acute Gouty Arthritis (AGA) is characterized by a rapid inflammatory reaction caused the build-up of monosodium urate (MSU) crystals in tissues surrounding joints. This condition often associated with hyperuricemia, distinguished its symptoms intense pain, active inflammation, and swelling Traditional approaches AGA management fall short desired outcomes clinical settings. However, recent ethnopharmacological investigations have been focusing on potential Herbal Medicine (THM) various forms,...
Background . Huangqi Guizhi Wuwu Decoction (HGWD) has been applied in the treatment of joint pain for more than 1000 years China. Currently, most physicians use HGWD to treat rheumatoid arthritis (RA), and it proved have high efficacy. Therefore, is necessary explore potential mechanism action RA based on network pharmacology molecular docking methods. Methods The active compounds were collected, their targets identified from Traditional Chinese Medicine Systems Pharmacology Database (TCMSP)...
Purpose: Baicalin is a flavonoid of Scutellaria baicalensis Georgi. It possesses antipyretic, analgesic, and anti-inflammatory effects. has great potential to treat gout. A network pharmacology approach, molecular docking experimental validation were applied investigate the pharmacological mechanisms baicalin in treating Methods: The targets retrieved from TCMSP, PharmMapper, STITCH, Swiss Target Prediction databases. gout-related DrugBank, TTD, Genecards Then, signaling pathways acquired...
Traditional Chinese medicine (TCM) has certain curative effect against acute gouty arthritis (AGA), but it lacks high-quality evidence-based studies. In this randomized controlled trial, we try to evaluate the clinical efficacy and safety of Qinpi Tongfeng Formula (QPTFF) in treatment AGA.One hundred fourteen patients with AGA (damp heat accumulation syndrome) who met inclusion exclusion criteria were randomly divided into group control a ratio 1 : 1. Patients treated QPTFF, diclofenac...
Acute gouty arthritis (AGA) is characterized by the accumulation of monosodium urate crystals within joints, leading to inflammation and severe pain. Western medicine treatments have limitations in addressing this condition. Previous studies shown efficacy Qinpi Tongfeng formula (QPTFF) treating AGA, but further investigation needed understand its mechanism action.
Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease characterized by lymphocyte infiltration of the exocrine glands. The typical clinical symptoms pSS include dryness mouth (xerostomia) and eyes (xerophthalmia), fatigue, joint pain. Cuproptosis recently identified mode programmed cell death that leads to progression multiple diseases, precise etiology pathophysiology remain unknown. Consequently, aim our study was explore cuproptosis-related molecular clusters identify...
Sjögren's syndrome (SS) is an autoimmune disease, and its conventional treatment has exhibited limited therapeutic efficacy. Qing Zao Fang (QZF), a traditional Chinese medicine formula, used in the of syndrome, but chemical composition complex, pharmacological mechanism not clear. Therefore, this study aims to explore potential QZF based on network pharmacology SS mouse model. The main active components predicted targets were analyzed by pharmacology. model was constructed divided into 6...
Sjögren's syndrome (SS) which could lead to a disorder of our immune system is chronic autoimmune disease characterized by invading exocrine glands such as salivary and lacrimal other glands. Its common symptom dry mouth eyes, often accompanied large number lymphocyte infiltrations can involve organs cause complex clinical manifestations. In this study, we aimed at investigating the effect QZF in SS, identifying molecular mechanism modulating response, determining important roles these...
Postoperative urinary retention (POUR) is one of the most common complications after hemorrhoidectomy. The best treatment for POUR prevention and should be involved in whole perioperative period. Moxibustion has been used to treat thousands years, clinical studies have also proved its effects. We try carry out a randomized, controlled, prospective study observe whether prophylactic moxibustion could effectively reduce incidence hemorrhoidectomy 24 h.This single-center, evaluator-blinded,...
Haemophilus influenzae (Hi) is an important human pathogen that causes severe infections including meningitis, bacteremic pneumonia and sepsis, mostly affecting young children. The resistance of Hi to antimicro-bials has risen wide variations exist in antibiotic resistance, both geographically over time. main mechanisms are those β-lactam antibiotics. Antibiotic utilization the risk factors for deve-lopment antimicrobial resistance. Third-generation cephalosporins most effective agent treat...
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by progressive articular damage, functional loss and comorbidity. Cuproptosis recently reported form of programmed cell death, which still remains void in RA. Consequently, this study aimed to explore cuproptosis-related molecular clusters RA.Methods: Gene expression profiles GSE93272 were downloaded from the Expression Omnibus identify cuproptosis regulators immune infiltration characteristics Subsequently,...
To found the clinical role of T cell immunoglobulin and mucin domain-containing protein 3 programmed death 1 expression from peripheral blood in patients with colon cancer is objective study. Total 98 our hospital between January 2020 March 2022 were considered as study group. An additional 86 healthy subjects Spearman correlation analysis was used to detect features receiver operating characteristic curve diagnosis values indexes. The 3+, 1+ 3+ significantly higher group than that (p<0.05)....
Objective To investigate the expression of sialic acid-binding immunoglobulin-like lectin-one (Siglec-1, also called CD169) in lymphocytes, monocytes and neutrophils peripheral blood patients with coronary heart disease(CHD), explore relationship between Siglec-1 atheresclerosis. Methods CD145 CD169 positive cell proportion mRNA levels were respectively measured by flow cytometry real-time quantitative reverse transcription-polymerase chain reaction (FQ-RT-PCR) 57 CHD 38 healthy controls....