Abstract The exact mechanism of myocardial hypertrophy has not been completely elucidated. NOD-like receptor protein 3 (NLRP3) and the pyroptotic cascade play a critical role in cardiac inflammation. myokine irisin can inhibit NLRP3 activation, although its action is unknown. In this study, we induced mouse model via aortic constriction (TAC) to further explore pathological inflammasome-mediated pyroptosis potential therapeutic effects irisin. Cardiac significantly increased percentage...

Endocrine-disrupting chemicals (EDCs) have been reported to affect populations by disrupting the human endocrine system. Di-(2-ethylhexyl) phthalate (DEHP) is an EDC that present in various consumer products. Exposure DEHP could contribute reproductive system dysfunction, with subsequent adverse female outcomes. Granulosa cells (GCs) play essential roles ovarian function and fertility. To further reveal underlying mechanism which impairs fertility affects normal of GCs, vivo vitro...

Retinal diseases encompass various conditions associated with sight-threatening immune responses and are leading causes of blindness worldwide. These include age-related macular degeneration, diabetic retinopathy, glaucoma uveitis. Emerging evidence underscores the vital role innate response in retinal diseases, beyond previously emphasized T-cell-driven processes adaptive system. In particular, pyroptosis, a newly discovered programmed cell death process involving inflammasome formation,...

The newly highlighted research into programmed cell death (PCD), autophagy dependent and pyroptotic death, has shown that these processes are both strongly correlated with the pathological progression of traumatic brain injury (TBI). However, their cross-talk in TBI remains unclear. Here, a moderate model was established to explore relationship between pyroptosis. Rapamycin used activate process autophagy, which impaired model, this treatment reversed expression pyroptosis associated...

Objective. Deficiencies in klotho are implicated various kidney dysfunctions including diabetic nephropathy (DN) related to inflammatory responses. Klotho is closely responses and a potential target for ameliorating failure. Pyroptosis, an form of programmed cell death, reported take part DN pathogenesis recently. This study aimed at exploring whether how inhibited podocyte pyroptosis astragaloside IV (AS-IV) protect through the regulation klotho. Materials Methods. SD rat model...

Inflammatory bowel disease (IBD) is a chronic relapsing gastrointestinal disorder, while the treatment effect not satisfactory. Immune responsive gene 1 (IRG1) highly expressed in macrophage response to inflammatory and catalyzes production of itaconate. Studies have reported that IRG1/itaconate has significant antioxidant effect. This study aimed investigate mechanism on dextran sulfate sodium (DSS)-induced colitis vivo vitro. In experiments, we found exerted protective effects against...

Sinomenine (SIN), a bioactive isoquinoline alkaloid extracted from the roots and stems of Sinomenium acutum, is efficacious against various chronic pain conditions. Inhibition microglial activation at spinal level contributes to analgesic effects SIN. Microglial in dorsal horn key sensitising neuropathic pain. Consequently, this study aimed investigate whether antinociceptive SIN are induced through inhibition underlying mechanisms. In study, we observed that alleviated constriction injury...

Diabetic nephropathy (DN), a complication of diabetes, is the result high glucose-induced pathological changes in podocytes, such as epithelial-mesenchymal transition (EMT). Autophagy an important mechanism podocyte repair. Ginsenoside Rg1, active ingredient ginseng extract, has antifibrotic and proautophagic effects. Therefore, we hypothesized that ginsenoside Rg1 can reverse EMT via autophagy alleviate DN.This study aimed to investigate effect on DN rats by regulating AKT/GSK3β/β/.Diabetic...

Pulmonary hypertension (PH) is characterized by progressive pulmonary arterial remodelling, associated with different severities of inflammation and altered immune processes. Disulfiram eliminates the formation N-gasdermin D (GSDMD) plasma membrane pores to prevent pyroptosis. Pyroptosis a form lytic cell death inflammasome activation proinflammatory cytokine release that acts in development PH. We sought investigate whether disulfiram could alleviate hypoxia-induced PH inhibiting

Podocyte injury plays an important role in diabetic nephropathy (DN). The aim of this study was to determine the potential therapeutic effects ginsenoside Rg1 on hyperlipidemia-stressed podocytes and elucidate underlying mechanisms.In vitro vivo models DN were established as previously described, expression levels relevant markers analyzed by Western blotting, real-time Polymerase Chain Reaction (PCR), immunofluorescence, immunohistochemistry.Ginsenoside alleviated pyroptosis cultured under...

Chronic obstructive pulmonary disease (COPD) is a common inflammatory airway characterized by enhanced inflammation. Recent studies suggest that mitochondrial damage-associated molecular patterns (DAMPs) may play an important role in the regulation of inflammation and are involved serial diseases, they also be COPD. This review highlights potential DAMPs during COPD pathogenesis discusses therapeutic targeting their related signaling pathways receptors for Research progress on enhance our...

Diabetic nephropathy (DN) is a progressive microvascular complication of diabetes mellitus (DM), driven largely by podocyte apoptosis. The cysteine protease Calpain 10 known to augment apoptosis and necrosis, potential therapeutic target in DN.Type 2 was induced SD rats high-fat diet (HFD) feeding streptozotocin (STZ) injections, simulated vitro culturing conditionally immortalized mouse podocytes hyperlipidemic (PA, 100 μM) conditions. rate the renal tissues cultured determined TUNEL assay....

The seeds of Aesculus wilsonii were reported to be rich in saponins and have anti-inflammatory activity. However, the phytochemistry investigation its is not clear yet, bioactivity also rare. Therefore, detailed constituents' study on from A. was performed, eleven new isolates, aeswilsaponins IA–IH (1–8), ⅡA (9), ⅡB (10) ⅢC (11), along with twenty analogs (12–31) yielded. All them examined for their inhibitory effects NO release LPS-induced RAW264.7 cells, indicating that 1, 4, 5, 12, 18,...

Pulmonary endometriosis (PEM) is rare, and drug therapy remains the primary treatment. However, patients with PEM frequently experience recurrent hemoptysis that refractory to pharmacological intervention. We herein describe a patient who developed was successfully treated photodynamic (PDT) after withdrawal. The admitted our hospital because of despite repeated treatments for more than 1 year. Given PDT targets specific tissues destroys vascular endothelial cells through cytotoxic effect...

The early events that lead to the inflammatory and immune-modulatory effects of radiation therapy (RT) in tumor microenvironment (TME) after its DNA damage response activating innate DNA-sensing pathways are largely unknown. Neutrophilic infiltration into TME RT is an occurs within 24–48 h. Using two different syngeneic murine models (RM-9 MC-38), we demonstrated CXCR2 blockade significantly reduced RT-induced neutrophilic infiltration. showed same on inhibition host survival as direct...

Objective: To investigate the relation of activation site and number with clinical response to bronchial thermoplasty (BT) in refractory asthma patients. Methods: This work included 106 consecutive patients completing three BT sessions our hospital from May 2016 2019. Procedure details recording delivery sites those BT. Asthma Control Questionnaire (ACQ) scores spirometric measurements were recorded 1-day before treatment 6 months post-treatment explore effects on response. Results: ACQ...